DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34345 and CG15864

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	173/532 - (32%)
Similarity:	260/532 - (48%)	Gaps:	88/532 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YILLNWILLFLFTVC----------KAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYV 62
            |||.|..|:...:.|          ..||:         |:.|...|.:|.|:|:..:::|..||
  Fly     2 YILKNLTLIGFLSACFINCQGFVKSNPKKS---------YAASTMELMKLLEVEDELVDNLKGYV 57

  Fly    63 SFLQQKIKTLRIFINSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKLIAY-LKDQGNIKV 126
            ..|:.|...:...:..::...::.|.|...|:.||||||.|:.|.|..|.|...| :|.:.|...
  Fly    58 KTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALG 122

  Fly   127 DIEEMNKLINRTPHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAG-QQLSSRMSASDCLALADY 190
            .||....:....|.::|:::|..|:..:..|||||..::|.|.:|| .|..:.::|.|||||.::
  Fly   123 HIENARLMRKMLPTSSDLQQACRGIHDLMSFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEF 187

  Fly   191 MYKRSEFRRAAEWYRIAL----SVFTKPKNNIAFKFYAPKRKELEKMFVISRLQEGSVENLTDCL 251
            ..::.|...|..||.::|    :.|.|.:.:.|:.....|.|:                 |||..
  Fly   188 SVQKREDDLAEAWYNLSLIRFENKFDKYRVHKAWGLLLAKNKQ-----------------LTDAF 235

  Fly   252 KELSQDP-----NNSLVHLRPRKSPTMIEQGCQGKFPPGPQLVCRYNSTTTPFMRIAPLKEEEIS 311
            ......|     :|.::|.:...|   .:|.|........:|.||||:|||||.||||||.||:.
  Fly   236 YHFENKPEGIIASNEVIHFKEELS---TKQNCAVVVQKPSRLHCRYNTTTTPFTRIAPLKMEELG 297

  Fly   312 RDPLIWLYHDVIYDSEIAQLTNVTREEMILGTTTNYTTPDRVNRLFHIKVTDDDGGKLD------ 370
            .||.:.::||||||:||..:.|.:.                    |.:.:| |.|.|.:
  Fly   298 LDPYMVVFHDVIYDTEIDGMLNSSN--------------------FGLSLT-DSGQKSEVRTSKD 341

  Fly   371 ------KTLVNRMADISGLDVGNTTTLARINYGLGGYFQEHSDYMDIKLYPELT--EEGDRLMTF 427
                  |||..|:.|::|..:..:...:.|||||||::..|.|:.:   |...|  ::|||:.|.
  Fly   342 SYIVDAKTLNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDFHE---YTNTTRPKQGDRIATV 403

  Fly   428 LFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAVCPTIVGSRWVLVKSML 492
            |||:.:|..||.||||...:.:.||||||:|||||||:|..||.:.|:.||.|.||::||.|.:.
  Fly   404 LFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWIN 468

  Fly   493 NYEQMFKKPCYK 504
            ...|||..||.|
  Fly   469 ELPQMFVTPCMK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	40/130 (31%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	65/178 (37%)
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	40/130 (31%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	26/71 (37%)
		P4Hc	313..467	CDD:214780	64/177 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461728
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900