DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34384 and Dgkh

DIOPT Version :9

Sequence 1:	NP_001246971.1	Gene:	CG34384 / 5740362	FlyBaseID:	FBgn0085413	Length:	1936	Species:	Drosophila melanogaster
Sequence 2:	XP_038949964.1	Gene:	Dgkh / 361076	RGDID:	1561955	Length:	1210	Species:	Rattus norvegicus

Alignment Length:	1957	Identity:	629/1957 - (32%)
Similarity:	821/1957 - (41%)	Gaps:	793/1957 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GSRRSSPSSGRSSACSSGSISPVPIIPIISISHDGDESESESEIETEPARLFQRRMSTKCTNNLA 81
            ||:.........:...:|::||....|       |::| |:||.|.|..:...|::||.......
  Rat     5 GSQHHPQGVAGGAVAGAGAVSPTAAGP-------GEDS-SDSEAEQEGPQKLIRKVSTSGQIRTK 61

  Fly    82 AIIKEGFLLKHTWSFQRWRRRYFRLKRNMLFYAKDEKCDVFDDIDLSDLCYFECGIKNVNHSFQI 146
            ..||||.|||.|.|||||::|||:|:...|:||||.|..:||::||||....|...||.|:||.|
  Rat    62 TSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTI 126

  Fly   147 ITPTRSLVLCAESRREMEDWLGSLKTATAPQRPRGDSFLIEQHDILSNHHHWYATSHARPTYCNV 211
            |||.|.|:||||:|:|||||:.|||:..:.:......|.:|.   .|..|:|||.||||||:|||
  Rat   127 ITPFRRLMLCAENRKEMEDWISSLKSVQSREPYEVAQFNVEH---FSGMHNWYACSHARPTFCNV 188

  Fly   212 CRDALSGVTSHGLSCEVCKCKVHKRCAAKSIANCKWTTLASVGKDIIEQADGIIMPHQWMEGNLP 276
            ||::|||||||||||||||.|.|||||.::..|||||||||:||||||..||:.|||||:|||||
  Rat   189 CRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLP 253

  Fly   277 VSSMCAVCKKTCGSVLRLQDWRCLWCRATVHVACRPQMAVACPIGPAKLSVVPPTSVHSISTD-D 340
            ||:.||||.||||||||||||:||||:..||.||:......||:|..|:|::||.:::  ||| |
  Rat   254 VSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDVYHPVCPLGQCKVSIIPPIALN--STDSD 316

  Fly   341 AWDVASPKGNFSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLISTGPSLGLRLFRHFEMFR 405
            .:..|:.....|||||||||||||||||||||||||||||||||||::.||.||||||:.|:.||
  Rat   317 GFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPYLGLRLFQKFDNFR 381

  Fly   406 ILVCSGDGSVGWVLSEIDRFNMHKQCQVAVMPLGTGNDLARVLGWGSSCDDDTHLPQILERYESA 470
            ||||.|||||||||||||:.|:|||||:.|:|||||||||||||||.|.||||.||||||:.|.|
  Rat   382 ILVCGGDGSVGWVLSEIDKLNLHKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERA 446

  Fly   471 STKMLDRWSIMVFEKAIPVPKT--PKMSISTEQEAMLTGMVTSANHHLRFIVETNDTQTLIRSTR 533
            |||||||||||.:|..:|...:  |:.:.:|| |..:|....|..:||..|:.:::...:|.|.:
  Rat   447 STKMLDRWSIMTYELKLPAKASVLPEPAEATE-EFYMTIYEDSVANHLTKILNSDERAVVISSAK 510

  Fly   534 NLCDTVDDLVCRIS-------EHHKDDEQLAVKCDILRQKLNMLLDALQEEEIGAHSGDDLIATI 591
            .||:||.|.|.::.       |:....|.:|.||.:|.:||..||.||..:
  Rat   511 ILCETVKDFVAKVEKAQDRTLENTVVAEAVASKCSVLNEKLEQLLQALHAD-------------- 561

  Fly   592 RSLIARSIPVTPGSNAYLLNPNISIEKTE----------KDQINTKERRNSRSLRSSEKEALQCR 646
                :::..|.||     :.|.|..|.|:          |||: ..:.....|.::.:...:..|
  Rat   562 ----SQASRVPPG-----VGPAIPEEDTDTASEESLGESKDQL-VNDFGKPSSQKAVKPREIMLR 616

  Fly   647 ANSVKRAIYNVVEHSEPGRPKRYQRKLSITPFEALKLPTASGESTPCTSPLPIIPPINIISPTME 711
            |||:|:|:..|:|                   ||.|:
  Rat   617 ANSLKKAVRQVIE-------------------EAGKV---------------------------- 634

  Fly   712 TSRLTCISPLPDTRRDSVDENFFNSINLPAPRQFADSRRSSGVEVIQEIEEGANGETVYRKSRMS 776
                             :||                                   :||
  Rat   635 -----------------MDE-----------------------------------QTV------- 640

  Fly   777 LTGGANIDDAGNRLSPCSDAGENTPTERKVDFLRVPIHTGEPIVDPLCDYRPHEVFERTYYMTRE 841
                          .||                       || |.|.|||
  Rat   641 --------------QPC-----------------------EP-VSPSCDY--------------- 652

  Fly   842 MDKGKEKDKEKDKPVEIDKEKDTCVEKEGSMPAEKLVHTCNLQVPGVVVTPNPQNVYSSASITII 906
                   |.|.|:.    ||.||   ||
  Rat   653 -------DTEADEA----KEDDT---KE------------------------------------- 666

  Fly   907 DTDAQTTTEQSSSDDLGGEASDVLSAISNEECSVASEIFDKQDAGQTVGDIIQNMDASNFTHIDS 971
            ...|:||.:
  Rat   667 SLSAKTTPQ-------------------------------------------------------- 675

  Fly   972 PETSDETEAMPGESIMDDISSVLGHDITYALQDNTLTDDTTTLCSEHAGPPKPPRKKSLSALSRT 1036
               |.:.:|..|.|.:|.:                            |||
  Rat   676 ---SPDAQASRGHSQIDSV----------------------------AGP--------------- 694

  Fly  1037 QAHPRRRNSSPPRMARLARMDSDDNPQQFGFENIVFEIDNRCDDQKMREPPRYCSLAQFVEGNDI 1101

  Rat   695 ----------------------------------------------------------------- 694

  Fly  1102 ARQSFKQLMLEQHRGGDNDSDYPEHEQTPTNKGANLLATTSEDELSTQTAIKIEIQDIDATVRNL 1166
                                               .:|||.|:
  Rat   695 -----------------------------------AMATTKEN---------------------- 702

  Fly  1167 NSSMKPNTILTTSTSPTKKSGHGQDVKRITFDESCKKESFDDVNPNYPQISVVVRPPTPLRGDCI 1231

  Rat   703 ----------------------------------------------------------------- 702

  Fly  1232 KPTVSLLPVSSGGAMTVSMTCSGMLGVRAMNASEIRRHSSHAPGLAVREFDKDKDRRHSGFNPNQ 1296
                  |||     :...:.|.|:   ||              |||
  Rat   703 ------LPV-----LNTRIICPGL---RA--------------GLA------------------- 720

  Fly  1297 LTLDPEHARFLSSSPAASRRISCGSLFKKKNKKIGTKRSYGLFSVRFFVVAEPDFRLATLALIRP 1361
                                                                     |::|
  Rat   721 ---------------------------------------------------------ASIA---- 724

  Fly  1362 LIPLPNEALPNLQTLKGSKSSLFMGSTLFGFDHLASAEKDKEEKSGKDKEKTPTDETNRKLPIIN 1426

  Rat   725 ----------------------------------------------------------------- 724

  Fly  1427 PLVRLPNWPNLANGGGFISKCLLANADTLCAAVSPLMDPDETLLAGYHEKCVMNNYFGIGIDAKI 1491
                         |...|:|.||||.|...|  .|.:|||...|.||.||||||||||||:||||
  Rat   725 -------------GSSIINKMLLANVDPFGA--MPFIDPDPDSLDGYSEKCVMNNYFGIGLDAKI 774

  Fly  1492 SLDFHNKREEHPEKCRSRARNYMWYGVLGSKQLLQKTCKNLEQRVQLECDGQRIPLPELQGIVIL 1556
            ||:|:|||||||||||||.:|.|||||||:::|||::.||||||||||||||.||||.||||.:|
  Rat   775 SLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGIAVL 839

  Fly  1557 NIPSFMGGTNFWGSSKKDDIFLPPSFDDRVLEVVAVFGSVQMAASRLINLQHHRIAQCQSVQINI 1621
            ||||:.|||||||.:|:||||..|||||::|||||||.|||||.||:|.|||||||||::|:|.|
  Rat   840 NIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAVFDSVQMAVSRVIKLQHHRIAQCRTVKITI 904

  Fly  1622 LGDEEIPIQVDGEAWLQPPGMIRILHKNRVQMLCRNRSLELSLKSWQEKQR--------QHSISI 1678
            .|||.:|:|||||||:||||:|:|:||||.|||.|:|:.|.:||||::||:        :.::.|
  Rat   905 FGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDTGKPVLRTNLYI 969

  Fly  1679 QRDASSTASEHANSTDEVISERECYVLLNFIEAVSSLVKWVKFLIISHPALQHDLYEVACRASEA 1743
            ...|..       :|:||...|.|      .:|...|:..:......|..|:.:|.......|.|
  Rat   970 HPTADL-------ATEEVSQMRLC------SQAAEELITRICDAATIHCLLEQELAHAVNACSHA 1021

  Fly  1744 LESIHPQGKLLEGPSLRTKLVEVIDSSRQLYDDACTLLRDRGHSLILREDLETKLSAALANMEME 1808
            |...:|:   ......|....|:..:.:.||::..:||..| ..|.|....|.::|:||.::|||
  Rat  1022 LNKANPR---FPESLTRDTATEIAINVKALYNETESLLVGR-VPLHLESPHEERVSSALHSVEME 1082

  Fly  1809 LKKCSVQKCIDGKLRAYFNVLAPNEESD-------GRRKSRPFWV--RLRSGSTAGQQAFKPPLT 1864
            |:|.:       ::...:.:|.|||:.:       ...||..|.:  :.:......|:....|:
  Rat  1083 LRKLT-------EIPWLYYILRPNEDEEPPMDCTKRNNKSTVFRIVPKFKKEKAQKQKTSLQPV- 1139

  Fly  1865 NTREAANNWSVNEVVTWLETMQLSEYVDSFLKNDIRGKELLTLGRRDLKDLGVVKVGHVKRILQA 1929
                  .||...||..||:.:.|.||.:.|:::|:||.|||.|.||||||||:.||||:|||||.
  Rat  1140 ------QNWGTEEVAAWLDLLNLGEYKEIFIRHDVRGAELLHLERRDLKDLGIPKVGHMKRILQG 1198

  Fly  1930 IKDLSEN 1936
            ||:|..|
  Rat  1199 IKELERN 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34384	NP_001246971.1	PH	83..175	CDD:278594	54/91 (59%)
		PH_DGK_type2	84..180	CDD:270093	54/95 (57%)
		C1	196..245	CDD:197519	36/48 (75%)
		C1	268..318	CDD:197519	34/49 (69%)
		DAGKc	355..477	CDD:214487	100/121 (83%)
		DAGK_acc	1478..1635	CDD:279003	119/156 (76%)
		SAM_DGK-delta-eta	1869..1933	CDD:188906	36/63 (57%)
		SAM	1872..1935	CDD:197735	37/62 (60%)
Dgkh	XP_038949964.1	PH_DGK_type2	64..160	CDD:270093	54/95 (57%)
		C1_DGKeta_rpt1	144..229	CDD:410398	52/87 (60%)
		C1_DGKeta_rpt2	240..301	CDD:410444	40/60 (67%)
		DAGKc	331..453	CDD:214487	100/121 (83%)
		DAGKa	761..918	CDD:214486	119/156 (76%)
		SAM_DGK-eta	1138..1202	CDD:188975	37/70 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349552
Domainoid	1	1.000	262	1.000	Domainoid score	I1878
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H99373
Inparanoid	1	1.050	1054	1.000	Inparanoid score	I241
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29151at33208
OrthoFinder	1	1.000	-	-		FOG0002628
OrthoInspector	1	1.000	-	-		otm44900
orthoMCL	1	0.900	-	-		OOG6_102702
Panther	1	1.100	-	-	O	PTHR11255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.900