DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34384 and rdgA

DIOPT Version :9

Sequence 1:	NP_001246971.1	Gene:	CG34384 / 5740362	FlyBaseID:	FBgn0085413	Length:	1936	Species:	Drosophila melanogaster
Sequence 2:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster

Alignment Length:	1237	Identity:	262/1237 - (21%)
Similarity:	408/1237 - (32%)	Gaps:	383/1237 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HLKLDTLHVQRSPRGSRRSSP---SSGR--------SSACSS------GSISPVPI--------- 41
            ||.||.        ||...||   :|||        |:.|||      |:...:|:
  Fly   359 HLPLDP--------GSPPISPCSSNSGRLPALAPIISTPCSSADADDAGAAMGLPVRARRRSISR 415

  Fly    42 ----------IPIISISHDG-DESESESEIETEPARLFQRRMST------------KCTNNLAAI 83
                      ..:.::||:. |.|.::|.::|..:......|:|            ..:::.|.:
  Fly   416 QEAIFVEPTGNSLENVSHEEVDNSNTKSSVDTADSLDEASTMATCGSPGAAGGSGASSSHHNAFV 480

  Fly    84 IKEGFLLKHTWSFQRWRRR-----YFRLKRNMLFYAKDEKCDVFDDIDLSDLCYFECGIKNVN-- 141
            :::.:|:  ....:|.|..     :.:|..|    ||.|:..     ..:|.|:..  :.|:|
  Fly   481 VRDIYLM--VPDLKRDRAASVDSCFSKLSSN----AKTEELQ-----PSADGCFLT--VPNINAT 532

  Fly   142 --HSFQIITPTRSLVLCAESRREMEDWLGSL------KTATAPQRPRGDSFLIE-QHDILSNHHH 197
              .|..|:.||..     ::|.:.....||.      :||:|....|....:.: ..:.:...|:
  Fly   533 RSRSVDIVLPTDE-----QARYKALSMTGSTVTYADGRTASASNSRRPIRIVPDWTENAVQGEHY 592

  Fly   198 WYATSHARPTYCNVCRDALSGVTSHGLSCEVCKCKVHKRCA----AKSIANCKWTTLASVGKDII 258
            |..|| |....|.:..:.:.  :...:.|..|:...|..|.    .||...|| .|...||  |.
  Fly   593 WKPTS-ASGDLCCLNEECIK--SGQRMKCSACQLVAHHNCIPFVNEKSTLACK-PTYRDVG--IR 651

  Fly   259 EQADGIIMPHQWMEGNLPVSSMCAVCKKTCGSVLRLQD--------------WRCLWCRATVH-- 307
            :..:.....|.|:...|....    ||: ||....::.              ..|.||....|
  Fly   652 QYREQTTTHHHWVHRKLEKGK----CKQ-CGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNK 711

  Fly   308 VACRPQMAVA--CPIGPAKLSVVPPTSVHSISTDDAWDVASP-KGNFS----------------- 352
            .||..|..:.  |.:|.....:|||          :|.|..| ||||.
  Fly   712 EACFNQAKIGEECRLGNYAPIIVPP----------SWIVKLPTKGNFKSSIRVSNKNNAASGSGG 766

  Fly   353 ---------------------------------------------PLLVFVNSKSGDNQGVKFLR 372
                                                         |::||:|.|||.|||.|.|.
  Fly   767 GGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLG 831

  Fly   373 RFKQLLNPAQVFDLISTGPSLGLRLFRHFEMFRILVCSGDGSVGWVLSEIDRFN--MHKQCQVAV 435
            :|:.||||.|||||...||.:||.:||.....|:|.|.|||:||||||.:|:..  :.....|.|
  Fly   832 KFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGV 896

  Fly   436 MPLGTGNDLARVLGWGSSC----DDDTHLPQILERYESASTKMLDRWSIMVFEKAIP-------- 488
            :||||||||||.||||.|.    ..|..:.:||.....:...::|||.:    |..|
  Fly   897 LPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRV----KVTPNDDVTDDH 957

  Fly   489 ----VPKTPKMSISTEQEAMLTGMVTSANHHLR---------------FIVETNDTQTLIRSTRN 534
                .|..|...|:......:...:....|..|               :..:......::|..||
  Fly   958 VDRSKPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRN 1022

  Fly   535 L-------CDTVD------DLVCRI-----------SEHHKDDEQLAVKCDI---LRQKLNMLLD 572
            |       ||..|      |..|..           ..|..:|...|.|..|   |.:.:.:...
  Fly  1023 LSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPWNDSFGASKPSIDDGLMEVVGLTTY 1087

  Fly   573 ALQEEEIGAHSGDDLIATIRS---LIARSIPVTPGSNAYLLNPN-ISIEKTEKDQINTKERRNSR 633
            .|...:.|.|.  ..|...|.   :..|:||:.....|..:.|: |.||...|..:.:|.:....
  Fly  1088 QLPMLQAGMHG--TCICQCRKARIITKRTIPMQVDGEACRVKPSVIEIELLNKALMLSKRKHGRG 1150

  Fly   634 SLRSSEKEALQCRANSVKRAIYNVVEHSEPGRPKRYQRKLSITPFEALKLPTASGESTPCTSPLP 698
            .::.:..|.:|.....|....|....:.     |...|||      |.||.....|| .|..
  Fly  1151 DVQVNPLEKMQLHILRVTMQQYEQYHYD-----KEMLRKL------ANKLGQIEIES-QCDL--- 1200

  Fly   699 IIPPINIISPTMETSRLTCISPLPDTRRDSVDENFFNSINLPAPRQ---FADSRRSSGVEVIQEI 760
                                    :..|:.::..|..||:.|...|   |.||
  Fly  1201 ------------------------EHVRNMLNTKFEESISYPKVSQDWCFIDS------------ 1229

  Fly   761 EEGANGETVYRKSRMSLTGGANIDDAGNRLSPCSDAGENTPTERKVDFLRVPIHTGEPIVDPLCD 825
               ...|..:|           ||.|...|....|..        :|.|.:..|....:......
  Fly  1230 ---CTAEHYFR-----------IDRAQEHLHYICDIA--------IDELYILDHEAATMPQTPDQ 1272

  Fly   826 YRPHEVFERTYYMT--REMDKGKEK---DKEKD-----KPVEIDKEKDTCVE----------KEG 870
            .|....|.:.....  |:||:.:.:   ..::|     ||:::.|.|...:|          :.|
  Fly  1273 ERSFAAFSQRQAQNERRQMDQAQGRGPGSTDEDLQIGSKPIKVMKWKSPILEQTSDAILLAAQSG 1337

  Fly   871 SMPAEKLVHTCNLQVPGVVVTPNPQNVYSSAS-------ITIIDTDAQTTTEQSSSDDLGGEASD 928
            .:...:.:|.....:..  |..|.|.....|.       :..|...|.......:..:||..|..
  Fly  1338 DLNMLRALHEQGYSLQS--VNKNGQTALHFACKYNHRDIVKYIIASATRRLINMADKELGQTALH 1400

  Fly   929 VLSAISNEECSV----ASEIFDKQDA-GQTVGDIIQNMDASNF-THIDSPETSDETEAMPGESIM 987
            :.:..:..:..|    |....|..|: |.|...:..|.:|:.. |:::|.:.:     .|.:..:
  Fly  1401 IAAEQNRRDICVMLVAAGAHLDTLDSGGNTPMMVAFNKNANEIATYLESKQGT-----QPVDGWL 1460

  Fly   988 DD 989
            ||
  Fly  1461 DD 1462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34384	NP_001246971.1	PH	83..175	CDD:278594	21/106 (20%)
		PH_DGK_type2	84..180	CDD:270093	22/110 (20%)
		C1	196..245	CDD:197519	12/52 (23%)
		C1	268..318	CDD:197519	14/67 (21%)
		DAGKc	355..477	CDD:214487	60/127 (47%)
		DAGK_acc	1478..1635	CDD:279003
		SAM_DGK-delta-eta	1869..1933	CDD:188906
		SAM	1872..1935	CDD:197735
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	12/51 (24%)
		C1_1	661..725	CDD:278556	14/68 (21%)
		LCB5	813..1140	CDD:224513	99/332 (30%)
		DAGKc	814..942	CDD:214487	60/127 (47%)
		DAGKa	969..1123	CDD:214486	26/155 (17%)
		ANK	1329..1447	CDD:238125	20/119 (17%)
		ANK repeat	1329..1356	CDD:293786	2/28 (7%)
		Ank_2	1330..1425	CDD:289560	14/96 (15%)
		ANK repeat	1358..1391	CDD:293786	5/32 (16%)
		ANK repeat	1393..1425	CDD:293786	6/31 (19%)
		Ank_2	1399..>1459	CDD:289560	11/64 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16095at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950