DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34345 and PH4alphaPV

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	168/546 - (30%)
Similarity:	272/546 - (49%)	Gaps:	85/546 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILLNW-ILLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTL 72
            :||.: :||.|....|.:::         :..|:..:.:|.::|...:::|.:|...|::|::|:
  Fly    12 VLLTYQVLLLLLRQAKGEES---------HCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTV 67

  Fly    73 RIFINSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKLIAYLKDQGNIKVDIEEMNKLINR 137
            |..|.||.......:....:|:|||||||.|:||.::||.....|:.|...|. .:|.:.:|...
  Fly    68 RRSITSLRLENDKARSSTEEYLSNPLNSFSLIRRMNRDWIIWQLYMDDPVGIS-QVERIQELREH 131

  Fly   138 TPHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAE 202
            .|...|:|||:..:|||:..|.||..:::.|.:.|:|.:..::..|..|:...::.:..:..||.
  Fly   132 MPTHTDVEEAVTALDRIQSTYGLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAAS 196

  Fly   203 WYRIALSVFTKPKNNIAFKFYAP---KRKELEKMFVISRLQEGSVENLTDCLK----ELSQDPNN 260
            |  |..||....    ||...||   .:.|:..::..:.|:   :....|.||    .|:.:|::
  Fly   197 W--IYQSVVLME----AFSMAAPLEISKNEVRMVYAETLLK---LNQHADALKVVNIALTDNPHD 252

  Fly   261 SLVHLRPRKS-----------------------PTMIEQGCQGKFPPG--PQLVCRYNSTTTPFM 300
              :.|..:||                       ||..:.||:|:|||.  .:|.|.||.||:||:
  Fly   253 --IKLLLKKSEIETMIRTGTNNAPPVKVQATGVPTAYQIGCRGQFPPSADSKLYCLYNRTTSPFL 315

  Fly   301 RIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVT---------------REEMILGTTTNYT-T 349
            .:||||.|.:..||.:.|||||:...||.:|..:.               |.|::...|:... .
  Fly   316 ILAPLKMELVGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWF 380

  Fly   350 PDRVNRLFHIKVTDDDGGKLDKTLVNRMADISGLDVGNTTTLARINYGLGGYFQEHSDYMDIKLY 414
            ||..|             .|...|..|::|::|.::..:..|..:||||||::.:|.|:.: |..
  Fly   381 PDGYN-------------PLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFN-KTN 431

  Fly   415 PELTE-EGDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAVCP 478
            ..:|. .|||:.|.|||:|||..||.|:||..:.|:.|::||.:.||||.:||..:..|.||.||
  Fly   432 SNMTAMSGDRIATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACP 496

  Fly   479 TIVGSRWVLVKSMLNYEQMFKKPCYK 504
            .||||:||..|.:...||:|.:||.|
  Fly   497 VIVGSKWVCNKWIREREQIFSRPCLK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	42/129 (33%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	61/181 (34%)
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	42/129 (33%)
		TPR_11	179..250	CDD:290150	17/79 (22%)
		TPR repeat	179..213	CDD:276809	9/39 (23%)
		TPR repeat	218..248	CDD:276809	6/32 (19%)
		P4Hc	339..510	CDD:214780	62/184 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461765
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910