Protein Alignment CG34384 and Dgkk

DIOPT Version :10

• Sequence 1: NP_001246971.1
• Gene: CG34384 / 5740362
• FlyBaseID: FBgn0085413
• Length: 1936
• Species: Drosophila melanogaster
• Sequence 2: NP_808582.3
• Gene: Dgkk / 331374
• MGIID: 3580254
• Length: 1118
• Species: Mus musculus
• Alignment Length: 1925
• Identity: 452/1925 - (23%)
• Similarity: 659/1925 - (34%)
• Gaps: 906/1925 - (47%)

  Fly    11 VQRSPRGSRRSSPSSGRSSAC--SSGSISPVPIIPIISISHDGDESESESEI-----ETEPARLF 68
            ::|:|......:|.|     |  .|.::..:.::|       |::|.:.|.:     ..:|...:
Mouse     1 MERAPESWPEPTPES-----CLRMSPALHLLQVVP-------GEKSGTASPVLLPLPSPKPPITW 53

  Fly    69 QRRMSTKCTNNLAAIIKEGFLLKHTWSFQRWRRRYFRLKRNMLFYAKDEKCDVFDDIDLSDLCYF 133
            .|         :..|:|||.|||:..||:||:.||..::...|.:|.......|:.||||.:...
Mouse    54 SR---------IKKILKEGPLLKNCNSFRRWKLRYCLVQGQKLHFAHHPSFAHFETIDLSQVVLA 109

  Fly   134 ECGIKNVNHSFQIITPTRSLVLCAESRREMEDWLGSLKTATAPQRPRGDSFLI---EQHDILSNH 195
            |...:|:.|.|.:|||.|.:.|.|.:|::||:|:..:||.     .:|:...|   |.:..|...
Mouse   110 ESSCRNLCHGFCVITPHRKVSLVAPTRQDMEEWINIIKTV-----QQGEIRQIPAAENNPFLVGM 169

  Fly   196 HHWYATSHARPTYCNVCRDALSGVTSHGLSCEVCKCKVHKRCAAKSIANCKWTTLASVGKDIIEQ 260
            |:||::|:.|..:|||||:.:..::...::||||:.|.||.||.::..:|||.|| ||..|::..
Mouse   170 HYWYSSSNPRSHFCNVCRENIPALSRDAVTCEVCQVKSHKFCALRANKDCKWNTL-SVTDDLLLP 233

  Fly   261 ADGI-IMPHQWMEGNLPVSSMCAVCKKTCGSVLRLQDWRCLWCRATVHVACRPQMAVACPIGPAK 324
            ||.| .|||||:|||:|..|.|.||.|:|||..||||:|||||.:|||.||:.:.:..|..|..:
Mouse   234 ADEIQTMPHQWVEGNIPAGSQCVVCHKSCGSHHRLQDFRCLWCGSTVHGACQKRFSKECSFGSRR 298

  Fly   325 LSVVPPTSVHS-------ISTDDAWDVASPKGNFSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQ 382
            .|:||||::..       :.:.|.|::..|.....|||:|:||||||:||:.|||:|||.|||:|
Mouse   299 SSIVPPTALSDPRGDGQLVVSPDFWNLDWPLTCSCPLLIFINSKSGDHQGIIFLRKFKQYLNPSQ 363

  Fly   383 VFDLISTGPSLGLRLFRHFEMFRILVCSGDGSVGWVLSEIDRFNMHKQCQVAVMPLGTGNDLARV 447
            ||||...||..|:.:|::|..||:|||.|||||.||||.||.:.:|.:||:|::|||||||||||
Mouse   364 VFDLAKGGPEAGIAMFKNFARFRVLVCGGDGSVSWVLSTIDAYGLHDRCQLAIIPLGTGNDLARV 428

  Fly   448 LGWGSSCDDDTHLPQILERYESASTKMLDRWSIMVFEKAIPVPKTPKMSISTEQEAMLTGMVT-- 510
            ||||:.....|....||.|.|.|..::|||||:|:.|       ||:      |..:|.|.|.
Mouse   429 LGWGAVWSKGTSPLDILSRVEQAHVRILDRWSVMIRE-------TPR------QAPLLKGQVAMD 480

  Fly   511 -------------SANHHLRFIVETNDTQTLIRSTRNLCDTVDDLV-------CRISEHHKDDEQ 555
                         ||...|..|::......::.:||.||..|:|.|       .:|.::....|.
Mouse   481 IPRFEAAAIKNVESATTELNKILKAKYPTEMVIATRFLCSAVEDFVEDIVKAWHQIKQNSTAVES 545

  Fly   556 LAVKCDILRQKLNMLLDALQEEEIGAHSGDDLIATIRSLIARSIPVTPGSNAYLLNPNISIEKTE 620
            :.:|.|::..||::|:|.|.|:.:.|
Mouse   546 VILKSDLMYDKLSVLIDLLAEDAVAA--------------------------------------- 571

  Fly   621 KDQINTKERRNSRSLRSSEKEALQCRANSVKRAIYNVVEHSEPGRPKRYQRKLSITPFEALKLPT 685
                            |:|:.|                                          |
Mouse   572 ----------------SAERTA------------------------------------------T 578

  Fly   686 ASGESTPCTSPLPIIPPINIISPTMETSRLTCISPLPDTRRDSVDENFFNSINLPAPRQFADSRR 750
            |.|.                                                     |..||
Mouse   579 AYGS-----------------------------------------------------RSQAD--- 587

  Fly   751 SSGVEVIQEIEEGANGETVYRKSRMSLTGGANIDDAGNRLSPCSDAGENTPTERKVDFLRVPIHT 815
                                                                             
Mouse   588 ----------------------------------------------------------------- 587

  Fly   816 GEPIVDPLCDYRPHEVFERTYYMTREMDKGKEKDKEKDKPVEIDKEKDTCVEKEGSMPAEKLVHT 880
            |:|.| |..|:                               |.:.|....|:     |:||..:
Mouse   588 GKPFV-PQLDH-------------------------------IARAKLELAER-----AQKLQQS 615

  Fly   881 CNLQVPGVVVTPNPQNVYSSASITIIDTDAQTTTEQSSSDDLGGEASDVLSAISNEECSVASEIF 945
            ..|                     ||....|...|:|.
Mouse   616 LKL---------------------IIFQVEQVLDEESR--------------------------- 632

  Fly   946 DKQDAGQTVGDIIQNMDASNFTHIDSPETSDETEAMPGESIMDDISSVLGHDITYALQDNTLTDD 1010
                         |::...|||                       ||:...|
Mouse   633 -------------QSLSVKNFT-----------------------SSLFLGD------------- 648

  Fly  1011 TTTLCSEHAGPPKPPRKKSLSALSRTQAHPRRRNSSPPRMARLARMDSDDNPQQFGFENIVFEID 1075
                                                                             
Mouse   649 ----------------------------------------------------------------- 648

  Fly  1076 NRCDDQKMREPPRYCSLAQFVEGNDIARQSFKQLMLEQHRGGDNDSDYPEHEQTPTNKGANLLAT 1140
                                                    |.|:|||  :::|:|
Mouse   649 ----------------------------------------GDDDDSD--DYDQSP---------- 661

  Fly  1141 TSEDELSTQTAIKIEIQDIDATVRNLNSSMKPNTILTTSTSPTKKSGHGQDVKRITFDESCKKES 1205
                                                                             
Mouse   662 ----------------------------------------------------------------- 661

  Fly  1206 FDDVNPNYPQISVVVRPPTPLRGDCIKPTVSLLPVSSGGAMTVSMTCSGMLGVRAMNASEIRRHS 1270
                                                                          ||.
Mouse   662 --------------------------------------------------------------RHR 664

  Fly  1271 SHAPGLAVREFDKDKDRRHSGFNPNQLTLDPEHARFLSSSPAASRRISCGSLFKKKNKKIGTKRS 1335
            |...                               .|.|.|:
Mouse   665 SRCD-------------------------------ILCSIPS----------------------- 675

  Fly  1336 YGLFSVRFFVVAEPDFRLATLALIRPLIPLPNEALPNLQTLKGSKSSLFMGSTLFGFDHLASAEK 1400
                                         |.||.|.||.                 .:||..|
Mouse   676 -----------------------------LRNEDLDNLD-----------------LEHLHIA-- 692

  Fly  1401 DKEEKSGKDKEKTPTDETNRKLPIINPLVRLPNWPNLANGGGFISKCLLANADTLCAAVSPLMDP 1465
                           .||.|
Mouse   693 ---------------PETIR--------------------------------------------- 697

  Fly  1466 DETLLAGYHEKCVMNNYFGIGIDAKISLDFHNKREEHPEKCRSRARNYMWYGVLGSKQLLQKTCK 1530
                   :.||||||||||||:||||||:|:::||||||:..||.:|.:|||:||||:|||::.:
Mouse   698 -------FKEKCVMNNYFGIGLDAKISLEFNSRREEHPEQYNSRLKNKIWYGLLGSKELLQRSYR 755

  Fly  1531 NLEQRVQLECDGQRIPLPELQGIVILNIPSFMGGTNFWGSSKKDDIFLPPSFDDRVLEVVAVFGS 1595
            .||:|:.|||||:.:.||.|||||:|||.|:.||.||||.::....:..|:.:|..|||||:|||
Mouse   756 KLEERIHLECDGEAVSLPNLQGIVVLNITSYAGGVNFWGRNRATTEYDVPAINDGKLEVVAIFGS 820

  Fly  1596 VQMAASRLINLQHHRIAQCQSVQINILGDEEIPIQVDGEAWLQPPGMIRILHKNRVQMLCRNRSL 1660
            ||||.||::|||.||||||..|.|.|.|::.:|:|||||||:|.||:|:|.:||..|||.|:|..
Mouse   821 VQMAMSRIVNLQQHRIAQCHEVVITIDGEDGVPVQVDGEAWIQKPGLIKIKYKNVAQMLMRDRDF 885

  Fly  1661 ELSLKSWQEK---------------QRQHSISIQRDASSTASEH-ANSTDEVIS--------ERE 1701
            |.|:|:|:.|               :.|.|:|   |......:| |...:.:||        .:.
Mouse   886 ENSMKTWESKHTEIQAVQPPHLDFQESQDSLS---DGEYAQMQHLARLAENLISRLTDLSKVHQH 947

  Fly  1702 CYVLLNFIEAVSSLVKWVKFLIISHPALQHDLYEVACRASEALESIHPQGKLLEGPSLRTKLVEV 1766
            ..||::.:.|.::::..|.:       .|....|....:...:|::.           ||..|:|
Mouse   948 VSVLMDSVNASANILNDVFY-------SQDSGNEAGAASCIPIETLS-----------RTDAVDV 994

  Fly  1767 IDSSRQLYDDACTLLRDRGHSLILREDLETK--LSAALANMEMELKKCSVQKCIDGKLRAYFNVL 1829
            ..|.:.||||....|.:.     |..|.|.:  |..||..|..||::.   ..|....:.:|
Mouse   995 TFSLKGLYDDTKAFLDEN-----LLRDAEDRAMLQTALDAMNTELRRI---LAIGWLSQIFF--- 1048

  Fly  1830 APNEE-SDGRRKSRPFWVRL-RSGSTAGQQAFKPPLTNTR 1867
             |.|: ||.|..||.|.::. :.|....::..:.|.::.|
Mouse  1049 -PEEQASDTRSLSRRFRIKFPKLGKKKQREEGEKPKSSQR 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34384	NP_001246971.1	PH_DGK_type2	84..180	CDD:270093	35/95 (37%)
		C1_DGK_typeII_rpt1	192..251	CDD:410350	24/58 (41%)
		C1_DGK_typeII_rpt2	268..321	CDD:410402	30/52 (58%)
		DAGKc	355..477	CDD:214487	71/121 (59%)
		DAGKa	1478..1635	CDD:214486	94/156 (60%)
		SAM_DGK-delta-eta	1869..1933	CDD:188906
Dgkk	NP_808582.3	PH_DGK_type2	60..154	CDD:270093	36/98 (37%)
		C1_DGK_typeII_rpt1	166..225	CDD:410350	25/59 (42%)
		C1_DGK_typeII_rpt2	242..295	CDD:410402	30/52 (58%)
		DAGKc	336..458	CDD:214487	71/121 (59%)
		DAGK_acc	703..860	CDD:470579	94/156 (60%)