Protein Alignment Snoo and skil

DIOPT Version :10

• Sequence 1: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: XP_002931592.1
• Gene: skil / 100492636
• XenbaseID: XB-GENE-486095
• Length: 643
• Species: Xenopus tropicalis
• Alignment Length: 645
• Identity: 181/645 - (28%)
• Similarity: 262/645 - (40%)
• Gaps: 181/645 - (28%)

  Fly     5 VTPMISTVLKKYQTSATKSLQGPGHALTTAGVLDIVTNGRSESPGLNGKCQASPPVVALIKKEIL 69
            :.|.:...|.::..|:..||.||.           ..:.|.....:      ||.|       .|
 Frog    64 LNPGLKHTLAQFNLSSRSSLGGPA-----------AFSARFSHENM------SPTV-------FL 104

  Fly    70 SSPEPQDLHHHECSTRGTPPQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGE 134
            ..|.|| :|         |..::.|:....||:|               |:|||::|.||.||||
 Frog   105 PLPSPQ-IH---------PGPLFIPSDSSTELTQ---------------TELEGESISCFMVGGE 144

  Fly   135 MRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAE 199
            .||||||.||:||.||||:|||.:.||:.||||:||.|||...|...|||.:..:.||||.|||:
 Frog   145 KRLCLPQVLNSVLRDFSLQQINIVCDEMYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQ 209

  Fly   200 RLCAALLHRS---DRNSYVP----IESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCL 257
            |||.|||...   ...|.:|    :..|.:...:|.|.|.|.|||:|:..|.::|.....||:||
 Frog   210 RLCNALLRPQTFPQNGSLLPAKNSLAQLKETGSAFEVEHDCLGKCQGLFAPHLFSQPDAPCIQCL 274

  Fly   258 ECDGWFSPQKFVGHVHRKFENHTCHWGFDSRNWHDYLHVA---LDVENREKYQIILDQLKEVELK 319
            ||.|.||.|.||.|.||..:..||||||||..||.|:|::   ||....:|...:|.::|
 Frog   275 ECYGMFSTQTFVMHSHRSPDKRTCHWGFDSAKWHCYVHLSPKYLDTPEGKKMNALLKEMK----- 334

  Fly   320 EMHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPPMKQPQMDIPSGKKQ 384
                   |..:||.:.:.:...|             .|  :..|..|...|:.: |.|.|:.:..
 Frog   335 -------EKFNKKNQPKRIQPKG-------------EH--IQTLELPSWYPVIK-QEDDPTSRPH 376

  Fly   385 LQQLKGATVAASALEYQYQVMYAHCVQ--------KEREREREHLPHSHP---LPRQ-----HRA 433
            |       :..|...|.|..:.|..|.        ||.:..|:.:..|.|   |.:|     |::
 Frog   377 L-------LHPSYYLYMYDKVVAPNVSLTATVSQCKEAKIGRKEVAPSKPSVELEKQARSGKHKS 434

  Fly   434 VLVATTPYPHL-----PQYPTPPTLNSSSAFRPWGPD------------------------TTKA 469
            |    |.||.|     .:....|.:.:|:..:|...|                        ..|.
 Frog   435 V----TSYPELSIEEQERVDLKPDIKTSNIKQPNTVDGEKHESACNKDILCVDDKSQIMEEVVKT 495

  Fly   470 FLHAYGATLSSLPYACQEPPEL--------------------QNPERVVRSTDKRY---AERTYQ 511
            ||...    ..|.|..|:..::                    ||.::...|....:   .|..|.
 Frog   496 FLKQQ----EKLNYILQKKQQIQMEVELLSNSKTMKDLTVEQQNLQKEFESLQNEHMQKMEELYD 556

  Fly   512 PNVALAPR-KSI--------LSKERDKDRERMEREVMERQRLREKETDHQVV--HIKQER 560
            ....|..: |.:        |:.:|||:.:...:....||||.:.|.|.:.:  .:::||
 Frog   557 EQRDLEEKLKQVKKQKCSCDLNTDRDKETQYANQLTELRQRLDQAEADRRELQDELRRER 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	54/89 (61%)
		c-SKI_SMAD_bind	226..317	CDD:198114	42/93 (45%)
		AF-4	637..>789	CDD:461550
skil	XP_002931592.1	DHD_Sno	119..218	CDD:410787	60/113 (53%)
		c-SKI_SMAD_bind	243..338	CDD:198114	43/106 (41%)
		SMC_prok_B	<417..633	CDD:274008	39/208 (19%)