DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34384 and DGKD

DIOPT Version :9

Sequence 1:	NP_001246971.1	Gene:	CG34384 / 5740362	FlyBaseID:	FBgn0085413	Length:	1936	Species:	Drosophila melanogaster
Sequence 2:	XP_011510330.1	Gene:	DGKD / 8527	HGNCID:	2851	Length:	1238	Species:	Homo sapiens

Alignment Length:	1987	Identity:	629/1987 - (31%)
Similarity:	821/1987 - (41%)	Gaps:	815/1987 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAHLKLDTLHVQRSPRGSRRSSPSSGRSSACSSGSISPVPIIPIISISHDGDESESESEIET--E 63
            :.|.||.:..|..:..|:.:     |.|..|.    ..||::|    .:.|....:.|...|  |
Human    10 VTHQKLGSQGVHLAVAGALQ-----GHSCCCG----CTVPLLP----GNPGLAGVTSSTTWTGAE 61

  Fly    64 PARLFQRRMSTKCTNNLAAIIKEGFLLKHTWSFQRWRRRYFRLKRNMLFYAKDEKCDVFDDIDLS 128
            ..|:..|   |........|||||.|.|...||||.:||||:|:...|:|||..|..:||::||:
Human    62 GQRMDLR---TSWPRTRTTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLT 123

  Fly   129 DLCYFECGIKNVNHSFQIITPTRSLVLCAESRREMEDWLGSLKTATAPQRPRGDSFLIEQH--DI 191
            |....|...||||:||.:|||.|.|:|||::|:|||||:.:|||.     ...:.|...|:  |.
Human   124 DASVAESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTV-----QNREHFEPTQYSMDH 183

  Fly   192 LSNHHHWYATSHARPTYCNVCRDALSGVTSHGLSCEVCKCKVHKRCAAKSIANCKWTTLASVGKD 256
            .|..|:|||.||||||||||||:||||||||||||||||.|.|||||.::..|||||||||:|||
Human   184 FSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKD 248

  Fly   257 IIEQADGIIMPHQWMEGNLPVSSMCAVCKKTCGSVLRLQDWRCLWCRATVHVACRPQMAVACPIG 321
            |||.||||.|||||:|||||||:.|.||.|||||||||||||||||:|.||.:|:..:...||:|
Human   249 IIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLG 313

  Fly   322 PAKLSVVPPTSVHSISTDDAWDVASPKGNFSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDL 386
            ..|:||:|||:::||.:|..|..:.|....|||||||||||||||||||||||||||||||||||
Human   314 LCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDL 378

  Fly   387 ISTGPSLGLRLFRHFEMFRILVCSGDGSVGWVLSEIDRFNMHKQCQVAVMPLGTGNDLARVLGWG 451
            ::.||.||||||:.|:.||||||.|||||||||||||..|:|||||:.|:|||||||||||||||
Human   379 MNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWG 443

  Fly   452 SSCDDDTHLPQILERYESASTKMLDRWSIMVFEKAIP-----VPKTPKMSISTEQEAMLTGMVTS 511
            |:|||||.||||||:.|.||||||||||:|.:|..:|     ...|...|..:|.:.:|. ...|
Human   444 SACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSEDSEVQQILF-YEDS 507

  Fly   512 ANHHLRFIVETNDTQTLIRSTRNLCDTVDDLVCRI-------SEHHKDDEQLAVKCDILRQKLNM 569
            ...||..|:.::....:|.|.:.||:||.|.|.|:       :|..::.|.:|.||.:|::||:.
Human   508 VAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCSVLKEKLDS 572

  Fly   570 LLDALQEE------------------EIGAHSGDDLIATIRSLIARSIPVTPGSNAYLLNPNISI 616
            ||..|.:|                  |.|..||....:|...|:|.:.|..|    .:..|
Human   573 LLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARP----QIFRP---- 629

  Fly   617 EKTEKDQINTKERRNSRSLRSSEKEALQCRANSVKRAIYNVVEHSEPGRPKRYQRKLSITPFEAL 681
                                   :|.|..||||:|:||..::||:|
Human   630 -----------------------REQLMLRANSLKKAIRQIIEHTE------------------- 652

  Fly   682 KLPTASGESTPCTSPLPIIPPINIISPTMETSRLTCISPLPDTRRDSVDENFFNSINLPAPRQFA 746
                                                         .:|||            |.|
Human   653 ---------------------------------------------KAVDE------------QNA 660

  Fly   747 DSRRSSG-VEVIQEIEEGANGETVYRKSRMSLTGGANIDDAGNRLSPCSDAGENTPTERKVDFLR 810
            .::...| |..:.|.||..:                      :|:.|        |......|
Human   661 QTQEQEGFVLGLSESEEKMD----------------------HRVCP--------PLSHSESF-- 693

  Fly   811 VPIHTGEPIVDPLCDYRPHEVFERTYYMTREMDKGKEKDKEKDKPVEIDKEKDTCVEKEGSMPAE 875
                 |.|                         ||:.:.|               |.|.   |.|
Human   694 -----GVP-------------------------KGRSQRK---------------VSKS---PCE 710

  Fly   876 KLVHTCNLQVPGVVVTPNPQNVYSSASITIIDTDAQTTTEQSSSDDLGGEASDVLSAISNEECSV 940
            ||:...:|            ::.||||:
Human   711 KLISKGSL------------SLGSSASL------------------------------------- 726

  Fly   941 ASEIFDKQDAGQTVGDIIQNMDASNFTHIDSPETSDETEAMPGESIMDDISSVLGHDITYALQDN 1005

Human   727 ----------------------------------------------------------------- 726

  Fly  1006 TLTDDTTTLCSEHAGPPKPPRKKSLSALSRTQAHPRRRNSSPPRMARLARMDSDDNPQQFGFENI 1070
                           ||:|..:..|.||
Human   727 ---------------PPQPGSRDGLPAL------------------------------------- 739

  Fly  1071 VFEIDNRCDDQKMREPPRYCSLAQFVEGNDIARQSFKQLMLEQHRGGDNDSDYPEHEQTPTNKGA 1135

Human   740 ----------------------------------------------------------------- 739

  Fly  1136 NLLATTSEDELSTQTAIKIEIQDIDATVRNLNSSMKPNTILTTSTSPTKKSGHGQDVKRITFDES 1200
                                                 ||.:.
Human   740 -------------------------------------NTKIL----------------------- 744

  Fly  1201 CKKESFDDVNPNYPQISVVVRPPTPLRGDCIKPTVSLLPVSSGGAMTVSMTCSGMLGVRAMNASE 1265
                        ||.:.                                   :||.|
Human   745 ------------YPNVR-----------------------------------AGMSG-------- 754

  Fly  1266 IRRHSSHAPGLAVREFDKDKDRRHSGFNPNQLTLDPEHARFLSSSPAASRRISCGSLFKKKNKKI 1330

Human   755 ----------------------------------------------------------------- 754

  Fly  1331 GTKRSYGLFSVRFFVVAEPDFRLATLALIRPLIPLPNEALPNLQTLKGSKSSLFMGSTLFGFDHL 1395
                                                  :||
Human   755 --------------------------------------SLP------------------------ 757

  Fly  1396 ASAEKDKEEKSGKDKEKTPTDETNRKLPIINPLVRLPNWPNLANGGGFISKCLLANADTLCAAVS 1460
                                                        ||..||: ||.|||
Human   758 --------------------------------------------GGSVISR-LLINAD------- 770

  Fly  1461 PLMDPDETLLAGYHEKCVMNNYFGIGIDAKISLDFHNKREEHPEKCRSRARNYMWYGVLGSKQLL 1525
            |.....|| |..|.||||||||||||:||||||||:|||:|||||||||.:|.|||||||:|:||
Human   771 PFNSEPET-LEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELL 834

  Fly  1526 QKTCKNLEQRVQLECDGQRIPLPELQGIVILNIPSFMGGTNFWGSSKKDDIFLPPSFDDRVLEVV 1590
            .:|.|||||:|.|||||:.||||.||||.:|||||:.|||||||.:|:||.|..|||||::||||
Human   835 HRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVV 899

  Fly  1591 AVFGSVQMAASRLINLQHHRIAQCQSVQINILGDEEIPIQVDGEAWLQPPGMIRILHKNRVQMLC 1655
            |||||:|||.||:|.|||||||||::|:|:|||||.:|:|||||||:||||.|||:||||.|.|.
Human   900 AVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLT 964

  Fly  1656 RNRSLELSLKSWQEKQRQHSISIQRDASSTASEHANSTDEVISERECYVLLNFIEAVSSLVKWVK 1720
            |:|:.|.:||||::||:   ..:.|..|  .|.|    .|::||.|...:..|.:|...|:..::
Human   965 RDRAFESTLKSWEDKQK---CELPRPPS--CSLH----PEMLSEEEATQMDQFGQAAGVLIHSIR 1020

  Fly  1721 FLIISHPALQHDLYEVACRASEALESIHPQGKLLEGPSLRTKLVEVIDSSRQLYDDACTLLRDRG 1785
            .:..||..::.:|......:|::::.::.:.:..||.:. :.::|::::.|.|..:...||..:
Human  1021 EIAQSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNC-SFVLEMVNNFRALRSETELLLSGK- 1083

  Fly  1786 HSLILREDLETKLSAALANMEMELKKCS-----VQKCIDGKLRAYFNVLAPNEES---DGRRKSR 1842
            .:|.|....:.:|.:|||.|:.:|::.:     .|....|           :|||   |..::|
Human  1084 MALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPG-----------DEESVMLDLAKRS- 1136

  Fly  1843 PFWVRLRSGSTAGQQAFKPPLTNTREAANN--------WSVNEVVTWLETMQLSEYVDSFLKNDI 1899
                  |||.......||....|..:.|::        |...||..|||.:.|.||.|.|.::||
Human  1137 ------RSGKFRLVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDI 1195

  Fly  1900 RGKELLTLGRRDLKDLGVVKVGHVKRILQAIKDLSEN 1936
            ||.|||.|.|||||||||.||||:||||..||:||.:
Human  1196 RGSELLHLERRDLKDLGVTKVGHMKRILCGIKELSRS 1232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34384	NP_001246971.1	PH	83..175	CDD:278594	50/91 (55%)
		PH_DGK_type2	84..180	CDD:270093	49/95 (52%)
		C1	196..245	CDD:197519	38/48 (79%)
		C1	268..318	CDD:197519	34/49 (69%)
		DAGKc	355..477	CDD:214487	101/121 (83%)
		DAGK_acc	1478..1635	CDD:279003	117/156 (75%)
		SAM_DGK-delta-eta	1869..1933	CDD:188906	39/71 (55%)
		SAM	1872..1935	CDD:197735	39/70 (56%)
DGKD	XP_011510330.1	PH	78..166	CDD:278594	47/87 (54%)
		PH_DGK_type2	79..175	CDD:270093	49/100 (49%)
		C1	188..237	CDD:237996	38/48 (79%)
		C1	260..310	CDD:237996	34/49 (69%)
		DAGKc	347..469	CDD:214487	101/121 (83%)
		DAGKa	787..944	CDD:214486	117/156 (75%)
		SAM_DGK-delta	1165..1229	CDD:188974	38/63 (60%)
		SAM	1166..1229	CDD:197735	38/62 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155646
Domainoid	1	1.000	260	1.000	Domainoid score	I1984
eggNOG	1	0.900	-	-		E1_KOG1170
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1050	1.000	Inparanoid score	I260
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29151at33208
OrthoFinder	1	1.000	-	-		FOG0002628
OrthoInspector	1	1.000	-	-		otm40760
orthoMCL	1	0.900	-	-		OOG6_102702
Panther	1	1.100	-	-	O	PTHR11255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3373
SonicParanoid	1	1.000	-	-		X741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790