DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34345 and CG31524

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	149/513 - (29%)
Similarity:	245/513 - (47%)	Gaps:	65/513 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 YSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIFINSLTPNYLDHKVDRYKYVS--NPLN 99
            ::.|:..:.:|..:|:..:..|..|...|..|..|:|..|..:.     .::|:.|...  :..|
  Fly    28 FARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWGIQQMR-----EQLDKSKKEQSFDLFN 87

  Fly   100 SFGLLRRAHQDWPKLIAYL-----KDQGNIKVDIEEMNKLINRTPHANDMEEALMGMDRIEHFYD 159
            .:..:|....||.....||     :|:.|.|    :|:.|  |.|...|:.:|...:.|::..|.
  Fly    88 RYSFIRHMQADWLMWKQYLDKPVIRDELNYK----QMDNL--RMPQELDLFDASEAIRRMQATYA 146

  Fly   160 LKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAEWYRIALSVFTK--PKNNIAFKF 222
            :.|:|:|:|.:.|.|.:|::|..||||:..::..:|.:..|.:|....:....:  |:..:.. .
  Fly   147 MLSNDIAEGFLDGVQYTSKLSPIDCLAMGRHLMNQSRWTIAEQWILAGIKAQDRKGPQTEMIL-L 210

  Fly   223 YAPKRKE----LEKMFVISRLQEGSVENLTDCLK------ELSQDPNN---SLVHLRP----RKS 270
            ..|.:.|    |.|:....|.:||:::.....||      |:.|:..|   .::.|.|    |:.
  Fly   211 RGPTKAELFRTLGKVRFERRNEEGALKAYQAALKHSPHDLEIFQEYQNLKRRVLTLSPSEPIREE 275

  Fly   271 PT-MIEQ-----GCQGKFPPGP----QLVCRYNSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYD 325
            |. .||:     .|.|:. .||    :|.|.||..|.||:|:||:|.|.:|.||.:.|.||::..
  Fly   276 PNDDIEEMELPPCCSGRC-EGPRKLNRLYCVYNCVTAPFLRLAPIKTEILSVDPFVILLHDMVSH 339

  Fly   326 SEIAQLTNVTREEMILGTTTNYTTPDRVNRLFHIKVT--DDDGGKLDKTLVNRMADISGLDVGNT 388
            .|.|.:.:.::.:::...|.|......:.:....|..  |.|..:....|..|:.:.:|||:.::
  Fly   340 KEGALIRSSSKNQILPSETVNAANEFEIAKFRTSKSVWFDSDANEATLKLTQRLGEATGLDMKHS 404

  Fly   389 TTLARINYGLGGYFQEHSDYMDIKLYPELTEEG-------DRLMTFLFYMTDVPVGGTTIFPGAQ 446
            .....||||:||.|:.|.|       ..|.:|.       |||.|.|||:.|||.||.|.|||..
  Fly   405 EPFQVINYGIGGVFESHFD-------TSLADEDRFVNGYIDRLATTLFYLNDVPQGGATHFPGLN 462

  Fly   447 LAIQPKKGSALFWYNLHNNGDPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPCYK 504
            :.:.||.|:.|.|||||..|..::.|.|..||.||||:||:.|.:.:..|.|::||.:
  Fly   463 ITVFPKFGTVLMWYNLHTEGMLHVRTMHTGCPVIVGSKWVVSKWIDDKGQEFRRPCLR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	33/136 (24%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	59/173 (34%)
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	33/136 (24%)
		TPR_11	215..>259	CDD:290150	10/43 (23%)
		TPR_2	216..249	CDD:285020	8/32 (25%)
		P4Hc	340..507	CDD:214780	60/173 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461719
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900