Protein Alignment Snoo and skor2

DIOPT Version :10

• Sequence 1: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: XP_031750790.1
• Gene: skor2 / 100488414
• XenbaseID: XB-GENE-29099423
• Length: 727
• Species: Xenopus tropicalis
• Alignment Length: 684
• Identity: 151/684 - (22%)
• Similarity: 232/684 - (33%)
• Gaps: 173/684 - (25%)

  Fly    83 STRGTPPQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMRLCLPQFLNNVL 147
            ||..|.||        ..|||.....:.....::.:..|.|..|....:.|:.||||.|..|.:|
 Frog    16 STASTYPQ--------DSLSQSRSGHSGMKPNQVSQVILYGIPIVSLVIDGQERLCLAQISNTLL 72

  Fly   148 NDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALLHRSDRN 212
            .::|..:|:.....|||.|.|||..||...:.|..:|...:..|:||:.:|||||.:.| ..:|.
 Frog    73 KNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFL-GENRP 136

  Fly   213 SYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHR--- 274
            ..:|      ...:|.|.|:|...|.|...|..|:..:..||||..|:.:|||.||:.|.||
 Frog   137 PKLP------DNFAFDVSHECAWGCRGSFIPARYNSSRAKCIKCTYCNMYFSPNKFIFHSHRTPE 195

  Fly   275 ---------KFENHTCHWGFDSRN--------W-----------------HDYLHVALDVENREK 305
                     .|.:...|.....:.        |                 |.:.|....|::...
 Frog   196 AKYMQPDAANFNSWRRHLKLSDKTPSDDMVFAWEDVKAMFNGGSRKRALSHGHCHSISSVKSSTG 260

  Fly   306 YQIILDQLKEVELKEMH---KAQRELE-----HKKRKAEMLM-----DDGMLGSGPVLGLAGHPH 357
               ||..:...:|.:..   :.:.|||     .|.:::..::     ..|||...|...|..:|:
 Frog   261 ---ILPHMIGQDLNQKRPRFEEEEELETSNLPSKTQRSYPVIPVPSKGFGMLQKFPASTLFPNPY 322

  Fly   358 -------------------------------GLVGALAPP-------------PPPPMKQPQ--- 375
                                           |...|..||             |.|...|||
 Frog   323 TFPAFGLCQKKDDSDSVNSQKTSALSGLFWPGRKDAFYPPFCMFWPPRTPGGLPVPTYLQPQPSA 387

  Fly   376 ----MDIPSGKKQLQQLKGATVAASALEYQYQVMYAHCVQKEREREREHLPHSHPLPRQHRAVLV 436
                .:.||.::...:|...:..:|.......:....|             .|.|:....||...
 Frog   388 LTSITENPSLRQAFLELSDQSDGSSISNAGDNLFETEC-------------SSSPVAGDIRASSE 439

  Fly   437 ATTPYPHLPQYPTPPTLNSSSAFRPWGPDTTK-AFLHAYGATLSSLPYACQEPPELQNPERVVRS 500
            ..|....:|.:|.... |..|||||...|... |.||.                   |.|..  :
 Frog   440 GRTNILDVPPFPIRKQ-NYHSAFRPVVKDAESIAKLHG-------------------NMEDF--A 482

  Fly   501 TDKRYAERT---YQPNVALAPRKSILSKERDKDRERMEREVMERQRLREKETDHQVVHIKQERSQ 562
            :|:..:..|   ||.:.:.:..:..:..|.:|.::..|.|.:..|.|:.:..........:|||.
 Frog   483 SDRHISPGTSCSYQSDSSDSDEEQEVDVESNKQQDDEEEETLSSQFLQSRGLSESADKTLKERSP 547

  Fly   563 TPTPPTASPPDGVVLPLDVVEPPHPSSSGSNSPLPAHLPAAPATAPPNAGGAPPTPTNLRNMRSP 627
            .|||.....||         .|.:.||:......|.|    .:...|....|..|..:..::.|.
 Frog   548 YPTPRNEEKPD---------SPENLSSATPKDSSPRH----TSLEEPCCKDAQKTKEDSASLSSK 599

  Fly   628 EEFSAGGSNEITSSTSPHHQQSSHHQVVQPTAGA 661
            |:.....|.|:  ...|...:.|..:..:..|||
 Frog   600 EDCFPDKSKEM--HFFPTESEPSGGEFWRELAGA 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	32/89 (36%)
		c-SKI_SMAD_bind	226..317	CDD:198114	29/127 (23%)
		AF-4	637..>789	CDD:461550	6/25 (24%)
skor2	XP_031750790.1	DHD_Skor	41..131	CDD:410783	32/89 (36%)
		c-SKI_SMAD_bind	144..236	CDD:471667	24/91 (26%)