Protein Alignment Snoo and skor1

DIOPT Version :10

• Sequence 1: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: XP_012814921.1
• Gene: skor1 / 100491438
• XenbaseID: XB-GENE-877133
• Length: 742
• Species: Xenopus tropicalis
• Alignment Length: 907
• Identity: 206/907 - (22%)
• Similarity: 304/907 - (33%)
• Gaps: 297/907 - (32%)

  Fly    94 PATPP--RELSQPILSVADAGC---GELYETKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLE 153
            |::||  ::...|..:....|.   .::.||.|.|..|....:.|:.||||.|..|.:|..:|..
 Frog    10 PSSPPTSKQHQSPQENQTFTGSLKPNQVGETCLYGVPIVSLVIDGQERLCLAQISNTLLKSYSYN 74

  Fly   154 QINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALL--HRSDRNSYVP 216
            :|:.....|||.|.|||..||...:.|..:|...:..|:||:.:|||||.:.|  ||..:   :|
 Frog    75 EIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGEHRPPK---LP 136

  Fly   217 IESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFENHTC 281
             |:.|     |.|.|:|...|.|...|..|:..:..||||..|..:|||.||:.|.||.
 Frog   137 -ENFA-----FDVAHECAWGCRGSFIPARYNSSRAKCIKCAYCGLYFSPNKFIFHSHRT------ 189

  Fly   282 HWGFDSRNWHDYLHVALDVENREKYQIILDQLKEVELKEMHKAQRELEHKKRKAEMLMDDGML-- 344
                     .|..:...|..|...::      :.:.|.:...:. :|.|.....:.:.:.|..
 Frog   190 ---------PDSKYTQPDAANFNSWR------RHLRLNDTTPSD-DLSHSWEDVKAMFNGGTRKR 238

  Fly   345 -----GSGPVLGLAGHPHGLVGALAPPPPPPMKQPQMDI--PSGKKQLQQLKGATVAASALEYQY 402
                 .|......:...|   ..||||||||   |...:  ||.:::    .|||.|.|     :
 Frog   239 AFPSPASSSSSSSSARRH---LELAPPPPPP---PAKALRGPSAEEE----SGATAARS-----F 288

  Fly   403 QVMYAHCVQKEREREREHLPHSHPLP-RQHRAVLVATTPYPHLPQYPTPP--------------- 451
            .::                    |:| :....||....|    |.:|.||
 Frog   289 PLI--------------------PVPSKGFSGVLHKMGP----PLFPPPPYGFPAFGLCAKKDDG 329

  Fly   452 -------TLNSSSAFRPWGPDTTKA-------FLHAYGATLSSLPY-------------ACQEPP 489
                   .......|.|..|.:..:       |..|....|...||             |....|
 Frog   330 GLGDAGKAAGLPGVFWPTAPASKDSVYPPFPVFWPAAAGALPVPPYTGLTQQQQVPGKSAVVGEP 394

  Fly   490 ELQNPERVVRSTDKRYAERT----YQPNVALAPRK-SILSKERD--KDRERM-----EREVMERQ 542
            |...|.........|..||:    .||...|.||| ..:|..|.  |..|.:     .||:....
 Frog   395 EEAEPSGETAEEPTREEERSGDEGRQPGEPLTPRKLRYISAFRPVVKAAESLAKLYGSRELYGAA 459

  Fly   543 RLREKETDHQVVHIKQERSQTPTPPTASPPDGVVLPLDVVEPPHPSSSGSNSPLPAHLPAAPATA 607
            |.....:...:......||.:|:|.||..|:     :||       .||
 Frog   460 RAAGYSSPDLLSDTSSYRSASPSPDTADEPE-----VDV-------ESG---------------- 496

  Fly   608 PPNAGGAPPTPTNLRNMRSPEEFSA-------GGSNEITSSTSPHHQQSSHHQVVQPTAGAPPPS 665
                             |.|||.||       |.|:.|:|..|...         :|:.|..|.|
 Frog   497 -----------------RFPEEESAQLGSLGPGASSSISSPGSERR---------EPSPGGSPAS 535

  Fly   666 QHIIATVNQHAKLLPSSSSLPNGNGSSSLAATNNEPSRIRINKNLMSQQPVVAVSGMTPHHHQHH 730
               :|....:||.:.....|..||.|                                   ||
 Frog   536 ---VAGYEVYAKQMTDLPHLMKGNSS-----------------------------------HQ-- 560

  Fly   731 PTHMHHFSHGYYKSQASSPTQSSSAGLNLSTHSSNVVSSPHHATQPKTHHSSVGSGNHGLQNGKP 795
                               ..|||...||..:..:  |...|:|..:.      ......|:.:.
 Frog   561 -------------------GVSSSYLCNLDPNEQD--SEDSHSTAEEL------DSRKAFQDPRS 598

  Fly   796 HLGSEFELSTDTDDTDSLNGEPDSSAMLPPWE----QAVESLRETRPKDRERVLLI----LQRLL 852
            ||.....|.||       .||.||     |.:    |.||...|...||..:.||:    |::.|
 Frog   599 HLSHTSPLHTD-------RGEEDS-----PIDVTGTQFVEKDIENMAKDELQKLLVEQMDLRKKL 651

  Fly   853 QENDQYRYNNIQLSELLHKQDAHIADLTEQLQRYRRQFEEQVC-KVDL-RKMPFKHQTRLEN 912
            :...|...:|.|  :.:.::.|:..::.:|||..|    :.:| ::|. ||..:..|.:|::
 Frog   652 EREFQSLKDNFQ--DQMKRELAYREEMVQQLQIVR----DTLCNELDQERKARYAIQQKLKD 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	34/89 (38%)
		c-SKI_SMAD_bind	226..317	CDD:198114	24/90 (27%)
		AF-4	637..>789	CDD:461550	24/151 (16%)
skor1	XP_012814921.1	DHD_Skor	37..127	CDD:410783	34/89 (38%)
		c-SKI_SMAD_bind	140..232	CDD:198114	28/118 (24%)
		PRK10263	<341..>500	CDD:236669	40/203 (20%)
		OmpH	625..>708	CDD:461098	23/89 (26%)