DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34345 and PH4alphaSG2

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	132/559 - (23%)
Similarity:	241/559 - (43%)	Gaps:	103/559 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLRSFHYI----LLNWILLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNY 61
            ||.|...||    |:.|:               .|.....|| |:.::.:|.::|...:....:|
  Fly     1 MLDRHCLYIGIFQLIIWV---------------GVANGEFYS-SVDSMQDLAQVEEELLNATRSY 49

  Fly    62 VSFLQQKIKTLRIFINSLTPNYLDH-------KVDRYKYVSNPLNSFGLLRRAHQDWPKLIAYLK 119
            |...|:::...|.::..:.   .:|       |:|  .|:.:||::|.|::|..:||..||....
  Fly    50 VESQQKQLDFYRRYVEQIK---REHEWATSQLKLD--DYLGHPLHAFRLIKRLVRDWDSLIFEPI 109

  Fly   120 DQGNIKVDIEEMNKLINRT---PHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSA 181
            ...|.:.:.....::::|.   |..::::.|:.|:.|::..|:|.:||:|.|::.|....|.:..
  Fly   110 LANNAREEFRAFVEVLSRDLGYPDQSELQGAIKGLARLQKVYNLATSDLADGIIGGLNYGSDLRW 174

  Fly   182 SDCLALADYMYKRSEFRRAAEWYRIALSVF-TKPKNNIAFKFYAPKRKELEKMFVISRLQEGSVE 245
            .:|..:...::...|::|:.||.::|..:. ..|:.......|....:|...|   :..:.|:.:
  Fly   175 RECYEIGVQLFDLGEYQRSLEWLQVAFILLRNSPREEKDADHYLSDIREYASM---ANFELGNPK 236

  Fly   246 NLTDCLKE-LSQDPNNSL----VHLRPRKSPTMIEQG-----------CQGKFPP----GPQLVC 290
            .....|.: |...|.:|.    .:|..|.....:::.           |||:..|    |..|.|
  Fly   237 KAARLLSQILESQPTHSAQQTQKYLESRVPGKNVQETKPSWFSNYTRLCQGRRLPEERSGDPLRC 301

  Fly   291 RYNSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQL-TNVTREEMILG------------ 342
            ..:.....:..:|||:.|.:..||.|.:||.::...:|..: ....:|||:..
  Fly   302 YLDGKRHAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAGSGGEGTVR 366

  Fly   343 -------TTTNYTTP--DRVNRLFHIKVTDDDGGKLDKTLVNRMADISGLDVGNTTTLARINYGL 398
                   |..:|.:|  :.|.|:...                    :||.|:.....:...|||:
  Fly   367 DLRVSQQTWLDYKSPVMNSVGRIIQF--------------------VSGFDMAGAEHMQVANYGV 411

  Fly   399 GGYFQEHSDYMDIKLYPELTEEGDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLH 463
            ||.::.|.||.::.|....  ||||:.|.:||::||..||.|:|....:.:.|.||:.:.|:|||
  Fly   412 GGQYEPHPDYFEVNLPKNF--EGDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLH 474

  Fly   464 NNGDPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPC 502
            .:...:..|.||.||.||||:.:....|.:..|.|::||
  Fly   475 RSLHVDARTLHAGCPVIVGSKRIGNIWMHSGYQEFRRPC 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	32/139 (23%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	50/186 (27%)
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	32/139 (23%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	50/189 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461781
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910