DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34384 and DGKH

DIOPT Version :9

Sequence 1:	NP_001246971.1	Gene:	CG34384 / 5740362	FlyBaseID:	FBgn0085413	Length:	1936	Species:	Drosophila melanogaster
Sequence 2:	NP_821077.1	Gene:	DGKH / 160851	HGNCID:	2854	Length:	1220	Species:	Homo sapiens

Alignment Length:	1967	Identity:	620/1967 - (31%)
Similarity:	818/1967 - (41%)	Gaps:	801/1967 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QRSPRGSRRSSPSSGRSSACSSGSISPVPIIPIISISHDGDESESESEIETEPARLFQRRMSTKC 76
            |..|.|: ....::|..:|.:|.:.|..|          |::| |:||.|.|..:...|::||..
Human     7 QHHPPGA-AGGAAAGAGAAVTSAAASAGP----------GEDS-SDSEAEQEGPQKLIRKVSTSG 59

  Fly    77 TNNLAAIIKEGFLLKHTWSFQRWRRRYFRLKRNMLFYAKDEKCDVFDDIDLSDLCYFECGIKNVN 141
            .......||||.|||.|.|||||::|||:|:...|:||||.|..:||::||||....|...||.|
Human    60 QIRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNAN 124

  Fly   142 HSFQIITPTRSLVLCAESRREMEDWLGSLKTATAPQRPRGDSFLIEQHDILSNHHHWYATSHARP 206
            :||.||||.|.|:||||:|:|||||:.|||:....:......|.:|.   .|..|:|||.|||||
Human   125 NSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEH---FSGMHNWYACSHARP 186

  Fly   207 TYCNVCRDALSGVTSHGLSCEVCKCKVHKRCAAKSIANCKWTTLASVGKDIIEQADGIIMPHQWM 271
            |:|||||::|||||||||||||||.|.|||||.::..|||||||||:||||||..||:.|||||:
Human   187 TFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWL 251

  Fly   272 EGNLPVSSMCAVCKKTCGSVLRLQDWRCLWCRATVHVACRPQMAVACPIGPAKLSVVPPTSVHSI 336
            |||||||:.||||.||||||||||||:||||:..||.||:......||:|..|:|::||.:::
Human   252 EGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQCKVSIIPPIALN-- 314

  Fly   337 STD-DAWDVASPKGNFSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLISTGPSLGLRLFRH 400
            ||| |.:..|:.....|||||||||||||||||||||||||||||||||||::.||.||||||:.
Human   315 STDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQK 379

  Fly   401 FEMFRILVCSGDGSVGWVLSEIDRFNMHKQCQVAVMPLGTGNDLARVLGWGSSCDDDTHLPQILE 465
            |:.||||||.|||||||||||||:.|::||||:.|:|||||||||||||||.|.||||.||||||
Human   380 FDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILE 444

  Fly   466 RYESASTKMLDRWSIMVFEKAIPVPKTPKMSI-----STEQEAMLTGMVTSANHHLRFIVETNDT 525
            :.|.||||||||||||.:|..:|    ||.|:     ...:|..:|....|...||..|:.:::.
Human   445 KLERASTKMLDRWSIMTYELKLP----PKASLLPGPPEASEEFYMTIYEDSVATHLTKILNSDEH 505

  Fly   526 QTLIRSTRNLCDTVDDLVCRISEHHKDD-------EQLAVKCDILRQKLNMLLDALQEEEIGAHS 583
            ..:|.|.:.||:||.|.|.::.:.:...       :.:|.||.:|.:||..||.||..:
Human   506 AVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVADAVASKCSVLNEKLEQLLQALHTD------ 564

  Fly   584 GDDLIATIRSLIARSIPVTPGSNAYLLNPNISIEKTEKDQINTKERRNSRSLRSSEKEA-----L 643
                        :::.||.||.:..::..:.....:|:....:||:......:.|.::|     :
Human   565 ------------SQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLGDDVTKPSSQKAVKPREI 617

  Fly   644 QCRANSVKRAIYNVVEHSEPGRPKRYQRKLSITPFEALKLPTASGESTPCTSPLPIIPPINIISP 708
            ..||||:|:|:..|:|.:
Human   618 MLRANSLKKAVRQVIEEA----------------------------------------------- 635

  Fly   709 TMETSRLTCISPLPDTRRDSVDENFFNSINLPAPRQFADSRRSSGVEVIQEIEEGANGETVYRKS 773

Human   636 ----------------------------------------------------------------- 635

  Fly   774 RMSLTGGANIDDAGNRLSPCSDAGENTPTERKVDFLRVPIHTGEPIVDPLCDYRPHEVFERTYYM 838
                  |..:||               ||
Human   636 ------GKVMDD---------------PT------------------------------------ 643

  Fly   839 TREMDKGKEKDKEKDKPVEIDKEKDTCVEKEGSMPAEKLVHTCNLQVPGVVVTPNPQNVYSSASI 903
                                                   ||.|           .|.|
Human   644 ---------------------------------------VHPC-----------EPAN------- 651

  Fly   904 TIIDTDAQTTTEQSSSDDLGGEASDVLSAISNEECSVASEIFDKQDAGQTVGDIIQNMDASNFTH 968
                         .|||
Human   652 -------------QSSD------------------------------------------------ 655

  Fly   969 IDSPETSDETEAMPGESIMDDISSVLGHDITYALQDNTLTDDTTTLCSEHAGPPKPPRKKSLSAL 1033
                                              .|:|.||:
Human   656 ----------------------------------YDSTETDE----------------------- 663

  Fly  1034 SRTQAHPRRRNSSPPRMARLARMDSDDNPQQFGFENIVFEIDNRCDDQKMREPPRYCSLAQFVEG 1098
            |:.:|                   .||.
Human   664 SKEEA-------------------KDDG------------------------------------- 672

  Fly  1099 NDIARQSFKQLMLEQHRGGDNDSDYPEHEQTPTNKGANLLATTSEDELSTQTAIKIEIQDIDATV 1163
               |::|.
Human   673 ---AKESI--------------------------------------------------------- 677

  Fly  1164 RNLNSSMKPNTILTTSTSPTKKSGHGQDVKRITFDESCKKESFDDVNPNYPQISVVVRPPTPLRG 1228
                      |:.|...||..::.:|.
Human   678 ----------TVKTAPRSPDARASYGH-------------------------------------- 694

  Fly  1229 DCIKPTVSLLPVSSGGAMTVSMTCSGMLGVRAMNASEIRRHSSHAPGLAVREFDKDKDRRHSGFN 1293
                                |.|.|                   .||.||
Human   695 --------------------SQTDS-------------------VPGPAV--------------- 705

  Fly  1294 PNQLTLDPEHARFLSSSPAASRRISCGSLFKKKNKKIGTKRSYGLFSVRFFVVAEPDFRLATLAL 1358
                              |||:
Human   706 ------------------AASK------------------------------------------- 709

  Fly  1359 IRPLIPLPNEALPNLQTLKGSKSSLFMGSTLFGFDHLASAEKDKEEKSGKDKEKTPTDETNRKLP 1423
                     |.||.|.|                                               .
Human   710 ---------ENLPVLNT-----------------------------------------------R 718

  Fly  1424 IINPLVRLPNWPNLANGGGFISKCLLANADTLCAAVSPLMDPDETLLAGYHEKCVMNNYFGIGID 1488
            ||.|.:|.....::| |...|:|.||||.|...|  :|.:|||...:.||.||||||||||||:|
Human   719 IICPGLRAGLAASIA-GSSIINKMLLANIDPFGA--TPFIDPDLDSVDGYSEKCVMNNYFGIGLD 780

  Fly  1489 AKISLDFHNKREEHPEKCRSRARNYMWYGVLGSKQLLQKTCKNLEQRVQLECDGQRIPLPELQGI 1553
            |||||:|:|||||||||||||.:|.|||||||:::|||::.||||||||||||||.||||.||||
Human   781 AKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGI 845

  Fly  1554 VILNIPSFMGGTNFWGSSKKDDIFLPPSFDDRVLEVVAVFGSVQMAASRLINLQHHRIAQCQSVQ 1618
            .:|||||:.|||||||.:|:||||..|||||::|||||:|.|:|||.||:|.|||||||||::|:
Human   846 AVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQHHRIAQCRTVK 910

  Fly  1619 INILGDEEIPIQVDGEAWLQPPGMIRILHKNRVQMLCRNRSLELSLKSWQEKQR----------- 1672
            |.|.|||.:|:|||||||:||||:|:|:||||.|||.|:|:.|.:||||::||:
Human   911 ITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDSGKPVLRTH 975

  Fly  1673 ---QHSISIQRDASSTASEHANSTDEVISERECYVLLNFIEAVSSLVKWVKFLIISHPALQHDLY 1734
               .|:|.:             :|:||...:.|      .:|...|:..:......|..|:.:|.
Human   976 LYIHHAIDL-------------ATEEVSQMQLC------SQAAEELITRICDAATIHCLLEQELA 1021

  Fly  1735 EVACRASEALESIHPQGKLLEGPSL-RTKLVEVIDSSRQLYDDACTLLRDRGHSLILREDLETKL 1798
            ......|.||...:|:..    .|| |....|:..:.:.||::..:||..| ..|.|....|.::
Human  1022 HAVNACSHALNKANPRCP----ESLTRDTATEIAINVKALYNETESLLVGR-VPLQLESPHEERV 1081

  Fly  1799 SAALANMEMELKKCSVQKCIDGKLRAYFNVLAPNEESD-----GRRKSRPFWVRL----RSGSTA 1854
            |.||.::|:||:|.:       ::...:.:|.|||:.:     .:|.:|....|:    :.....
Human  1082 SNALHSVEVELQKLT-------EIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQ 1139

  Fly  1855 GQQAFKPPLTNTREAANNWSVNEVVTWLETMQLSEYVDSFLKNDIRGKELLTLGRRDLKDLGVVK 1919
            .|:....|:       ..|...||..||:.:.|.||.|.|:::||||.|||.|.||||||||:.|
Human  1140 KQKTSSQPV-------QKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPK 1197

  Fly  1920 VGHVKRILQAIKDLSEN 1936
            |||||||||.||:|..:
Human  1198 VGHVKRILQGIKELGRS 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34384	NP_001246971.1	PH	83..175	CDD:278594	54/91 (59%)
		PH_DGK_type2	84..180	CDD:270093	54/95 (57%)
		C1	196..245	CDD:197519	36/48 (75%)
		C1	268..318	CDD:197519	34/49 (69%)
		DAGKc	355..477	CDD:214487	99/121 (82%)
		DAGK_acc	1478..1635	CDD:279003	117/156 (75%)
		SAM_DGK-delta-eta	1869..1933	CDD:188906	38/63 (60%)
		SAM	1872..1935	CDD:197735	39/62 (63%)
DGKH	NP_821077.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60		18/64 (28%)
		PH_DGK_type2	67..163	CDD:270093	54/95 (57%)
		PH	67..156	CDD:278594	54/88 (61%)
		C1	176..225	CDD:237996	36/48 (75%)
		C1	248..293	CDD:197519	34/44 (77%)
		DAGKc	334..456	CDD:214487	99/121 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..617		5/35 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..705		33/497 (7%)
		DAGKa	770..927	CDD:214486	117/156 (75%)
		SAM_DGK-eta	1147..1211	CDD:188975	39/70 (56%)
		SAM	1148..1211	CDD:197735	38/69 (55%)
		PDZ-binding	1218..1220
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155650
Domainoid	1	1.000	260	1.000	Domainoid score	I1984
eggNOG	1	0.900	-	-		E1_KOG1170
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H99373
Inparanoid	1	1.050	1050	1.000	Inparanoid score	I260
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29151at33208
OrthoFinder	1	1.000	-	-		FOG0002628
OrthoInspector	1	1.000	-	-		otm40760
orthoMCL	1	0.900	-	-		OOG6_102702
Panther	1	1.100	-	-	O	PTHR11255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3373
SonicParanoid	1	1.000	-	-		X741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790