Protein Alignment CG34345 and P4HA2

DIOPT Version :10

• Sequence 1: NP_001097101.1
• Gene: CG34345 / 5740402
• FlyBaseID: FBgn0085374
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 145/546 - (26%)
• Similarity: 239/546 - (43%)
• Gaps: 76/546 - (13%)

  Fly    13 WI---LLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRI 74
            |:   |:..|.|....:||        :..||..:::|...|...::.|..|:...:.|:..::.
Human     4 WVSALLMAWFGVLSCVQAE--------FFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKS 60

  Fly    75 FINSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKL-IAYLKDQ--GNIKVDIEEMNKLIN 136
            :.|.:.........|...|:::|:|::.|::|.:.|||.| ...|:|.  |.|      .|..:.
Human    61 WANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFI------ANLSVQ 119

  Fly   137 RTPHANDMEE--ALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRR 199
            |.....|.:|  |...:.|::..|.|....:::|.:.|.:..:.:|..||..:....|...::..
Human   120 RQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYH 184

  Fly   200 AAEWYRIALSVF------TKPKNNIA-FKFYAP-KRKELEKMFVISR------------------ 238
            ...|....|...      |..|:.:. :..||. :..:|.:...::|
Human   185 TVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRY 249

  Fly   239 ----LQEGSVENLTDCLKELSQDPNNSLVHLRP---RKSPTMIEQGCQG---KFPPGPQ--LVCR 291
                |:|...:.||:..:.....|..  ::.||   .....:.|..|:|   |..|..|  |.||
Human   250 FEQLLEEEREKTLTNQTEAELATPEG--IYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCR 312

  Fly   292 Y-NSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTREEMILGTTTNYTT------ 349
            | :....|.:.|||.|||:....|.|..|:||:.|.||.::..:.:.::...|..:..|
Human   313 YHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVA 377

  Fly   350 PDRVNRLFHIKVTDDDGGKLDKTLVNRMADISGLDVGNTTTLARINYGLGGYFQEHSDYM---DI 411
            ..||::...::..||   .:...:..||..|:||.|.....|...|||:||.::.|.|:.   :.
Human   378 SYRVSKSSWLEEDDD---PVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDER 439

  Fly   412 KLYPELTEEGDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAV 476
            ..:..| ..|:|:.|||.||:||..||.|:||....||.||||:|:|||||..:|:.:..||||.
Human   440 DTFKHL-GTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAA 503

  Fly   477 CPTIVGSRWVLVKSMLNYEQMFKKPC 502
            ||.:||.:||..|......|.|.:||
Human   504 CPVLVGCKWVSNKWFHERGQEFLRPC 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..172	CDD:462433	31/136 (23%)
		P4Hc	324..489	CDD:214780	61/173 (35%)
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	31/136 (23%)
		BamD	159..>272	CDD:443281	16/112 (14%)
		TPR	207..240		4/32 (13%)
		P4Hc	346..519	CDD:214780	62/176 (35%)