DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34345 and p4ha3

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_021322008.1	Gene:	p4ha3 / 563281	ZFINID:	ZDB-GENE-041010-4	Length:	616	Species:	Danio rerio

Alignment Length:	523	Identity:	127/523 - (24%)
Similarity:	228/523 - (43%)	Gaps:	101/523 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIF---INSLTPNYLDHKVDRYKYVSNPLNSF 101
            |:.::::....|...::||..|:....|:::.::.|   :.||.....:...|.   ::||:.:|
Zfish    27 SMLSVNQAVSAERKLIDHLIIYIEHEAQRLEDIKRFFSRVTSLHDGIYNEPSDP---IANPIAAF 88

  Fly   102 GLLRRAHQDWPKLIAYLKDQGNIKVDIEEMNKLINRTPHANDMEEALMGMDRIEHFYDLKSSDMA 166
            .|::|...:|..::...:.:.||||..|:..::.:..|...|:..|..|:.|::..|:|.    .
Zfish    89 KLVKRLKSEWLNVVHSTEAEENIKVLREDYRRMESSLPKLEDLRGAAHGLMRLQDVYNLH----V 149

  Fly   167 QGLVAG--QQL-----------SSRMSASDCLALADYMYKRSEFRRAAEWYRIALSVFT----KP 214
            :.||.|  ||:           |..:|..||..:....|...::..:..|:..|:.:|.    .|
Zfish   150 ESLVRGHFQQISDPVDFYKLSVSDMLSGDDCFLVGKVAYDLEDYYHSVLWFEEAVRLFRGTEWSP 214

  Fly   215 KN---------NIAFKFYAPKRKELEKMFVISRLQEGSVENLTDCLKE-LSQDPNNSLVHLRPRK 269
            :|         ::||                |..:.|::.:.....:| |..||.|..||....|
Zfish   215 ENEGTLEDALDHLAF----------------SHFKTGNISHALSLSRELLLHDPMNRRVHFNVEK 263

  Fly   270 SPTMI---------------------------EQGCQ--GKFP---PGPQLVCRYNSTTTPFMRI 302
            ...::                           ||.||  |..|   ..|.|.|.|.:..:|.:.:
Zfish   264 YEKLLNENLPATSSGLTLKRPDGIYLRTRNAYEQLCQTKGSQPKHFENPSLFCDYFTNGSPALFL 328

  Fly   303 APLKEEEISRDPLIWLYHDVIYDSEIAQLTNVT----REEMILGTTTNYTTPDRVNRLFHIKVTD 363
            .|::.|.||..|.:.|:|..:..:|...:....    |..::.......|...|:::...:|.:.
Zfish   329 QPIRREIISLQPYVVLFHGFVTQAEAKNIRKYAMPGLRRSVVASGMNQATAEYRISKSAWLKESA 393

  Fly   364 DD-GGKLDKTLVNRMADISGLDV--GNTTTLARINYGLGGYFQEHSDYM---DIKLYPELTEEGD 422
            .: .||||:    |:..::||:|  .....|..:|||:||:::.|.|:.   ...||...|  |:
Zfish   394 HEVVGKLDQ----RITLVTGLNVQPPYAEYLQVVNYGIGGHYEPHFDHATSDSSPLYRLKT--GN 452

  Fly   423 RLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAVCPTIVGSRWVL 487
            |:.|.:.|::.|..||:|.|..|..::...:.:||||:|||.||..|:.|.||.||.|||::|.:
Zfish   453 RVATIMIYLSPVQAGGSTAFIYANFSVPVVQNAALFWWNLHKNGQGNVDTLHAGCPVIVGNKWGM 517

  Fly   488 VKS 490
            .|:
Zfish   518 FKN 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	28/132 (21%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	53/174 (30%)
p4ha3	XP_021322008.1	P4Ha_N	27..157	CDD:311993	31/136 (23%)
p4ha3	XP_021322008.1	P4Hc	350..519	CDD:214780	53/174 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583403
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1438683at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850