DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34345 and p4ha1b

DIOPT Version :9

Sequence 1:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_999856.1	Gene:	p4ha1b / 100003675	ZFINID:	ZDB-GENE-030131-4089	Length:	536	Species:	Danio rerio

Alignment Length:	565	Identity:	156/565 - (27%)
Similarity:	259/565 - (45%)	Gaps:	106/565 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILLNWILL-FLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTL 72
            ::|.|.|| |||...   .|.||      :..|...:::|...|...:..|..|:...:.:::.:
Zfish     1 MMLAWFLLSFLFHFL---YAHND------FFTSTGQMTDLLYAEKDLVTSLKEYIKQEENRLEQV 56

  Fly    73 RIFINSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKL-IAYLKDQGNIKVDIEEMNKLIN 136
            :.:.:.|....:....|...::.:|:|:|.|::|.:.:|..| ...|||..|..:.    |..:.
Zfish    57 KEWADKLDSLTITATQDPEGFLGHPVNAFKLMKRLNSEWSDLENLVLKDTTNGFIS----NLTVQ 117

  Fly   137 RT--PHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLAL-------ADY-- 190
            |.  |...|...|...:.|::..|.|.::.::.|.:.|....|||:..||..|       |||
Zfish   118 RQYFPTDEDQTGAAKALLRLQDTYQLSANAISSGDLPGVVHKSRMTVEDCYELGKIAYSDADYYH 182

  Fly   191 --------------------------------MYKRSEFRRAAEWYRIALSVFTKPKNNIA---- 219
                                            :|::.|..||.|..:..|.:  .|.::.|
Zfish   183 TELWMAQALSQLDEGEESPIDKVTVMDYLSYAIYQQGELDRALELTKRMLKL--DPNHHRANGNL 245

  Fly   220 --FKFYAPKRKELEKMFVISRLQEGS--VENLTDCLKELSQDPNNSLVHLRPRKSPTMIEQGCQG 280
              |:|...|:::.|.    .:.:|..  |.:..|..::.|:||      |..||.   .|:.|:|
Zfish   246 KYFEFQLEKQRKAEN----EKKEEDQKRVLDKRDAQRKRSKDP------LPERKK---YERLCRG 297

  Fly   281 ---KFPPGPQ--LVCRY-NSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTREEM 339
               |..|..|  |.||| |:...|.:.:||:|:|:....|.|..||::|.||||..:..:.:..:
Zfish   298 EGIKLTPRRQSRLFCRYSNNNRNPRLLLAPVKQEDEWDRPRIVRYHEIISDSEIETVKEMAKPRL 362

  Fly   340 ILGTTTN------YTTPDRVNRLFHIKVTDDDGGKLDKTL--VN-RMADISGLDVGNTTTLARIN 395
            ...|.:|      .|.|.|:::...:      .|....|:  :| |:.|::||::.....|...|
Zfish   363 RRATISNPITGVLETAPYRISKSAWL------SGYEHSTIERINQRIEDVTGLEMDTAEELQVAN 421

  Fly   396 YGLGGYFQEHSDYMDIKLYPELTEE---GDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSAL 457
            ||:||.::.|.|: ..|..|:..:|   |:|:.|:||||:||..||.|:|.....|:.||||:|:
Zfish   422 YGVGGQYEPHFDF-GRKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFTDVGAAVWPKKGTAV 485

  Fly   458 FWYNLHNNGDPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPC 502
            |||||..:|:.:..||||.||.:||::||..|.:....|.|::||
Zfish   486 FWYNLFPSGEGDYSTRHAACPVLVGNKWVSNKWIHERGQEFRRPC 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	27/132 (20%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	62/176 (35%)
p4ha1b	NP_999856.1	P4Ha_N	24..153	CDD:285528	27/132 (20%)
		TPR repeat	164..199	CDD:276809	6/34 (18%)
		TPR_16	168..238	CDD:290168	11/71 (15%)
		TPR repeat	204..234	CDD:276809	6/29 (21%)
		P4Hc	347..520	CDD:214780	63/179 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920