Protein Alignment CG34384 and Dgkh

DIOPT Version :10

• Sequence 1: NP_001246971.1
• Gene: CG34384 / 5740362
• FlyBaseID: FBgn0085413
• Length: 1936
• Species: Drosophila melanogaster
• Sequence 2: XP_036014587.1
• Gene: Dgkh / 380921
• MGIID: 2444188
• Length: 1246
• Species: Mus musculus
• Alignment Length: 1971
• Identity: 622/1971 - (31%)
• Similarity: 809/1971 - (41%)
• Gaps: 809/1971 - (41%)

  Fly    17 GSRRSSPSSGRSSACSSGSISPVPIIPIISISHDGDESESESEIETEPARLFQRRMSTKCTNNLA 81
            ||:.........:...:.::||....|       |::| |:||.|.|..:...|::||.......
Mouse    29 GSQHHPQGVAGGAVAGASAVSPTAAGP-------GEDS-SDSEAEQEGPQKLIRKVSTSGQMRTK 85

  Fly    82 AIIKEGFLLKHTWSFQRWRRRYFRLKRNMLFYAKDEKCDVFDDIDLSDLCYFECGIKNVNHSFQI 146
            ..||||.|||.|.|||||::|||:|:...|:||||.|..:||::||||....|...||.|:||.|
Mouse    86 TSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTI 150

  Fly   147 ITPTRSLVLCAESRREMEDWLGSLKTATAPQRPRGDSFLIEQHDILSNHHHWYATSHARPTYCNV 211
            |||.|.|:||||:|:|||.|:.|||:..:.:......|.:|.   .|..|:|||.||||||:|||
Mouse   151 ITPFRRLMLCAENRKEMEVWISSLKSVQSREPYEVAQFNVEH---FSGMHNWYACSHARPTFCNV 212

  Fly   212 CRDALSGVTSHGLSCEVCKCKVHKRCAAKSIANCKWTTLASVGKDIIEQADGIIMPHQWMEGNLP 276
            ||::|||||||||||||||.|.|||||.::..|||||||||:||||||..||:.|||||:|||||
Mouse   213 CRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLP 277

  Fly   277 VSSMCAVCKKTCGSVLRLQDWRCLWCRATVHVACRPQMAVACPIGPAKLSVVPPTSVHSISTD-D 340
            ||:.||||.||||||||||||:||||:..||.||:......||:|..|:|::||.:::  ||| |
Mouse   278 VSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDVYHPVCPLGQCKVSIIPPIALN--STDSD 340

  Fly   341 AWDVASPKGNFSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLISTGPSLGLRLFRHFEMFR 405
            .:..|:.....|||||||||||||||||||||||||||||||||||::.||.||||||:.|:.||
Mouse   341 GFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPYLGLRLFQKFDNFR 405

  Fly   406 ILVCSGDGSVGWVLSEIDRFNMHKQCQVAVMPLGTGNDLARVLGWGSSCDDDTHLPQILERYESA 470
            ||||.|||||||||||||:.|:|||||:.|:|||||||||||||||.|.||||.||||||:.|.|
Mouse   406 ILVCGGDGSVGWVLSEIDKLNLHKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERA 470

  Fly   471 STKMLDRWSIMVFEKAIPVPKT--PKMSISTEQEAMLTGMVTSANHHLRFIVETNDTQTLIRSTR 533
            |||||||||||.:|..:|...:  |:...:|| |..:|....|..:||..||.:::...:|.|.:
Mouse   471 STKMLDRWSIMTYELKLPAKSSLLPEPVAATE-EFYMTIYEDSVANHLTKIVNSDEHAVVISSAK 534

  Fly   534 NLCDTVDDLVCRIS-------EHHKDDEQLAVKCDILRQKLNMLLDALQEEEIGAHSGDDLIATI 591
            .||:||.|.|.::.       |:....|.:|.||.:|.:||..||.||..:
Mouse   535 ILCETVKDFVAKVEKAQDRTLENTVVAEAVASKCSVLNEKLEQLLQALHAD-------------- 585

  Fly   592 RSLIARSIPVTPGSNAYLLNPNISIEKT-----------EKDQINTKERRNSRSLRSSEKEALQC 645
                :::..|.||     :.|.|..|.|           .|||: ..:.....|.::.:...:..
Mouse   586 ----SQASRVPPG-----IGPAIPEEDTVESASDESLGESKDQL-VNDIGKPSSQKAVKPREIML 640

  Fly   646 RANSVKRAIYNVVEHSEPGRPKRYQRKLSITPFEALKLPTASGESTPCTSPLPIIPPINIISPTM 710
            ||||:|:|:..|:|.:|
Mouse   641 RANSLKKAVRQVIEEAE------------------------------------------------ 657

  Fly   711 ETSRLTCISPLPDTRRDSVDENFFNSINLPAPRQFADSRRSSGVEVIQEIEEGANGETVYRKSRM 775
                            ..:||        ||
Mouse   658 ----------------KVMDE--------PA---------------------------------- 664

  Fly   776 SLTGGANIDDAGNRLSPCSDAGENTPTERKVDFLRVPIHTGEPIVDPLCDYRPHEVFERTYYMTR 840
                                                 :...|| |.|.|||
Mouse   665 -------------------------------------VQPSEP-VSPSCDY-------------- 677

  Fly   841 EMDKGKEKDKEKDKPVEIDKEKDTCVEKEGSMPAEKLVHTCNLQVPGVVVTPNPQNVYSSASITI 905
                                                                             
Mouse   678 ----------------------------------------------------------------- 677

  Fly   906 IDTDAQTTTEQSSSDDLGGEASDVLSAISNEECSVASEIFDKQDAGQTVGDIIQNMDASNFTHID 970
                 .|.|:::..||
Mouse   678 -----DTETDEAKEDD------------------------------------------------- 688

  Fly   971 SPETSDETEAMPGESIMDDISSVLGHDITYALQDNTLTDDTTTLCSEHAGPPKPPRKKSLSALSR 1035
                                                                   .|:||||.:.
Mouse   689 -------------------------------------------------------AKESLSAKTT 698

  Fly  1036 TQAHPRRRNSSPPRMARLARMDSDDNPQQFGFENIVFEIDNRCDDQKMREPPRYCSLAQFVEGND 1100
            :|        ||...|.                                     |.
Mouse   699 SQ--------SPDAQAS-------------------------------------CG--------- 709

  Fly  1101 IARQSFKQLMLEQHRGGDNDSDYPEHEQTPTNKGANLLATTSEDELSTQTAIKIEIQDIDATVRN 1165
                                     |.||.:..|. .:|||.|:
Mouse   710 -------------------------HPQTDSVAGP-AMATTKEN--------------------- 727

  Fly  1166 LNSSMKPNTILTTSTSPTKKSGHGQDVKRITFDESCKKESFDDVNPNYPQISVVVRPPTPLRGDC 1230
                                                                             
Mouse   728 ----------------------------------------------------------------- 727

  Fly  1231 IKPTVSLLPVSSGGAMTVSMTCSGMLGVRAMNASEIRRHSSHAPGLAVREFDKDKDRRHSGFNPN 1295
                   |||     :...:.|.|:   ||              |||
Mouse   728 -------LPV-----LNTRIICPGL---RA--------------GLA------------------ 745

  Fly  1296 QLTLDPEHARFLSSSPAASRRISCGSLFKKKNKKIGTKRSYGLFSVRFFVVAEPDFRLATLALIR 1360
                                                                      |::|
Mouse   746 ----------------------------------------------------------ASIA--- 749

  Fly  1361 PLIPLPNEALPNLQTLKGSKSSLFMGSTLFGFDHLASAEKDKEEKSGKDKEKTPTDETNRKLPII 1425
                                                                             
Mouse   750 ----------------------------------------------------------------- 749

  Fly  1426 NPLVRLPNWPNLANGGGFISKCLLANADTLCAAVSPLMDPDETLLAGYHEKCVMNNYFGIGIDAK 1490
                          |...|:|.||||.|...|  :|.:|||...|.||.||||||||||||:|||
Mouse   750 --------------GSSIINKMLLANIDPFGA--TPFIDPDLDSLDGYSEKCVMNNYFGIGLDAK 798

  Fly  1491 ISLDFHNKREEHPEKCRSRARNYMWYGVLGSKQLLQKTCKNLEQRVQLE-----------CDGQR 1544
            |||:|:|||||||||||||.:|.|||||||:::|||::.||||||||||           ||||.
Mouse   799 ISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLEGISFLSSFCDQCDGQY 863

  Fly  1545 IPLPELQGIVILNIPSFMGGTNFWGSSKKDDIFLPPSFDDRVLEVVAVFGSVQMAASRLINLQHH 1609
            ||||.||||.:|||||:.|||||||.:|:||||..|||||::|||||||.|||||.||:|.||||
Mouse   864 IPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAVFDSVQMAVSRVIKLQHH 928

  Fly  1610 RIAQCQSVQINILGDEEIPIQVDGEAWLQPPGMIRILHKNRVQMLCRNRSLELSLKSWQEKQRQH 1674
            |||||::|:|.|.|||.:|:|||||||:||||:|:|:||||.|||.|:|:.|.:||||::||:..
Mouse   929 RIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCD 993

  Fly  1675 S----------ISIQRDASSTASEHANSTDEVISERECYVLLNFIEAVSSLVKWVKFLIISHPAL 1729
            |          |....|.         :|:||...|.|      .:|...|:..:......|..|
Mouse   994 SGKPVLRTNLYIHPAPDL---------ATEEVSQMRLC------SQAAEELITRICDAATIHCLL 1043

  Fly  1730 QHDLYEVACRASEALESIHPQGKLLEGPSLRTKLVEVIDSSRQLYDDACTLLRDRGHSLILREDL 1794
            :.:|.......|.||...:|:   ......|....|:..:.:.||::...||..| ..|.|....
Mouse  1044 EQELAHAVNACSHALNKANPR---FPESLTRDTATEIAINVKALYNETEALLVGR-VPLHLESPH 1104

  Fly  1795 ETKLSAALANMEMELKKCSVQKCIDGKLRAYFNVLAPNEESD-------GRRKSRPFWV--RLRS 1850
            |.::|:||.::||||:|.:       ::...:.:|.|:|:.:       ...||..|.:  :.:.
Mouse  1105 EERVSSALHSVEMELQKLT-------EIPWLYYILRPSEDEEPPLDCTKRNNKSTVFRIVPKFKK 1162

  Fly  1851 GSTAGQQAFKPPLTNTREAANNWSVNEVVTWLETMQLSEYVDSFLKNDIRGKELLTLGRRDLKDL 1915
            .....|:....|:       .||...||..||:.:.|.||.:.|:::|:||.|||.|.|||||||
Mouse  1163 EKAQKQKTSSQPV-------QNWGTEEVAAWLDLLNLGEYKEIFIRHDVRGAELLHLERRDLKDL 1220

  Fly  1916 GVVKVGHVKRILQAIKDLSEN 1936
            |:.||||:|||||.||:|..|
Mouse  1221 GIPKVGHMKRILQGIKELERN 1241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34384	NP_001246971.1	PH_DGK_type2	84..180	CDD:270093	53/95 (56%)
		C1_DGK_typeII_rpt1	192..251	CDD:410350	43/58 (74%)
		C1_DGK_typeII_rpt2	268..321	CDD:410402	36/52 (69%)
		DAGKc	355..477	CDD:214487	100/121 (83%)
		DAGKa	1478..1635	CDD:214486	119/167 (71%)
		SAM_DGK-delta-eta	1869..1933	CDD:188906	36/63 (57%)
Dgkh	XP_036014587.1	PH_DGK_type2	88..184	CDD:270093	53/95 (56%)
		C1_DGKeta_rpt1	168..253	CDD:410398	51/87 (59%)
		C1_DGKeta_rpt2	264..325	CDD:410444	40/60 (67%)
		DAGKc	355..477	CDD:214487	100/121 (83%)
		DAGKa	786..954	CDD:214486	119/167 (71%)
		SAM_DGK-eta	1174..1238	CDD:188975	37/70 (53%)