DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34345 and phy-2

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_502317.1	Gene:	phy-2 / 178170	WormBaseID:	WBGene00004025	Length:	539	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	140/533 - (26%)
Similarity:	234/533 - (43%)	Gaps:	99/533 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 AKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIFINSLTPNYLDHKV 88
            |:|....::.:.|.:...| |.:||...:.|: |.|.:.              .|:.|
Worm    31 AEKDVTTIIDQYIEAERAR-LDDLRRYAHEYV-HRNAHA--------------ESVGP------- 72

  Fly    89 DRYKYVSNPLNSFGLLRRAHQDWPKLIAYLKDQGNIKVDIEEMNKLINRT----------PHAND 143
               ::|:||:|::.|::|...:|.|:       .||.::.:....|.|.|          |...|
Worm    73 ---EFVTNPINAYLLIKRLTTEWKKV-------ENIMLNNKASTFLKNITDNRVRSEVKFPGEED 127

  Fly   144 MEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAEWYRIAL 208
            :..|...:.|::..|.|.:.|::.|::.|:::|:::|..|...:....|.:.::.....|.::||
Worm   128 LSGAATALLRLQDTYSLDTLDLSNGIIGGEKVSNKLSGHDTFEVGRSAYNQKDYYHCLMWMQVAL 192

  Fly   209 SVFTKPKNNIAFKFYAPKRKELE--KMFVISRLQEGSVENLTDCLKELSQ-DPNNSLVHLRPRKS 270
               .|.:|.     ..|..:|.|  :....|..|:|:|.......|.|:: .||    |.|.:.:
Worm   193 ---VKIENE-----NPPTIEEWEILEYLAYSLYQQGNVRRALSLTKRLAKIAPN----HPRAKGN 245

  Fly   271 PTMIEQGCQGK-----FPP---------------GPQLVCR----------------YNSTTTPF 299
            ....|...|||     .||               ..:.:||                |.....||
Worm   246 VKWYEDMLQGKDMVGDLPPIVNKRVEYDGIVERDAYEALCRGEIPPVEPKWKNKLRCYLKRDKPF 310

  Fly   300 MRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTREEMILGTTTNYTTPDRVNRLFHIKVTDD 364
            :::||:|.|.:..|||..|:.:||:||||..:..:...::...|..|..|.:..:..:.|..:..
Worm   311 LKLAPIKVEILRFDPLAVLFKNVIHDSEIEVIKELASPKLKRATVQNSKTGELEHATYRISKSAW 375

  Fly   365 DGGKLDKTL--VN-RMADISGLDVGNTTTLARINYGLGGYFQEHSDY--MDIKLYPELTEEGDRL 424
            ..|.||..:  || |:.|.:.|:...:..|...||||||::..|.|:  .:.|...:....|:|:
Worm   376 LKGDLDPVIDRVNRRIEDFTNLNQATSEELQVANYGLGGHYDPHFDFARKEEKNAFKTLNTGNRI 440

  Fly   425 MTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAVCPTIVGSRWVLVK 489
            .|.||||:....||.|:|.....|:.|.|..|||||||..:|:.:|.||||.||.::|.:||..|
Worm   441 ATVLFYMSQPERGGATVFNHLGTAVFPSKNDALFWYNLRRDGEGDLRTRHAACPVLLGVKWVSNK 505

  Fly   490 SMLNYEQMFKKPC 502
            .:....|.|.:||
Worm   506 WIHEKGQEFTRPC 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	30/139 (22%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	58/169 (34%)
phy-2	NP_502317.1	P4Ha_N	21..154	CDD:285528	33/155 (21%)
		TPR_16	169..240	CDD:290168	17/82 (21%)
		P4Hc	335..508	CDD:214780	59/172 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920