DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34345 and P4ha2

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	140/571 - (24%)
Similarity:	235/571 - (41%)	Gaps:	117/571 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLRSFHYILLNWILLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFL 65
            :||.|: :.:|:|:....||                   ||..:::|...|...::.|..|:...
  Rat     7 VLLMSW-FGVLSWVQAEFFT-------------------SIGHMTDLIYAEKDLVQSLKEYILAE 51

  Fly    66 QQKIKTLRIFINSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKLIAYLKDQGNIKVDIEE 130
            :.|:..::.:.:.:.........|...|:::|:|::.|::|.:.|||.|       |::.:....
  Rat    52 EAKLSKIKSWASKMEALTSKSAADPEGYLAHPVNAYKLVKRLNTDWPAL-------GDLVLQDAA 109

  Fly   131 MNKLINRT------PHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALAD 189
            ...:.|.:      |...|...|...:.|::..|.|....:::|.:.|.:..:.:|..||..:..
  Rat   110 AGFVANLSVQRQFFPTDEDESGAARALMRLQDTYKLDPDMISRGELPGTKYQAMLSVDDCFGMGR 174

  Fly   190 YMYKRSEFRRAAEWYRIALSVFTKPKNNIAFKFYAPKRKELEKMFVISRL-----QEGSVENLTD 249
            ..|...::.....|....|.           :..|.:...:.|..|:..|     |.|.:....:
  Rat   175 SAYNEGDYYHTVLWMEQVLK-----------QLDAGEEATVTKSLVLDYLSYAVFQLGDLHRAVE 228

  Fly   250 CLKE-LSQDPNNS------------LVHLRPRKSPTMIEQG------------------------ 277
            ..:. ||.||::.            |...|.:......:.|
  Rat   229 LTRRLLSLDPSHERAGGNLRYFERLLEEERGKSLSNQTDAGLASQENLYERPVDYLPERDVYESL 293

  Fly   278 CQG---KFPPGPQ--LVCRY-NSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTR 336
            |:|   |..|..|  |.||| :....|.:.|||.|||:....|.|..|:||:.|.||.::..:.:
  Rat   294 CRGEGIKMTPRRQKRLFCRYHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAK 358

  Fly   337 EEMILGTTTNYTT------PDRVNRLFHIKVTDDDGGKLDKTLVNRMADISGLDVGNTTTLARIN 395
            .::...|..:..|      ..||::...::..||   .:...:..||..|:||.|.....|...|
  Rat   359 PKLARATVRDPKTGVLTVASYRVSKSSWLEEDDD---PVVARVNRRMQHITGLTVKTAELLQVAN 420

  Fly   396 YGLGGYFQEHSDYMDIKLYPELTEE---------GDRLMTFLFYMTDVPVGGTTIFPGAQLAIQP 451
            ||:||.::.|.|:       ..::|         |:|:.|||.||:||..||.|:||....||.|
  Rat   421 YGMGGQYEPHFDF-------SRSDERDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWP 478

  Fly   452 KKGSALFWYNLHNNGDPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPC 502
            |||:|:|||||..:|:.:..||||.||.:||.:||..|......|.|.:||
  Rat   479 KKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	26/135 (19%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	61/179 (34%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	17/83 (20%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	62/182 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920