DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34384 and Dgkd

DIOPT Version :9

Sequence 1:	NP_001246971.1	Gene:	CG34384 / 5740362	FlyBaseID:	FBgn0085413	Length:	1936	Species:	Drosophila melanogaster
Sequence 2:	XP_006529534.1	Gene:	Dgkd / 227333	MGIID:	2138334	Length:	1227	Species:	Mus musculus

Alignment Length:	1929	Identity:	601/1929 - (31%)
Similarity:	790/1929 - (40%)	Gaps:	793/1929 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GSISPVPIIPIISISHDGDESESESEIETEPA--RLFQRRMSTKCTNNLAAIIKEGFLLKHTWSF 96
            |...|.|..|        .|..|:||.|.||.  :...|::||........|:|||.|.|...||
Mouse    11 GPPQPPPPPP--------PEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTILKEGMLTKQNNSF 67

  Fly    97 QRWRRRYFRLKRNMLFYAKDEKCDVFDDIDLSDLCYFECGIKNVNHSFQIITPTRSLVLCAESRR 161
            ||.:||||:|:...|:|||..|..:||::||:|....|...||||:||.:|||.|.|:|||::|:
Mouse    68 QRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITPCRKLILCADNRK 132

  Fly   162 EMEDWLGSLKTATAPQRPRGDSFLIEQHDILSNHHHWYATSHARPTYCNVCRDALSGVTSHGLSC 226
            |||||:.:|||....:......:.:   |..|..|:|||.||||||||||||:.|||||||||||
Mouse   133 EMEDWIAALKTVQNKEHFEPTQYSM---DHFSGMHNWYACSHARPTYCNVCREVLSGVTSHGLSC 194

  Fly   227 EVCKCKVHKRCAAKSIANCKWTTLASVGKDIIEQADGIIMPHQWMEGNLPVSSMCAVCKKTCGSV 291
            ||||.|.|||||.::.:|||||||||:||||||..|||.|||||:|||||||:.|.||.||||||
Mouse   195 EVCKFKAHKRCAVRATSNCKWTTLASIGKDIIEDEDGIAMPHQWLEGNLPVSAKCIVCDKTCGSV 259

  Fly   292 LRLQDWRCLWCRATVHVACRPQMAVACPIGPAKLSVVPPTSVHSISTDDAWDVASPKGNFSPLLV 356
            |||||||||||:|.||.:|:..:.:.||:|..|:||:|||:::||.:|..|....|....|||||
Mouse   260 LRLQDWRCLWCKAMVHTSCKESLVMKCPLGLCKVSVIPPTALNSIDSDGFWKATCPPSCTSPLLV 324

  Fly   357 FVNSKSGDNQGVKFLRRFKQLLNPAQVFDLISTGPSLGLRLFRHFEMFRILVCSGDGSVGWVLSE 421
            ||||||||||||||||||||||||||||||::.||.||||||:.|:.||||||.|||||||||||
Mouse   325 FVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSE 389

  Fly   422 IDRFNMHKQCQVAVMPLGTGNDLARVLGWGSSCDDDTHLPQILERYESASTKMLDRWSIMVFEKA 486
            ||..|:|||||:.|:||||||||||||||||:|||||.|||||.:.|.||||||||||:|.:|..
Mouse   390 IDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILAKLERASTKMLDRWSVMAYETK 454

  Fly   487 IP-----VPKTPKMSISTEQEAMLTGMVTSANHHLRFIVETNDTQTLIRSTRNLCDTVDDLVCRI 546
            :|     ...|...|..:|.:.:|. ...|...||..|:.::....:|.|.:.||:||.|.|.|:
Mouse   455 LPRQASSSTVTEDFSEDSEVQQILF-YEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARV 518

  Fly   547 -------SEHHKDDEQLAVKCDILRQKLNMLLDALQEE------------------EIGAHSGDD 586
                   :|..::.|.:|.||.:|::||:.||..|.:|                  |.|..||:.
Mouse   519 GKAYEKTTESSQESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLSNPPPTIAEEAEDGDGSGNI 583

  Fly   587 LIATIRSLIARSIPVTPGSNAYLLNPNISIEKTEKDQINTKERRNSRSLRSSEKEALQCRANSVK 651
            ..:|...|:..:.|..|    .:..|                           :|.|..||||:|
Mouse   584 CSSTGDHLVGSACPSRP----QIFRP---------------------------REQLMLRANSLK 617

  Fly   652 RAIYNVVEHSEPGRPKRYQRKLSITPFEALKLPTASGESTPCTSPLPIIPPINIISPTMETSRLT 716
            :||..::||:|
Mouse   618 KAIRQIIEHTE------------------------------------------------------ 628

  Fly   717 CISPLPDTRRDSVDENFFNSINLPAPRQFADSRRSSGVEVIQEIEEGANGETVYRKSRMSLTGGA 781
                      .:|||
Mouse   629 ----------KAVDE-------------------------------------------------- 633

  Fly   782 NIDDAGNRLSPCSDAGENTPTERKVDFLRVPIHTGEPIVDPLCDYRPHEVFERTYYMTREMDKGK 846
                            :|..|:.:..|:                                  .|.
Mouse   634 ----------------QNAQTQEQQGFV----------------------------------LGL 648

  Fly   847 EKDKEKDKPVEIDKEKDTCVEKEGSMPAEKLVHTCNLQVPGVVVTPNPQNVYSSASITIIDTDAQ 911
            .:.::||                                                    :.||.:
Mouse   649 SESEKKD----------------------------------------------------LKTDNR 661

  Fly   912 TTTEQSSSDDLGGEASDVLSAISNEECSVASEIFDKQDAGQTVGDIIQNMDASNFTHIDSPETSD 976
            ..|                |::.:|.|.:|.
Mouse   662 VCT----------------SSVHSESCVIAK---------------------------------- 676

  Fly   977 ETEAMPGESIMDDISSVLGHDITYALQDNTLTDDTTTLCSEHAGPPKPPRKKSLSALSRTQAHPR 1041
                  |.|                                                       :
Mouse   677 ------GRS-------------------------------------------------------Q 680

  Fly  1042 RRNSSPPRMARLARMDSDDNPQQFGFENIVFEIDNRCDDQKMREPPRYCSLAQFVEGNDIARQSF 1106
            |:.|..|                  .|.:|
Mouse   681 RKASRAP------------------CEKLV----------------------------------- 692

  Fly  1107 KQLMLEQHRGGDNDSDYPEHEQTPTNKGANLLATTSEDELSTQTAIKIEIQDIDATVRNLNSSMK 1171
                                     :||.:|.::.|
Mouse   693 -------------------------SKGLSLGSSAS----------------------------- 703

  Fly  1172 PNTILTTSTSPTKKSGHGQDVKRITFDESCKKESFDDVNPNYPQISVVVRPPTPLRGDCIKPTVS 1236

Mouse   704 ----------------------------------------------------------------- 703

  Fly  1237 LLPVSSGGAMTVSMTCSGMLGVRAMNASEIRRHSSHAPGLAVREFDKDKDRRHSGFNPNQLTLDP 1301
             ||                                  ||...|
Mouse   704 -LP----------------------------------PGTGSR---------------------- 711

  Fly  1302 EHARFLSSSPAASRRISCGSLFKKKNKKIGTKRSYGLFSVRFFVVAEPDFRLATLALIRPLIPLP 1366

Mouse   712 ----------------------------------------------------------------- 711

  Fly  1367 NEALPNLQTLKGSKSSLFMGSTLFGFDHLASAEKDKEEKSGKDKEKTPTDETNRKLPIINPLVR- 1430
             ::||.|.|                                               .|:.|.||
Mouse   712 -DSLPALNT-----------------------------------------------KILYPSVRA 728

  Fly  1431 -----LPNWPNLANGGGFISKCLLANADTLCAAVSPLMDPDETLLAGYHEKCVMNNYFGIGIDAK 1490
                 ||       ||..||: ||.|||...|      :|:.  |..|.||||||||||||:|||
Mouse   729 GMSGSLP-------GGSVISR-LLINADPFNA------EPEN--LEYYTEKCVMNNYFGIGLDAK 777

  Fly  1491 ISLDFHNKREEHPEKCRSRARNYMWYGVLGSKQLLQKTCKNLEQRVQLECDGQRIPLPELQGIVI 1555
            |||||:|||:|||||||||.:|.|||||||:|:||.:|.:||||:|.|||||:.||||.||||.:
Mouse   778 ISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYRNLEQKVLLECDGRPIPLPSLQGIAV 842

  Fly  1556 LNIPSFMGGTNFWGSSKKDDIFLPPSFDDRVLEVVAVFGSVQMAASRLINLQHHRIAQCQSVQIN 1620
            |||||:.|||||||.:|:||.|..|||||::|||||||||:|||.||:|.|||||||||::|:|:
Mouse   843 LNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIKLQHHRIAQCRTVKIS 907

  Fly  1621 ILGDEEIPIQVDGEAWLQPPGMIRILHKNRVQMLCRNRSLELSLKSWQEKQRQHSISIQRDASST 1685
            |||||.:|:|||||||:||||.|||:||||.|.|.|:|:.|.:||||::||:   ..:.|..|
Mouse   908 ILGDEGVPVQVDGEAWIQPPGYIRIVHKNRAQTLTRDRAFENTLKSWEDKQK---CELSRPPS-- 967

  Fly  1686 ASEHANSTDEVISERECYVLLNFIEAVSSLVKWVKFLIISHPALQHDLYEVACRASEALESIHPQ 1750
            .|.|    .|::||.|...:..|.:|...|:..::.:..||.|::.:|......:|:|:|.::.:
Mouse   968 FSLH----PEILSEEEATQMDQFGQAAGGLIHSIREIAQSHRAMEQELAHAVNASSKAMERVYGK 1028

  Fly  1751 GKLLEGPSLRTKLVEVIDSSRQLYDDACTLLRDRGHSLILREDLETKLSAALANMEMELKKCSVQ 1815
            .:..||.:. :.::|::::.|.|..:...||..: .:|.|....:.:|.|||..|:.:|:|.:..
Mouse  1029 PRTAEGLNC-SFVLEMVNNIRALRSETELLLAGK-MALQLDPPQKERLGAALIEMDQQLRKLTDT 1091

  Fly  1816 KCIDGKLRAYFNVLAPNEESDGRRK-SRPFWVRLRSGSTAGQQAFKPPLTN-TREAANN------ 1872
            ..:       ...|.|.||...::. ......|.|||.......||....| .:|..:|
Mouse  1092 PWL-------CQPLEPGEEESLQQNVMLDLTKRSRSGKFRLVTKFKKEKNNKNKEVHSNLGGPVH 1149

  Fly  1873 -WSVNEVVTWLETMQLSEYVDSFLKNDIRGKELLTLGRRDLKDL 1915
             |...||..|||.:.|.||.|.|.::||||.|||.|.|||||.|
Mouse  1150 LWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKVL 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34384	NP_001246971.1	PH	83..175	CDD:278594	49/91 (54%)
		PH_DGK_type2	84..180	CDD:270093	48/95 (51%)
		C1	196..245	CDD:197519	37/48 (77%)
		C1	268..318	CDD:197519	34/49 (69%)
		DAGKc	355..477	CDD:214487	100/121 (83%)
		DAGK_acc	1478..1635	CDD:279003	116/156 (74%)
		SAM_DGK-delta-eta	1869..1933	CDD:188906	26/54 (48%)
		SAM	1872..1935	CDD:197735	26/51 (51%)
Dgkd	XP_006529534.1	PH_DGK_type2	55..151	CDD:270093	48/95 (51%)
		C1	164..213	CDD:237996	37/48 (77%)
		C1	236..286	CDD:237996	34/49 (69%)
		DAGKc	323..445	CDD:214487	100/121 (83%)
		DAGKa	765..922	CDD:214486	116/156 (74%)
		SAM_superfamily	1147..>1193	CDD:387673	24/45 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846084
Domainoid	1	1.000	262	1.000	Domainoid score	I1935
eggNOG	1	0.900	-	-		E1_KOG1170
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1053	1.000	Inparanoid score	I258
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29151at33208
OrthoFinder	1	1.000	-	-		FOG0002628
OrthoInspector	1	1.000	-	-		otm42834
orthoMCL	1	0.900	-	-		OOG6_102702
Panther	1	1.100	-	-	O	PTHR11255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3373
SonicParanoid	1	1.000	-	-		X741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790