DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34345 and PH4alphaNE1

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	151/556 - (27%)
Similarity:	247/556 - (44%)	Gaps:	112/556 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIFINSL 79
            |:||.       |:..:..:  |.:||..|.:|...|......|.:.|:.:|..::.|...::|:
  Fly    10 LIFLL-------AQGSLASD--YFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSSI 65

  Fly    80 TPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKLIAYLKDQGNIKVDIEEMNKLINRT------ 138
            ...:.....|...|::||:|.:.|::|.|.||..:      :|.:::..||||  .|.|
  Fly    66 EKEHTMAASDTENYLTNPVNVYRLMKRLHTDWSLM------EGRVQLMAEEMN--FNATREYGLS 122

  Fly   139 -PHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAE 202
             |...|:|.|.:.:.|::..|.|..:.:|||::.|.:..|.||..||..|...:::..::.....
  Fly   123 YPSQEDVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMEDYNNTKV 187

  Fly   203 WYRIALSVFTKPKNNIAFKF---YAPKRKELEKMFVISRLQEGSVENL-----TDCLKELSQ--- 256
            |.|.::....:..::.....   ..|....|.||       |.:.::|     .|...||||
  Fly   188 WLRESMERLRRQTSHAPSHLAPTSGPDTVTLNKM-------EATAKSLFQLGDFDTAFELSQRVL 245

  Fly   257 --DPNN-----------------SLVHLRPRKSPT--------MIEQGCQGKFPP--GPQLVCRY 292
              ||..                 ..|:| |:.|.:        ..|:.|:|:..|  ..:|.|||
  Fly   246 QFDPKRIRNWHLGDKGTAPPEDIDDVYL-PKHSDSYSLSQEFAKYEKVCRGEVHPIVRQELRCRY 309

  Fly   293 NSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTREEMILGTTTNYTTPDRVNRLF 357
            :....|:..:||||.||.|.||.:..:||::...:|:||..:.                 |.|:.
  Fly   310 SRGNHPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMA-----------------VPRMH 357

  Fly   358 HIKVTDDDGGKLDK-----------------TLVNRMADI---SGLDVGNTTTLARINYGLGGYF 402
            ...|....||:|.|                 |:|..:.|:   :|||......|...|||:||::
  Fly   358 RSTVNPLPGGQLKKSAFRVSKNAWLAYESHPTMVGMLRDLKDATGLDTTFCEQLQVANYGVGGHY 422

  Fly   403 QEHSDYM-DIKLYPELTEEGDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNG 466
            :.|.|:. |...||  .|||:|:.|.:||:::|..||.|.||...:|::|:.|:.|||||||.:.
  Fly   423 EPHWDFFRDPNHYP--AEEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSL 485

  Fly   467 DPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPC 502
            |.:..|:||.||.:.||:|:....:....|.|.:||
  Fly   486 DKDYRTKHAGCPVLKGSKWIGNVWIHEVTQTFARPC 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	37/136 (27%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	59/185 (32%)
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	37/136 (27%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	59/188 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461805
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900