DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34345 and P4HA2

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens

Alignment Length:	546	Identity:	145/546 - (26%)
Similarity:	239/546 - (43%)	Gaps:	76/546 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WI---LLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRI 74
            |:   |:..|.|....:||        :..||..:::|...|...::.|..|:...:.|:..::.
Human     4 WVSALLMAWFGVLSCVQAE--------FFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKS 60

  Fly    75 FINSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKL-IAYLKDQ--GNIKVDIEEMNKLIN 136
            :.|.:.........|...|:::|:|::.|::|.:.|||.| ...|:|.  |.|      .|..:.
Human    61 WANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFI------ANLSVQ 119

  Fly   137 RTPHANDMEE--ALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRR 199
            |.....|.:|  |...:.|::..|.|....:::|.:.|.:..:.:|..||..:....|...::..
Human   120 RQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYH 184

  Fly   200 AAEWYRIALSVF------TKPKNNIA-FKFYAP-KRKELEKMFVISR------------------ 238
            ...|....|...      |..|:.:. :..||. :..:|.:...::|
Human   185 TVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRY 249

  Fly   239 ----LQEGSVENLTDCLKELSQDPNNSLVHLRP---RKSPTMIEQGCQG---KFPPGPQ--LVCR 291
                |:|...:.||:..:.....|..  ::.||   .....:.|..|:|   |..|..|  |.||
Human   250 FEQLLEEEREKTLTNQTEAELATPEG--IYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCR 312

  Fly   292 Y-NSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTREEMILGTTTNYTT------ 349
            | :....|.:.|||.|||:....|.|..|:||:.|.||.::..:.:.::...|..:..|
Human   313 YHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVA 377

  Fly   350 PDRVNRLFHIKVTDDDGGKLDKTLVNRMADISGLDVGNTTTLARINYGLGGYFQEHSDYM---DI 411
            ..||::...::..||   .:...:..||..|:||.|.....|...|||:||.::.|.|:.   :.
Human   378 SYRVSKSSWLEEDDD---PVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDER 439

  Fly   412 KLYPELTEEGDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAV 476
            ..:..| ..|:|:.|||.||:||..||.|:||....||.||||:|:|||||..:|:.:..||||.
Human   440 DTFKHL-GTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAA 503

  Fly   477 CPTIVGSRWVLVKSMLNYEQMFKKPC 502
            ||.:||.:||..|......|.|.:||
Human   504 CPVLVGCKWVSNKWFHERGQEFLRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	31/134 (23%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	61/173 (35%)
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	31/134 (23%)
		TPR	207..240		4/32 (13%)
		P4Hc	346..519	CDD:214780	62/176 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020