Protein Alignment Snoo and skor1a

DIOPT Version :10

• Sequence 1: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: NP_001124124.1
• Gene: skor1a / 100170817
• ZFINID: ZDB-GENE-080722-5
• Length: 751
• Species: Danio rerio
• Alignment Length: 942
• Identity: 198/942 - (21%)
• Similarity: 316/942 - (33%)
• Gaps: 271/942 - (28%)

  Fly    93 SPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINR 157
            ||:: .:|| ||....:.....::.||.|.|..|....:.|:.||||.|..|.:|.::|..:|:.
Zfish    17 SPSS-KQEL-QPYSGSSSMKPNQVSETALYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHN 79

  Fly   158 IFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALL--HRSDRNSYVPIESL 220
            ....|||.|.|||..||...:.|..:|...:..|:||:.:|||||.:.|  |...:   :| |:.
Zfish    80 RRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGAHNPPK---LP-ENF 140

  Fly   221 AKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFEN-HTCHWG 284
            |     |.|.|:|...|.|...|..|:..:..||||..|:.:|||.||:.|.||..|: :|....
Zfish   141 A-----FDVSHECAWGCRGNFIPARYNSSRAKCIKCTYCNMYFSPNKFIFHSHRTPESKYTQPDA 200

  Fly   285 FDSRNWHDYLHVALDVENREKYQIILDQLKEVELKEMHKAQRELEHKKRKAEMLMDDG-----ML 344
            .:..:|..:|                 :|.:..|.:      :|.|.....:.:.:.|     |.
Zfish   201 ANFNSWRRHL-----------------KLTDKSLAD------DLCHAWEDVKAMFNGGSRKRAMP 242

  Fly   345 GSGPVLGLAGHPHGLVGALAPPPPPPMKQ-PQMDIPSGKKQLQQLKGATVAASALEYQYQVMYAH 408
            |||.  .::.|       |.|.....:.| ...|||....:....:|....::::. .|.|:
Zfish   243 GSGS--EMSSH-------LKPQSSGNITQTTSSDIPHKTLRCDDDRGNLSLSNSVR-NYPVI--- 294

  Fly   409 CVQKEREREREHLPHSHPLPRQHRAVLVATTP--YPHLPQYPT-------------PPTLNSSSA 458
                             |:|.:...:|....|  :||...:|.             ....|..|.
Zfish   295 -----------------PVPSKSFGMLQKIPPPIFPHPYSFPAFGLCQKKDDGVGEQNKTNVPSV 342

  Fly   459 FRPWGPDTTKAFLHAYGATLSSLPYACQEPPELQNPERVV---RSTDKRYAERTYQPNVALAPRK 520
            |.|...|........:..|..|||.:..:|    .|...:   |.|:...:|.....|   .||.
Zfish   343 FWPGAKDGIYPSFPMFWPTAGSLPLSSYQP----KPHADLLGGRQTEAEISESERGGN---TPRD 400

  Fly   521 SILSKER---------DKDRERMEREVMERQRLREKETDHQVVHIKQERSQTPTPPTASPPDGVV 576
            |:...||         |:|:...|....|.|    ..|..::.:|...|      |.....:.:.
Zfish   401 SLFDSERCSSSQSLRNDEDKSGDEARSSEGQ----PSTPRKLSYISAFR------PVVKDAESIA 455

  Fly   577 L---PLDVVEPPHPSSSGSNSPLPAHLPAAPATAPPNAGGAPPTPTNLRNMRSPE-----EFSAG 633
            .   ..|.....||   |..||......::..:|.|.|........::...|.|:     :.|..
Zfish   456 KLYGNRDAYSGAHP---GHLSPDFVSESSSYRSASPCADSGEEPDVDVETHRIPDDEESIQLSVD 517

  Fly   634 GSNEITSSTSPHHQQSSHHQVVQ-PTAGAPPPSQHIIATVNQHAKLLPSSSSLPNGNGSSSLAAT 697
            .........:|..|....||.|. ..:|:|...|
Zfish   518 DRQSPVREDTPTPQPDDDHQTVTFSDSGSPDHKQ------------------------------- 551

  Fly   698 NNEPSRIRINKNLMSQQPVVAVSGMTPHHHQHHPTHMHHFSHGYYKSQASSPTQSSSAGLNLSTH 762
                     ||.:..:...:|           :..:.|.      |..||.....|.:...||..
Zfish   552 ---------NKQVAKKSDAIA-----------YDVYSHE------KDGASLQNTLSCSASKLSRC 590

  Fly   763 SSNVVSSPHHATQPKTHHSSVGSGNHGLQNGKPHLGSEFELSTDTDDTDSLNGEPDSSAMLPPWE 827
            :.:.                                ::..:|..|||      |.:|.      :
Zfish   591 AQDT--------------------------------NDSHISNSTDD------ECESQ------K 611

  Fly   828 QAVESLRETRPKDRERVLLILQRLLQENDQYRYNNIQLSELLHKQDAHIADLTEQLQRYRRQFEE 892
            ...:.:|.:|...       :...|:..|. |:|       ..|...::|  .|:||   :|..|
Zfish   612 SCSDQIRVSRENS-------IDAALRSTDN-RFN-------FEKDIENMA--KEELQ---KQLLE 656

  Fly   893 QVCKVDLR-KMPFKHQTRLENVVEAGRGEAEEDEEL------------EEDEMEDRANNNNQQEL 944
            |   |:|| |:..:.|:..:|..:..:.|....||:            .|.:.|.:|....||:|
Zfish   657 Q---VELRKKLEREFQSLKDNFQDQMKRELSYREEMVQQLQIVRDTLCNELDQERKARYAIQQKL 718

  Fly   945 SPLIKAPANGLRRSVTPPNCCASEGGDCE-KP 975
            .....|..:...:.:||.:|.    |.|. ||
Zfish   719 KEAHDALHHFSCKMLTPRHCT----GTCTFKP 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	34/89 (38%)
		c-SKI_SMAD_bind	226..317	CDD:198114	26/91 (29%)
		AF-4	637..>789	CDD:461550	18/152 (12%)
skor1a	NP_001124124.1	DHD_Skor	38..128	CDD:410783	34/89 (38%)
		c-SKI_SMAD_bind	141..233	CDD:471667	30/119 (25%)
		Tektin	<598..727	CDD:460827	36/163 (22%)