DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34345 and p4ha2

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_012814344.2	Gene:	p4ha2 / 493342	XenbaseID:	XB-GENE-957618	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	551	Identity:	147/551 - (26%)
Similarity:	243/551 - (44%)	Gaps:	81/551 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LNWILLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIF 75
            |:.|.|.|.::|...:.:.:|.      .|...:::|...|...::.|..|:...::::..::.:
Frog     3 LHAISLILLSLCCIWEVQTEVF------TSTGQMTDLIFRERDLLQSLKEYIREEEERLSKIKRW 61

  Fly    76 INSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKLIAYLKDQGNIKVDIEEMNKLINRT-- 138
            .:.:.........|...|:.:|:|::.|::|.:.||..|       .|:.:.......:.|.|
Frog    62 ASEVDELSSRSTADPEGYLGHPVNAYKLVKRFNTDWSSL-------ENLVLQDSAKGFIANFTFQ 119

  Fly   139 ----PHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRR 199
                |...|...|...:.||:..|.|....:|:|.:.|....|.:||.|...:....|...::..
Frog   120 REYFPTEEDETGAARALMRIQDTYKLDPDVIAKGKLPGTNYISSLSADDSFGMGKIAYHDGDYYH 184

  Fly   200 AAEWYRIALSVFTKPKNNIAFKF-------Y-------APKRKELEK-MFVISRLQEGSVENLTD 249
            ...|.:.||....:.::.:..|.       |       .|:..||.| :..:....:.:|.||..
Frog   185 TVLWMQQALKQMDEGEDAVVNKVDVLDYLSYTVFQLGDVPRALELTKRLLALDPNHDRAVNNLKY 249

  Fly   250 CLK-------ELSQDPNNSL--------VHLRP---RKSPTMIEQGCQG---KFPPGPQ--LVCR 291
            ..|       ||.|:.:.:.        |:.||   .....:.|..|:|   |..|..|  |.||
Frog   250 FEKMQEKQKAELKQNESTNTESATRQPGVYSRPLDYLPERDVYEALCRGEGVKMNPRRQRRLFCR 314

  Fly   292 Y-NSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTREEMILGT----------TT 345
            | |...:|::.::|:|.|:....|.|..|.:.:.|.|||::..:.:.::...|          ..
Frog   315 YHNGNRSPYLILSPVKVEDEWDSPRIVRYLNALSDEEIAKIKELAKPKLARATVRDPKTGVLSVA 379

  Fly   346 NYTTPDRVNRLFHIKVTDDDGGKLDKTLVN-RMADISGLDVGNTTTLARINYGLGGYFQEHSDYM 409
            ||    ||::...::..||.    ....|| ||..|:||.|.....|...|||:||.::.|.|:
Frog   380 NY----RVSKSAWLEENDDP----VIARVNLRMQAITGLTVDTAELLQVANYGMGGQYEPHFDF- 435

  Fly   410 DIKLYPELTEE---GDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLL 471
            ..|..|::.:.   |:|:.|||.||:||..||.|:||....||.||||:|:|||||..:|:.:..
Frog   436 SRKDEPDVFKRLGTGNRVATFLNYMSDVEAGGATVFPDFGAAIWPKKGTAVFWYNLFRSGEGDYR 500

  Fly   472 TRHAVCPTIVGSRWVLVKSMLNYEQMFKKPC 502
            ||||.||.:|||:||..|......|.|.:||
Frog   501 TRHAACPVLVGSKWVSNKWFHERGQEFLRPC 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	26/135 (19%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	67/178 (38%)
p4ha2	XP_012814344.2	P4Ha_N	27..113	CDD:400573	14/92 (15%)
		TPR repeat	166..201	CDD:276809	6/34 (18%)
		TPR repeat	206..236	CDD:276809	6/29 (21%)
		P4Hc	348..521	CDD:214780	68/181 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010