Protein Alignment CG34345 and P4HA1

DIOPT Version :9

• Sequence 1: NP_001097101.1
• Gene: CG34345 / 5740402
• FlyBaseID: FBgn0085374
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_000908.2
• Gene: P4HA1 / 5033
• HGNCID: 8546
• Length: 534
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 143/541 - (26%)
• Similarity: 241/541 - (44%)
• Gaps: 108/541 - (19%)

  Fly    37 YSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIFINSLTPNYLDHKVDRYKYVSNPLNSF 101
            :..||..:::|...|...:..|.:|:...:.|::.::.:...|.........|...:|.:|:|:|
Human    21 FFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAF 85

  Fly   102 GLLRRAHQDWPKL-IAYLKDQGNIKVDIEEMNKLINRTPHANDMEE--ALMGMDRIEHFYDLKSS 163
            .|::|.:.:|.:| ...|||..:..:.    |..|.|....||.::  |...:.|::..|:|.:.
Human    86 KLMKRLNTEWSELENLVLKDMSDGFIS----NLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTD 146

  Fly   164 DMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAEWYRIALSVFTKPKNNIAFKFYAPKRK 228
            .:::|.:.|.:..|.::|.||..|....|..:::.....|...||....:.:.:
Human   147 TISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEIS----------- 200

  Fly   229 ELEKMFVISRL-----QEGSVEN---LTDCLKELS---QDPNNSLVHLR---------------- 266
            .::|:.|:..|     |:|.::.   ||..|.||.   |..|.:|.:..
Human   201 TIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDD 265

  Fly   267 -------PRKSPTMI---------EQGCQG---KFPPGPQ--LVCRY-NSTTTPFMRIAPLKEEE 309
                   |:|....:         |..|:|   |..|..|  |.||| :....|...:||.|:|:
Human   266 QSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQED 330

  Fly   310 ISRDPLIWLYHDVIYDSEIAQLTNVTREEMILGTTTNYTTPDRVNRLFHIKVTDDDGGKL----- 369
            ....|.|..:||:|.|:||..:.::.:.                 ||....|.|.:.|||
Human   331 EWDKPRIIRFHDIISDAEIEIVKDLAKP-----------------RLSRATVHDPETGKLTTAQY 378

  Fly   370 -----------DKTLVN----RMADISGLDVGNTTTLARINYGLGGYFQEHSDYMDIKLYPELTE 419
                       :..:|:    |:.|::||||.....|...|||:||.::.|.|:.. |..|:..:
Human   379 RVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFAR-KDEPDAFK 442

  Fly   420 E---GDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAVCPTIV 481
            |   |:|:.|:||||:||..||.|:||....::.||||:|:|||||..:|:.:..||||.||.:|
Human   443 ELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLV 507

  Fly   482 GSRWVLVKSMLNYEQMFKKPC 502
            |::||..|.:....|.|::||
Human   508 GNKWVSNKWLHERGQEFRRPC 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	30/132 (23%)
		P4Hc	324..489	CDD:214780	63/187 (34%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	19/86 (22%)
		TPR	205..238		9/32 (28%)
		P4Hc	345..518	CDD:214780	64/190 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920