DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34384 and Dgkk

DIOPT Version :9

Sequence 1:	NP_001246971.1	Gene:	CG34384 / 5740362	FlyBaseID:	FBgn0085413	Length:	1936	Species:	Drosophila melanogaster
Sequence 2:	NP_808582.3	Gene:	Dgkk / 331374	MGIID:	3580254	Length:	1118	Species:	Mus musculus

Alignment Length:	1925	Identity:	452/1925 - (23%)
Similarity:	659/1925 - (34%)	Gaps:	906/1925 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VQRSPRGSRRSSPSSGRSSAC--SSGSISPVPIIPIISISHDGDESESESEI-----ETEPARLF 68
            ::|:|......:|.|     |  .|.::..:.::|       |::|.:.|.:     ..:|...:
Mouse     1 MERAPESWPEPTPES-----CLRMSPALHLLQVVP-------GEKSGTASPVLLPLPSPKPPITW 53

  Fly    69 QRRMSTKCTNNLAAIIKEGFLLKHTWSFQRWRRRYFRLKRNMLFYAKDEKCDVFDDIDLSDLCYF 133
            .|         :..|:|||.|||:..||:||:.||..::...|.:|.......|:.||||.:...
Mouse    54 SR---------IKKILKEGPLLKNCNSFRRWKLRYCLVQGQKLHFAHHPSFAHFETIDLSQVVLA 109

  Fly   134 ECGIKNVNHSFQIITPTRSLVLCAESRREMEDWLGSLKTATAPQRPRGDSFLI---EQHDILSNH 195
            |...:|:.|.|.:|||.|.:.|.|.:|::||:|:..:||.     .:|:...|   |.:..|...
Mouse   110 ESSCRNLCHGFCVITPHRKVSLVAPTRQDMEEWINIIKTV-----QQGEIRQIPAAENNPFLVGM 169

  Fly   196 HHWYATSHARPTYCNVCRDALSGVTSHGLSCEVCKCKVHKRCAAKSIANCKWTTLASVGKDIIEQ 260
            |:||::|:.|..:|||||:.:..::...::||||:.|.||.||.::..:|||.|| ||..|::..
Mouse   170 HYWYSSSNPRSHFCNVCRENIPALSRDAVTCEVCQVKSHKFCALRANKDCKWNTL-SVTDDLLLP 233

  Fly   261 ADGI-IMPHQWMEGNLPVSSMCAVCKKTCGSVLRLQDWRCLWCRATVHVACRPQMAVACPIGPAK 324
            ||.| .|||||:|||:|..|.|.||.|:|||..||||:|||||.:|||.||:.:.:..|..|..:
Mouse   234 ADEIQTMPHQWVEGNIPAGSQCVVCHKSCGSHHRLQDFRCLWCGSTVHGACQKRFSKECSFGSRR 298

  Fly   325 LSVVPPTSVHS-------ISTDDAWDVASPKGNFSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQ 382
            .|:||||::..       :.:.|.|::..|.....|||:|:||||||:||:.|||:|||.|||:|
Mouse   299 SSIVPPTALSDPRGDGQLVVSPDFWNLDWPLTCSCPLLIFINSKSGDHQGIIFLRKFKQYLNPSQ 363

  Fly   383 VFDLISTGPSLGLRLFRHFEMFRILVCSGDGSVGWVLSEIDRFNMHKQCQVAVMPLGTGNDLARV 447
            ||||...||..|:.:|::|..||:|||.|||||.||||.||.:.:|.:||:|::|||||||||||
Mouse   364 VFDLAKGGPEAGIAMFKNFARFRVLVCGGDGSVSWVLSTIDAYGLHDRCQLAIIPLGTGNDLARV 428

  Fly   448 LGWGSSCDDDTHLPQILERYESASTKMLDRWSIMVFEKAIPVPKTPKMSISTEQEAMLTGMVT-- 510
            ||||:.....|....||.|.|.|..::|||||:|:.|       ||:      |..:|.|.|.
Mouse   429 LGWGAVWSKGTSPLDILSRVEQAHVRILDRWSVMIRE-------TPR------QAPLLKGQVAMD 480

  Fly   511 -------------SANHHLRFIVETNDTQTLIRSTRNLCDTVDDLV-------CRISEHHKDDEQ 555
                         ||...|..|::......::.:||.||..|:|.|       .:|.::....|.
Mouse   481 IPRFEAAAIKNVESATTELNKILKAKYPTEMVIATRFLCSAVEDFVEDIVKAWHQIKQNSTAVES 545

  Fly   556 LAVKCDILRQKLNMLLDALQEEEIGAHSGDDLIATIRSLIARSIPVTPGSNAYLLNPNISIEKTE 620
            :.:|.|::..||::|:|.|.|:.:.|
Mouse   546 VILKSDLMYDKLSVLIDLLAEDAVAA--------------------------------------- 571

  Fly   621 KDQINTKERRNSRSLRSSEKEALQCRANSVKRAIYNVVEHSEPGRPKRYQRKLSITPFEALKLPT 685
                            |:|:.|                                          |
Mouse   572 ----------------SAERTA------------------------------------------T 578

  Fly   686 ASGESTPCTSPLPIIPPINIISPTMETSRLTCISPLPDTRRDSVDENFFNSINLPAPRQFADSRR 750
            |.|.                                                     |..||
Mouse   579 AYGS-----------------------------------------------------RSQAD--- 587

  Fly   751 SSGVEVIQEIEEGANGETVYRKSRMSLTGGANIDDAGNRLSPCSDAGENTPTERKVDFLRVPIHT 815

Mouse   588 ----------------------------------------------------------------- 587

  Fly   816 GEPIVDPLCDYRPHEVFERTYYMTREMDKGKEKDKEKDKPVEIDKEKDTCVEKEGSMPAEKLVHT 880
            |:|.| |..|:                               |.:.|....|:     |:||..:
Mouse   588 GKPFV-PQLDH-------------------------------IARAKLELAER-----AQKLQQS 615

  Fly   881 CNLQVPGVVVTPNPQNVYSSASITIIDTDAQTTTEQSSSDDLGGEASDVLSAISNEECSVASEIF 945
            ..|                     ||....|...|:|.
Mouse   616 LKL---------------------IIFQVEQVLDEESR--------------------------- 632

  Fly   946 DKQDAGQTVGDIIQNMDASNFTHIDSPETSDETEAMPGESIMDDISSVLGHDITYALQDNTLTDD 1010
                         |::...|||                       ||:...|
Mouse   633 -------------QSLSVKNFT-----------------------SSLFLGD------------- 648

  Fly  1011 TTTLCSEHAGPPKPPRKKSLSALSRTQAHPRRRNSSPPRMARLARMDSDDNPQQFGFENIVFEID 1075

Mouse   649 ----------------------------------------------------------------- 648

  Fly  1076 NRCDDQKMREPPRYCSLAQFVEGNDIARQSFKQLMLEQHRGGDNDSDYPEHEQTPTNKGANLLAT 1140
                                                    |.|:|||  :::|:|
Mouse   649 ----------------------------------------GDDDDSD--DYDQSP---------- 661

  Fly  1141 TSEDELSTQTAIKIEIQDIDATVRNLNSSMKPNTILTTSTSPTKKSGHGQDVKRITFDESCKKES 1205

Mouse   662 ----------------------------------------------------------------- 661

  Fly  1206 FDDVNPNYPQISVVVRPPTPLRGDCIKPTVSLLPVSSGGAMTVSMTCSGMLGVRAMNASEIRRHS 1270
                                                                          ||.
Mouse   662 --------------------------------------------------------------RHR 664

  Fly  1271 SHAPGLAVREFDKDKDRRHSGFNPNQLTLDPEHARFLSSSPAASRRISCGSLFKKKNKKIGTKRS 1335
            |...                               .|.|.|:
Mouse   665 SRCD-------------------------------ILCSIPS----------------------- 675

  Fly  1336 YGLFSVRFFVVAEPDFRLATLALIRPLIPLPNEALPNLQTLKGSKSSLFMGSTLFGFDHLASAEK 1400
                                         |.||.|.||.                 .:||..|
Mouse   676 -----------------------------LRNEDLDNLD-----------------LEHLHIA-- 692

  Fly  1401 DKEEKSGKDKEKTPTDETNRKLPIINPLVRLPNWPNLANGGGFISKCLLANADTLCAAVSPLMDP 1465
                           .||.|
Mouse   693 ---------------PETIR--------------------------------------------- 697

  Fly  1466 DETLLAGYHEKCVMNNYFGIGIDAKISLDFHNKREEHPEKCRSRARNYMWYGVLGSKQLLQKTCK 1530
                   :.||||||||||||:||||||:|:::||||||:..||.:|.:|||:||||:|||::.:
Mouse   698 -------FKEKCVMNNYFGIGLDAKISLEFNSRREEHPEQYNSRLKNKIWYGLLGSKELLQRSYR 755

  Fly  1531 NLEQRVQLECDGQRIPLPELQGIVILNIPSFMGGTNFWGSSKKDDIFLPPSFDDRVLEVVAVFGS 1595
            .||:|:.|||||:.:.||.|||||:|||.|:.||.||||.::....:..|:.:|..|||||:|||
Mouse   756 KLEERIHLECDGEAVSLPNLQGIVVLNITSYAGGVNFWGRNRATTEYDVPAINDGKLEVVAIFGS 820

  Fly  1596 VQMAASRLINLQHHRIAQCQSVQINILGDEEIPIQVDGEAWLQPPGMIRILHKNRVQMLCRNRSL 1660
            ||||.||::|||.||||||..|.|.|.|::.:|:|||||||:|.||:|:|.:||..|||.|:|..
Mouse   821 VQMAMSRIVNLQQHRIAQCHEVVITIDGEDGVPVQVDGEAWIQKPGLIKIKYKNVAQMLMRDRDF 885

  Fly  1661 ELSLKSWQEK---------------QRQHSISIQRDASSTASEH-ANSTDEVIS--------ERE 1701
            |.|:|:|:.|               :.|.|:|   |......:| |...:.:||        .:.
Mouse   886 ENSMKTWESKHTEIQAVQPPHLDFQESQDSLS---DGEYAQMQHLARLAENLISRLTDLSKVHQH 947

  Fly  1702 CYVLLNFIEAVSSLVKWVKFLIISHPALQHDLYEVACRASEALESIHPQGKLLEGPSLRTKLVEV 1766
            ..||::.:.|.::::..|.:       .|....|....:...:|::.           ||..|:|
Mouse   948 VSVLMDSVNASANILNDVFY-------SQDSGNEAGAASCIPIETLS-----------RTDAVDV 994

  Fly  1767 IDSSRQLYDDACTLLRDRGHSLILREDLETK--LSAALANMEMELKKCSVQKCIDGKLRAYFNVL 1829
            ..|.:.||||....|.:.     |..|.|.:  |..||..|..||::.   ..|....:.:|
Mouse   995 TFSLKGLYDDTKAFLDEN-----LLRDAEDRAMLQTALDAMNTELRRI---LAIGWLSQIFF--- 1048

  Fly  1830 APNEE-SDGRRKSRPFWVRL-RSGSTAGQQAFKPPLTNTR 1867
             |.|: ||.|..||.|.::. :.|....::..:.|.::.|
Mouse  1049 -PEEQASDTRSLSRRFRIKFPKLGKKKQREEGEKPKSSQR 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34384	NP_001246971.1	PH	83..175	CDD:278594	36/91 (40%)
		PH_DGK_type2	84..180	CDD:270093	35/95 (37%)
		C1	196..245	CDD:197519	19/48 (40%)
		C1	268..318	CDD:197519	29/49 (59%)
		DAGKc	355..477	CDD:214487	71/121 (59%)
		DAGK_acc	1478..1635	CDD:279003	94/156 (60%)
		SAM_DGK-delta-eta	1869..1933	CDD:188906
		SAM	1872..1935	CDD:197735
Dgkk	NP_808582.3	PH	59..147	CDD:278594	34/87 (39%)
		PH_DGK_type2	60..154	CDD:270093	36/98 (37%)
		C1	170..219	CDD:237996	19/48 (40%)
		C1	242..292	CDD:237996	29/49 (59%)
		DAGKc	336..458	CDD:214487	71/121 (59%)
		DAGK_acc	703..860	CDD:295305	94/156 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846080
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29151at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102702
Panther	1	1.100	-	-	LDO	PTHR11255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850