DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34384 and Dgkh

DIOPT Version :9

Sequence 1:	NP_001246971.1	Gene:	CG34384 / 5740362	FlyBaseID:	FBgn0085413	Length:	1936	Species:	Drosophila melanogaster
Sequence 2:	XP_036014587.1	Gene:	Dgkh / 380921	MGIID:	2444188	Length:	1246	Species:	Mus musculus

Alignment Length:	1971	Identity:	622/1971 - (31%)
Similarity:	809/1971 - (41%)	Gaps:	809/1971 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GSRRSSPSSGRSSACSSGSISPVPIIPIISISHDGDESESESEIETEPARLFQRRMSTKCTNNLA 81
            ||:.........:...:.::||....|       |::| |:||.|.|..:...|::||.......
Mouse    29 GSQHHPQGVAGGAVAGASAVSPTAAGP-------GEDS-SDSEAEQEGPQKLIRKVSTSGQMRTK 85

  Fly    82 AIIKEGFLLKHTWSFQRWRRRYFRLKRNMLFYAKDEKCDVFDDIDLSDLCYFECGIKNVNHSFQI 146
            ..||||.|||.|.|||||::|||:|:...|:||||.|..:||::||||....|...||.|:||.|
Mouse    86 TSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTI 150

  Fly   147 ITPTRSLVLCAESRREMEDWLGSLKTATAPQRPRGDSFLIEQHDILSNHHHWYATSHARPTYCNV 211
            |||.|.|:||||:|:|||.|:.|||:..:.:......|.:|.   .|..|:|||.||||||:|||
Mouse   151 ITPFRRLMLCAENRKEMEVWISSLKSVQSREPYEVAQFNVEH---FSGMHNWYACSHARPTFCNV 212

  Fly   212 CRDALSGVTSHGLSCEVCKCKVHKRCAAKSIANCKWTTLASVGKDIIEQADGIIMPHQWMEGNLP 276
            ||::|||||||||||||||.|.|||||.::..|||||||||:||||||..||:.|||||:|||||
Mouse   213 CRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLP 277

  Fly   277 VSSMCAVCKKTCGSVLRLQDWRCLWCRATVHVACRPQMAVACPIGPAKLSVVPPTSVHSISTD-D 340
            ||:.||||.||||||||||||:||||:..||.||:......||:|..|:|::||.:::  ||| |
Mouse   278 VSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDVYHPVCPLGQCKVSIIPPIALN--STDSD 340

  Fly   341 AWDVASPKGNFSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLISTGPSLGLRLFRHFEMFR 405
            .:..|:.....|||||||||||||||||||||||||||||||||||::.||.||||||:.|:.||
Mouse   341 GFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPYLGLRLFQKFDNFR 405

  Fly   406 ILVCSGDGSVGWVLSEIDRFNMHKQCQVAVMPLGTGNDLARVLGWGSSCDDDTHLPQILERYESA 470
            ||||.|||||||||||||:.|:|||||:.|:|||||||||||||||.|.||||.||||||:.|.|
Mouse   406 ILVCGGDGSVGWVLSEIDKLNLHKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERA 470

  Fly   471 STKMLDRWSIMVFEKAIPVPKT--PKMSISTEQEAMLTGMVTSANHHLRFIVETNDTQTLIRSTR 533
            |||||||||||.:|..:|...:  |:...:|| |..:|....|..:||..||.:::...:|.|.:
Mouse   471 STKMLDRWSIMTYELKLPAKSSLLPEPVAATE-EFYMTIYEDSVANHLTKIVNSDEHAVVISSAK 534

  Fly   534 NLCDTVDDLVCRIS-------EHHKDDEQLAVKCDILRQKLNMLLDALQEEEIGAHSGDDLIATI 591
            .||:||.|.|.::.       |:....|.:|.||.:|.:||..||.||..:
Mouse   535 ILCETVKDFVAKVEKAQDRTLENTVVAEAVASKCSVLNEKLEQLLQALHAD-------------- 585

  Fly   592 RSLIARSIPVTPGSNAYLLNPNISIEKT-----------EKDQINTKERRNSRSLRSSEKEALQC 645
                :::..|.||     :.|.|..|.|           .|||: ..:.....|.::.:...:..
Mouse   586 ----SQASRVPPG-----IGPAIPEEDTVESASDESLGESKDQL-VNDIGKPSSQKAVKPREIML 640

  Fly   646 RANSVKRAIYNVVEHSEPGRPKRYQRKLSITPFEALKLPTASGESTPCTSPLPIIPPINIISPTM 710
            ||||:|:|:..|:|.:|
Mouse   641 RANSLKKAVRQVIEEAE------------------------------------------------ 657

  Fly   711 ETSRLTCISPLPDTRRDSVDENFFNSINLPAPRQFADSRRSSGVEVIQEIEEGANGETVYRKSRM 775
                            ..:||        ||
Mouse   658 ----------------KVMDE--------PA---------------------------------- 664

  Fly   776 SLTGGANIDDAGNRLSPCSDAGENTPTERKVDFLRVPIHTGEPIVDPLCDYRPHEVFERTYYMTR 840
                                                 :...|| |.|.|||
Mouse   665 -------------------------------------VQPSEP-VSPSCDY-------------- 677

  Fly   841 EMDKGKEKDKEKDKPVEIDKEKDTCVEKEGSMPAEKLVHTCNLQVPGVVVTPNPQNVYSSASITI 905

Mouse   678 ----------------------------------------------------------------- 677

  Fly   906 IDTDAQTTTEQSSSDDLGGEASDVLSAISNEECSVASEIFDKQDAGQTVGDIIQNMDASNFTHID 970
                 .|.|:::..||
Mouse   678 -----DTETDEAKEDD------------------------------------------------- 688

  Fly   971 SPETSDETEAMPGESIMDDISSVLGHDITYALQDNTLTDDTTTLCSEHAGPPKPPRKKSLSALSR 1035
                                                                   .|:||||.:.
Mouse   689 -------------------------------------------------------AKESLSAKTT 698

  Fly  1036 TQAHPRRRNSSPPRMARLARMDSDDNPQQFGFENIVFEIDNRCDDQKMREPPRYCSLAQFVEGND 1100
            :|        ||...|.                                     |.
Mouse   699 SQ--------SPDAQAS-------------------------------------CG--------- 709

  Fly  1101 IARQSFKQLMLEQHRGGDNDSDYPEHEQTPTNKGANLLATTSEDELSTQTAIKIEIQDIDATVRN 1165
                                     |.||.:..|. .:|||.|:
Mouse   710 -------------------------HPQTDSVAGP-AMATTKEN--------------------- 727

  Fly  1166 LNSSMKPNTILTTSTSPTKKSGHGQDVKRITFDESCKKESFDDVNPNYPQISVVVRPPTPLRGDC 1230

Mouse   728 ----------------------------------------------------------------- 727

  Fly  1231 IKPTVSLLPVSSGGAMTVSMTCSGMLGVRAMNASEIRRHSSHAPGLAVREFDKDKDRRHSGFNPN 1295
                   |||     :...:.|.|:   ||              |||
Mouse   728 -------LPV-----LNTRIICPGL---RA--------------GLA------------------ 745

  Fly  1296 QLTLDPEHARFLSSSPAASRRISCGSLFKKKNKKIGTKRSYGLFSVRFFVVAEPDFRLATLALIR 1360
                                                                      |::|
Mouse   746 ----------------------------------------------------------ASIA--- 749

  Fly  1361 PLIPLPNEALPNLQTLKGSKSSLFMGSTLFGFDHLASAEKDKEEKSGKDKEKTPTDETNRKLPII 1425

Mouse   750 ----------------------------------------------------------------- 749

  Fly  1426 NPLVRLPNWPNLANGGGFISKCLLANADTLCAAVSPLMDPDETLLAGYHEKCVMNNYFGIGIDAK 1490
                          |...|:|.||||.|...|  :|.:|||...|.||.||||||||||||:|||
Mouse   750 --------------GSSIINKMLLANIDPFGA--TPFIDPDLDSLDGYSEKCVMNNYFGIGLDAK 798

  Fly  1491 ISLDFHNKREEHPEKCRSRARNYMWYGVLGSKQLLQKTCKNLEQRVQLE-----------CDGQR 1544
            |||:|:|||||||||||||.:|.|||||||:::|||::.||||||||||           ||||.
Mouse   799 ISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLEGISFLSSFCDQCDGQY 863

  Fly  1545 IPLPELQGIVILNIPSFMGGTNFWGSSKKDDIFLPPSFDDRVLEVVAVFGSVQMAASRLINLQHH 1609
            ||||.||||.:|||||:.|||||||.:|:||||..|||||::|||||||.|||||.||:|.||||
Mouse   864 IPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAVFDSVQMAVSRVIKLQHH 928

  Fly  1610 RIAQCQSVQINILGDEEIPIQVDGEAWLQPPGMIRILHKNRVQMLCRNRSLELSLKSWQEKQRQH 1674
            |||||::|:|.|.|||.:|:|||||||:||||:|:|:||||.|||.|:|:.|.:||||::||:..
Mouse   929 RIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCD 993

  Fly  1675 S----------ISIQRDASSTASEHANSTDEVISERECYVLLNFIEAVSSLVKWVKFLIISHPAL 1729
            |          |....|.         :|:||...|.|      .:|...|:..:......|..|
Mouse   994 SGKPVLRTNLYIHPAPDL---------ATEEVSQMRLC------SQAAEELITRICDAATIHCLL 1043

  Fly  1730 QHDLYEVACRASEALESIHPQGKLLEGPSLRTKLVEVIDSSRQLYDDACTLLRDRGHSLILREDL 1794
            :.:|.......|.||...:|:   ......|....|:..:.:.||::...||..| ..|.|....
Mouse  1044 EQELAHAVNACSHALNKANPR---FPESLTRDTATEIAINVKALYNETEALLVGR-VPLHLESPH 1104

  Fly  1795 ETKLSAALANMEMELKKCSVQKCIDGKLRAYFNVLAPNEESD-------GRRKSRPFWV--RLRS 1850
            |.::|:||.::||||:|.:       ::...:.:|.|:|:.:       ...||..|.:  :.:.
Mouse  1105 EERVSSALHSVEMELQKLT-------EIPWLYYILRPSEDEEPPLDCTKRNNKSTVFRIVPKFKK 1162

  Fly  1851 GSTAGQQAFKPPLTNTREAANNWSVNEVVTWLETMQLSEYVDSFLKNDIRGKELLTLGRRDLKDL 1915
            .....|:....|:       .||...||..||:.:.|.||.:.|:::|:||.|||.|.|||||||
Mouse  1163 EKAQKQKTSSQPV-------QNWGTEEVAAWLDLLNLGEYKEIFIRHDVRGAELLHLERRDLKDL 1220

  Fly  1916 GVVKVGHVKRILQAIKDLSEN 1936
            |:.||||:|||||.||:|..|
Mouse  1221 GIPKVGHMKRILQGIKELERN 1241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34384	NP_001246971.1	PH	83..175	CDD:278594	53/91 (58%)
		PH_DGK_type2	84..180	CDD:270093	53/95 (56%)
		C1	196..245	CDD:197519	36/48 (75%)
		C1	268..318	CDD:197519	34/49 (69%)
		DAGKc	355..477	CDD:214487	100/121 (83%)
		DAGK_acc	1478..1635	CDD:279003	119/167 (71%)
		SAM_DGK-delta-eta	1869..1933	CDD:188906	36/63 (57%)
		SAM	1872..1935	CDD:197735	37/62 (60%)
Dgkh	XP_036014587.1	PH_DGK_type2	88..184	CDD:270093	53/95 (56%)
		C1_DGKeta_rpt1	168..253	CDD:410398	51/87 (59%)
		C1_DGKeta_rpt2	264..325	CDD:410444	40/60 (67%)
		DAGKc	355..477	CDD:214487	100/121 (83%)
		DAGKa	786..954	CDD:214486	119/167 (71%)
		SAM_DGK-eta	1174..1238	CDD:188975	37/70 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846088
Domainoid	1	1.000	262	1.000	Domainoid score	I1935
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H99373
Inparanoid	1	1.050	1053	1.000	Inparanoid score	I258
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29151at33208
OrthoFinder	1	1.000	-	-		FOG0002628
OrthoInspector	1	1.000	-	-		otm42834
orthoMCL	1	0.900	-	-		OOG6_102702
Panther	1	1.100	-	-	O	PTHR11255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3373
SonicParanoid	1	1.000	-	-		X741
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930