DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34345 and P4ha2

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_006532515.1	Gene:	P4ha2 / 18452	MGIID:	894286	Length:	557	Species:	Mus musculus

Alignment Length:	584	Identity:	146/584 - (25%)
Similarity:	237/584 - (40%)	Gaps:	123/584 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLRSFHYILLNWILLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFL 65
            :||.|: :.:|:|:....||                   ||..:::|...|...::.|..|:...
Mouse     9 VLLMSW-FGVLSWVQAEFFT-------------------SIGHMTDLIYAEKDLVQSLKEYILVE 53

  Fly    66 QQKIKTLRIFINSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKLIAYLKDQGNIKVDIEE 130
            :.|:..::.:.:.:.........|...|:::|:|::.|::|.:.|||.|       |::.:....
Mouse    54 EAKLAKIKSWASKMEALTSRSAADPEGYLAHPVNAYKLVKRLNTDWPAL-------GDLVLQDAS 111

  Fly   131 MNKLINRT------PHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALAD 189
            ...:.|.:      |...|...|...:.|::..|.|....:::|.:.|.:..:.:|..||..|..
Mouse   112 AGFVANLSVQRQFFPTDEDESGAARALMRLQDTYKLDPDTISRGELPGTKYQAMLSVDDCFGLGR 176

  Fly   190 YMYKRSEFRRAAEWYRIALSVFTKPKNNIAFKFYAPKRKELEKMFVISRL-----QEGSVENLTD 249
            ..|...::.....|....|.           :..|.:...:.|..|:..|     |.|.:....:
Mouse   177 SAYNEGDYYHTVLWMEQVLK-----------QLDAGEEATVTKSLVLDYLSYAVFQLGDLHRAVE 230

  Fly   250 CLKE-LSQDPNNS-----------LVHLRPRKS------------------PT-------MIEQG 277
            ..:. ||.||::.           |:.....||                  ||       :.|..
Mouse   231 LTRRLLSLDPSHERAGGNLRYFERLLEEERGKSLSNQTDAGLATQENLYERPTDYLPERDVYESL 295

  Fly   278 CQG---KFPPGPQ--LVCRY-NSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTR 336
            |:|   |..|..|  |.||| :....|.:.|||.|||:....|.|..|:||:.|.||.::..:.:
Mouse   296 CRGEGVKLTPRRQKKLFCRYHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAK 360

  Fly   337 EEMILGTTTNYTT------PDRVNRLFHIKVTDDDGGKLDKTLVNRMADISGLDVGNTTTLARIN 395
            .::...|..:..|      ..||::...::..||   .:...:..||..|:||.|.....|...|
Mouse   361 PKLARATVRDPKTGVLTVASYRVSKSSWLEEDDD---PVVARVNRRMQHITGLTVKTAELLQVAN 422

  Fly   396 YGLGGYFQEHSDYMDIKLYPELTEEGDRL----------------------MTFLFYMTDVPVGG 438
            ||:||.::.|.|:........|..||:||                      .|||.||:||..||
Mouse   423 YGMGGQYEPHFDFSRRPFDSGLKTEGNRLATFLNYSDEQDAFKRLGTGNRVATFLNYMSDVEAGG 487

  Fly   439 TTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPC 502
            .|:||....||.||||:|:|||||..:|:.:..||||.||.:||.:||..|......|.|.:||
Mouse   488 ATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	26/135 (19%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	63/192 (33%)
P4ha2	XP_006532515.1	P4Ha_N	28..157	CDD:369820	26/135 (19%)
P4ha2	XP_006532515.1	P4Hc	348..541	CDD:214780	64/195 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920