Protein Alignment CG34384 and dgkh

DIOPT Version :10

• Sequence 1: NP_001246971.1
• Gene: CG34384 / 5740362
• FlyBaseID: FBgn0085413
• Length: 1936
• Species: Drosophila melanogaster
• Sequence 2: XP_009302858.2
• Gene: dgkh / 100137124
• ZFINID: ZDB-GENE-070912-328
• Length: 1306
• Species: Danio rerio
• Alignment Length: 2023
• Identity: 641/2023 - (31%)
• Similarity: 824/2023 - (40%)
• Gaps: 867/2023 - (42%)

  Fly    23 PSSGRSSACSSGSISPVPII----PIISISHDGDESESESEIETEPARLFQRRMSTKCTNNLAAI 83
            |.....:|.|:..:..|..:    |::      ||| |:||.|.|..:...|::||.........
Zfish    37 PQEPEKAAASASGVPAVGAVGGSGPVV------DES-SDSEGEQEGPQKLIRKVSTSGQIRSKTS 94

  Fly    84 IKEGFLLKHTWSFQRWRRRYFRLKRNMLFYAKDEKCD---------------------------- 120
            :|||.|||.|.|||||::|||:|:...|:||||.|..
Zfish    95 VKEGLLLKQTSSFQRWKKRYFKLRGRTLYYAKDAKAGGVLARWQYRVSRSRVCWRVLSVCWTGAR 159

  Fly   121 ---------------------VFDDIDLSDLCYFECGIKNVNHSFQIITPTRSLVLCAESRREME 164
                                 :||::||||....|...||:|:||.:|||.|.|:||||:|:|||
Zfish   160 RPPPALGASGSEEGLVAIRSLIFDEVDLSDASVAESSTKNINNSFTVITPFRRLILCAENRKEME 224

  Fly   165 DWLGSLKTATAPQRPRGDSFLIEQHDILSNHHHWYATSHARPTYCNVCRDALSGVTSHGLSCEVC 229
            ||:.|||:..:.:......|.:|.   .|..|:|||.||||||:||||||:||||||||||||||
Zfish   225 DWISSLKSVQSREHYETAQFNVEH---FSGMHNWYACSHARPTFCNVCRDSLSGVTSHGLSCEVC 286

  Fly   230 KCKVHKRCAAKSIANCKWTTLASVGKDIIEQADGIIMPHQWMEGNLPVSSMCAVCKKTCGSVLRL 294
            |.|.|||||.::..|||||||||:||||||..|||.|||||:|||||||:.||||.|||||||||
Zfish   287 KFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGIAMPHQWLEGNLPVSAKCAVCDKTCGSVLRL 351

  Fly   295 QDWRCLWCRATVHVACRPQMAVACPIGPAKLSVVPPTSVHSISTDDAWDVASPKGNFSPLLVFVN 359
            ||||||||:|.||.||.......||:|..|:|::|||:::||.:|..|....|....||||||||
Zfish   352 QDWRCLWCKAMVHTACMDLYPRKCPLGQCKVSIIPPTALNSIDSDGFWKATCPPSCASPLLVFVN 416

  Fly   360 SKSGDNQGVKFLRRFKQLLNPAQVFDLISTGPSLGLRLFRHFEMFRILVCSGDGSVGWVLSEIDR 424
            |||||||||||||||||||||||||||::.||.||||||:.|:.||||||.|||||||||||||:
Zfish   417 SKSGDNQGVKFLRRFKQLLNPAQVFDLVNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDK 481

  Fly   425 FNMHKQCQVAVMPLGTGNDLARVLGWGSSCDDDTHLPQILERYESASTKMLDRWSIMVFEKAIPV 489
            .|:|||||:.|:|||||||||||||||.||||||.||||||:.|.||||||||||||.:|..||
Zfish   482 LNLHKQCQLGVLPLGTGNDLARVLGWGPSCDDDTQLPQILEKLERASTKMLDRWSIMTYEIKIP- 545

  Fly   490 PKTPKMSI-STEQEA-----MLTGMVTSANHHLRFIVETNDTQTLIRSTRNLCDTVDDLVCRI-- 546
               ||.|. :|.:||     .::....|...||..|:.::....:|.|::.||:||.:.|.|:
Zfish   546 ---PKHSCPATPEEAEDGQLQISAYEDSVAAHLTKILNSDQHSVVISSSKVLCETVKEFVSRVGK 607

  Fly   547 -----SEHHKDDEQLAVKCDILRQKLNMLLDALQEEEIGAHSGDDLIATIRSLIARSIPVTPGSN 606
                 |:..::.:.||:||.:|.:||..||..|           :|.|.:.|..|
Zfish   608 CYERGSDSSEESDALALKCAMLNEKLESLLQTL-----------NLEAQVLSPTA---------- 651

  Fly   607 AYLLNPNISIEKTEKDQIN-----------TKERRNSRSLRSSEK-----EALQCRANSVKRAIY 655
              |..|.|..|:.|::::.           |:.:.|.....|:.|     |.|..||||:|:|:.
Zfish   652 --LTTPPIVEEEVEEEELEEEDEDLSEESLTELKENETEKGSAHKLFRPREQLVLRANSLKKALR 714

  Fly   656 NVVEHSEPGRPKRYQRKLSITPFEALKLPTASGESTPCTSPLPIIPPINIISPTMETSRLTCISP 720
            .::|.:|    :....:.:.|..:.|:.|:
Zfish   715 QIIEQAE----RMVDEQNAHTEEQELQSPS----------------------------------- 740

  Fly   721 LPDTRRDSVDENFFNSINLPAPRQFADSRRSSGVEVIQEIEEGANGETVYRKSRMSLTGGANIDD 785
              |.|:||.:||
Zfish   741 --DFRKDSEEEN----------------------------------------------------- 750

  Fly   786 AGNRLSPCSDAGENTPTERKVDFLRVPIHTGEPIVDPLCDYRPHEVFERTYYMTREMDKGKEKDK 850
                                                                          ||.
Zfish   751 --------------------------------------------------------------KDN 753

  Fly   851 EKDKPVEIDKEKDTCVEKEGSMPAEKLVHTCNLQVPGVVVTPNPQNVYSSASITIIDTDAQTTTE 915
            |||   |..||.:|       :|..|
Zfish   754 EKD---EDTKELET-------LPLAK--------------------------------------- 769

  Fly   916 QSSSDDLGGEASDVLSAISNEECSVASEIFDKQDAGQTVGDIIQNMDASNFTHIDSPETSDETEA 980
                                                                   ||
Zfish   770 -------------------------------------------------------SP-------- 771

  Fly   981 MPGESIMDDISSVLGHDITYALQDNTLTDDTTTLCSEHAGPPKPPRKKSLSALSRTQAHPRRRNS 1045
                                              ||       ||.:
Zfish   772 ----------------------------------CS-------PPER------------------ 777

  Fly  1046 SPPRMARLARMDSDDNPQQFGFENIVFEIDNRCDDQKMREPPRYCSLAQFVEGNDIARQSFKQLM 1110
                  |::|
Zfish   778 ------RISR------------------------------------------------------- 781

  Fly  1111 LEQHRGGDNDSDYPEHEQTPTNKGANLLATTSEDELSTQTAIKIEIQDIDATVRNLNSSMKPNTI 1175
                                                |||
Zfish   782 ------------------------------------STQ-------------------------- 784

  Fly  1176 LTTSTSPTKKSGHGQDVKRITFDESCKKESFDDVNPNYPQISVVVRPPTPLRGDCIKPTVSLLPV 1240
                                                                             
Zfish   785 ----------------------------------------------------------------- 784

  Fly  1241 SSGGAMTVSMTCSGMLGVRAMNASEIRRHSSHAPGLAVREFDKDKDRRHSGFNPNQLTLDPEHAR 1305
                                                                             
Zfish   785 ----------------------------------------------------------------- 784

  Fly  1306 FLSSSPAASRRISCGSLFKKKNKKIGTKRSYGLFSVRFFVVAEPDFRLATLALIRPLIPLPNEAL 1370
                        ||||                 ||:
Zfish   785 ------------SCGS-----------------FSI----------------------------- 791

  Fly  1371 PNLQTLKGSKSSLFMGSTLFGFDHLASAEKDKEEKSGKDKEKTPTDETNRKLPIINPLVRLPNW- 1434
                                                      ||...:...||::|..:..|..
Zfish   792 ------------------------------------------TPFTTSKENLPVLNTRIICPGLR 814

  Fly  1435 PNLA---NGGGFISKCLLANADTLCAAVSPLMDPDETLLAGYHEKCVMNNYFGIGIDAKISLDFH 1496
            ..||   .|...|||.||||.|...|  :|.:|||...|.||.||||||||||||:||||||:|:
Zfish   815 AGLAASIAGSSIISKMLLANIDPFGA--TPFIDPDLDSLEGYLEKCVMNNYFGIGLDAKISLEFN 877

  Fly  1497 NKREEHPEKCRSRARNYMWYGVLGSKQLLQKTCKNLEQRVQLECDGQRIPLPELQGIVILNIPSF 1561
            |||||||||||||.:|.|||||||:|:|||:|.|||||:||||||||.||||.||||.:|||||:
Zfish   878 NKREEHPEKCRSRTKNMMWYGVLGTKELLQRTYKNLEQKVQLECDGQYIPLPSLQGIAVLNIPSY 942

  Fly  1562 MGGTNFWGSSKKDDIFLPPSFDDRVLEVVAVFGSVQMAASRLINLQHHRIAQCQSVQINILGDEE 1626
            .|||||||.:|:||||..|||||::|||||||||:|||.||:|.|||||||||::|:|.|||||.
Zfish   943 AGGTNFWGGTKEDDIFCAPSFDDKILEVVAVFGSMQMAVSRVIKLQHHRIAQCRTVKITILGDEG 1007

  Fly  1627 IPIQVDGEAWLQPPGMIRILHKNRVQMLCRNRSLELSLKSWQEKQR------------QHSISIQ 1679
            :|:|||||||:||||:|:|.||||.|||.|:|:.|.:||||::|.:            |.|:.:.
Zfish  1008 VPVQVDGEAWIQPPGVIKIQHKNRAQMLTRDRAFENTLKSWEDKLKYDKPPLRPHLYPQQSVDLA 1072

  Fly  1680 RDASSTASEHANSTDEVISERECYVLLNFIEAVSSLVKWVKFLIISHPALQHDLYEVACRASEAL 1744
            .:..:|..:......|.:..|.|....|:                  ..|:.:|......:|.|:
Zfish  1073 TEEEATLIQMCARAAEDLITRICEAAKNY------------------QLLEQELAHAVNASSHAI 1119

  Fly  1745 ESIHPQGKLLEGPSLRTKLVEVIDSSRQLYDDACTLLRDRGHSLILREDLETKLSAALANMEMEL 1809
            ...||  |..|..: |...:||..:.:.|:::..:||..| ..|.|....|..||.||.|:|:||
Zfish  1120 NKTHP--KFPESLT-RNTAIEVASTVKALHNETESLLVGR-VPLQLDPPHEELLSTALQNVEVEL 1180

  Fly  1810 KKCSVQKCIDGKLRA---YFNVLAPNEESD-----GRRKSRPFWVRLRSGSTAGQQAFKP---PL 1863
                      |||..   .:::|.||:|.|     |:|.|       |||.......||.   |.
Zfish  1181 ----------GKLVEIPWLYHILQPNDEEDPSLEYGKRNS-------RSGMFRIVPKFKKEKVPK 1228

  Fly  1864 TNTREAANNWSVNEVVTWLETMQLSEYVDSFLKNDIRGKELLTLGRRDLKDLGVVKVGHVKRILQ 1928
            .::.::...|...||..|||.:.|.||.|:|:::||||.|||.|.||||||||:.||||:|||||
Zfish  1229 KSSPQSVQRWGTEEVAIWLEQLSLGEYKDTFIRHDIRGSELLHLERRDLKDLGISKVGHMKRILQ 1293

  Fly  1929 AIKDLSEN 1936
            ..|||:::
Zfish  1294 GTKDLAKS 1301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34384	NP_001246971.1	PH_DGK_type2	84..180	CDD:270093	52/144 (36%)
		C1_DGK_typeII_rpt1	192..251	CDD:410350	44/58 (76%)
		C1_DGK_typeII_rpt2	268..321	CDD:410402	38/52 (73%)
		DAGKc	355..477	CDD:214487	101/121 (83%)
		DAGKa	1478..1635	CDD:214486	121/156 (78%)
		SAM_DGK-delta-eta	1869..1933	CDD:188906	37/63 (59%)
dgkh	XP_009302858.2	None