DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34345 and CG18233

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	177/509 - (34%)
Similarity:	280/509 - (55%)	Gaps:	58/509 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIFINSL-TPNYLDHKVDRYK 92
            ||.:....||:|:..|.:|.::|..:|.:.:.|.:.||:|:..|.||:::| .||:..|. :|.|
  Fly    23 NDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDALKRPNHKTHN-EREK 86

  Fly    93 YVSNPLNSFGLLRRAHQDWPKLIAYLKDQGNIKVDIEEMNKLINRTPHANDMEEALMGMDRIEHF 157
            :||||||:|||:||.:||||||..|.:....:: .:..|..:::..|.:.||.|.|..|.|||..
  Fly    87 FVSNPLNAFGLIRRLNQDWPKLQNYTQKPLGLE-QLTAMQDIVSAAPESFDMNEKLKAMHRIETT 150

  Fly   158 YDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAEWYRIALSVFTKPKNNIAFKF 222
            |||:..|:|:||:...:.:.|:...||||||.:.::..||:|:..|::.||.:.|.....|..:.
  Fly   151 YDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLWFQEALKLSTDGSLEIMNRL 215

  Fly   223 YAPKRKELE-KMFVI------------------------SRLQEGSVENLTDCL-KELSQDPNNS 261
                 ||:| |.|..                        |:||:..:.:|...: .||.|..|:.
  Fly   216 -----KEIELKGFATAVAKRSIYLSNQGLTNETIDDMANSQLQDAKLMDLEQLISSELKQWINDD 275

  Fly   262 LVHLRPRKSPTMIEQGCQGKFPPGPQLVCRYNSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDS 326
                 ....||....||:|.||....|||||||:|..|:::||||.|||||||.|.::|:||.|.
  Fly   276 -----STTPPTDHNLGCRGLFPKKSNLVCRYNSSTNAFLKLAPLKMEEISRDPYIVMFHEVISDK 335

  Fly   327 EIAQLT-NVTREEMILGTTTNYTTPDRVNRLFHIKVTDDDGGKLDKTLVNRMADISGLDVGNTTT 390
            :|.::. .:|  ||..|.|:.....:.|:|::.|:    ......|.:..|::|::|..:.....
  Fly   336 DIEEMKGEIT--EMENGWTSLGDPKEIVSRVYWIR----KESSFSKRINQRISDMTGFKLEEFPA 394

  Fly   391 LARINYGLGGYFQEHSDYMDIKLYPELTEE-------GDRLMTFLFYMTDVPVGGTTIFPGAQLA 448
            :...|:|:||||:.|.|:     |.:..:|       |||:.:.:||..:|..||.|:||..::|
  Fly   395 IQLANFGVGGYFKPHYDF-----YTDRLKEVDVNNTLGDRIGSIIFYAGEVSQGGQTVFPDLKVA 454

  Fly   449 IQPKKGSALFWYNLHNNGDPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPC 502
            ::||||:||||:|..::..|:..:.|:|||.:|||||.:.|.:....|:|.|||
  Fly   455 VEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWTITKWLHYAPQLFVKPC 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	52/130 (40%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	55/172 (32%)
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	52/130 (40%)
		ATP-synt_B	<198..278	CDD:304375	17/89 (19%)
		P4Hc	333..498	CDD:214780	56/175 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461789
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910