DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34345 and p4ha1

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_031761963.1	Gene:	p4ha1 / 100490484	XenbaseID:	XB-GENE-987760	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	552	Identity:	150/552 - (27%)
Similarity:	252/552 - (45%)	Gaps:	104/552 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIFINSL 79
            ||.||:...|.           :..||..:.:|...|...:..|.:|:...:||:..::.:.:.
Frog     9 LLGLFSCAHAD-----------FFTSIGHMIDLLNTEKDLVTSLKDYIKAEEQKLAQIKKWADK- 61

  Fly    80 TPNYLDHKVDRYK-----YVSNPLNSFGLLRRAHQDWPKLIAYLKDQGNIKVDIEE---MNKLIN 136
                |||..|...     |:.:|:|:|.|::|.:.:|.||      :..|..||.:   .|..|.
Frog    62 ----LDHLTDTATKDPEGYLGHPVNAFKLMKRLNTEWVKL------ENLILKDISDGFISNLTIQ 116

  Fly   137 RT--PHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRR 199
            |.  |:..|...|...:.|::..|:|.:..:::|.:.|.:..:.::|.||..|....|..:::..
Frog   117 RQYFPNDEDQTGAAKALLRLQDTYNLDTDTISKGNLPGVKHKTSLTAEDCFDLGKTAYTDADYYH 181

  Fly   200 AAEWYRIALSVFTKPKNNIAFKFYAPKRKELEKMFVISRL-----QEGSVEN-LTDCLKELSQDP 258
            ...|...|||           :..|.:...|:|:.|:..|     |:|.::. ||...:.|..||
Frog   182 TELWMEQALS-----------QLDAGEESSLDKVMVLDYLSYAVYQQGDLDKALTLTKRSLELDP 235

  Fly   259 -----NNSLVH------------------LRPRK-------SPTMIEQGCQGKFPPG-------- 285
                 |.:|.|                  ||.||       .....|:.|:|:   |
Frog   236 EHQRGNGNLRHIMSKESNKSSSSPSEGAELRTRKGRPKDHLEKEKYEKLCRGE---GVKMTSRRQ 297

  Fly   286 PQLVCRY-NSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTREEMILGTTTN--- 346
            .:|.||| :....|.:.::|.|:|:....|.|..|||:|.|.||:::..:.:..:...|.:|
Frog   298 KRLFCRYFDGKKDPLLILSPTKQEDEWDKPRIVRYHDIISDEEISKVKELAKPRLRRATISNPIT 362

  Fly   347 ---YTTPDRVNRLFHIKVTDDDGGKLDKTLVNRMADISGLDVGNTTTLARINYGLGGYFQEHSDY 408
               .|...|:.:...:...:|   .:...|..|:..::|||:.....|...|||:||.::.|.|:
Frog   363 GVLETAQYRITKSAWLSGYED---PVVARLNRRIEGVTGLDMSTAEELQVANYGIGGQYEPHFDF 424

  Fly   409 MDIKLYPELTEE---GDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNL 470
            :. |..|:..::   |:|:.|:||||:||..||.|:||....|:.||||:|:|||||..:|:.:.
Frog   425 LR-KYEPDAFKKLGTGNRVATWLFYMSDVEAGGATVFPEVGAAVYPKKGTAVFWYNLLESGEGDY 488

  Fly   471 LTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPC 502
            .||||.||.:||::||..|.:....|.|::||
Frog   489 STRHAACPVLVGNKWVSNKWIHERGQEFRRPC 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	34/139 (24%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	59/173 (34%)
p4ha1	XP_031761963.1	P4Ha_N	24..111	CDD:400573	23/97 (24%)
p4ha1	XP_031761963.1	P4Hc	337..510	CDD:214780	60/176 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110