DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spok and CYP78A6

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_182189.1	Gene:	CYP78A6 / 819278	AraportID:	AT2G46660	Length:	530	Species:	Arabidopsis thaliana

Alignment Length:	577	Identity:	142/577 - (24%)
Similarity:	233/577 - (40%)	Gaps:	111/577 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TSVFYVLFAIAITIILISYVFLLLKCKQKAF--VVIGLLYQEKKYQCFDQAPGPHPWPIIGNINL 65
            |::.:.|.|:.|..:.|| :||.......|:  .:.|.|. ...|:..:..|||..:|::|:::|
plant    23 TNLAFSLLAVTIIWLAIS-LFLWTYPGGPAWGKYLFGRLI-SGSYKTGNVIPGPKGFPLVGSMSL 85

  Fly    66 LGRFQYNPFYGFGTL--------TKKYG--DIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGR 120
            :.          .||        .:|:|  .:.:.|||.||.||..|.|:.||:|  |...|..|
plant    86 MS----------STLAHRRIADAAEKFGAKRLMAFSLGETRVIVTCNPDVAKEIL--NSPVFADR 138

  Fly   121 P-DFFRYHKLFGGDRNNSLALCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQ 184
            | ....|..:|    |.::.........:..|.:|..|..   |:....:......:..:|:::.
plant   139 PVKESAYSLMF----NRAIGFAPHGVYWRTLRRIASNHLF---STKQIRRAETQRRVISSQMVEF 196

  Fly   185 LTNISSGYPCDVKPLILAASANMFCQYMCSVRFNYS---DKGFQKIIEYFDEIFWEINQGYSF-- 244
            |...||..||.|:.|:..||.|   ..|||| |...   :|...::.|..:|       ||..
plant   197 LEKQSSNEPCFVRELLKTASLN---NMMCSV-FGQEYELEKNHVELREMVEE-------GYDLLG 250

  Fly   245 -----DYIPWLVPFYCNHI-SRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKE 303
                 |::|||..|....: ||.......:.:|:...|..||...   .:..:||.|.||.....
plant   251 TLNWTDHLPWLSEFDPQRLRSRCSTLVPKVNRFVSRIISEHRNQT---GDLPRDFVDVLLSLHGS 312

  Fly   304 DKNVSRNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMN 368
            ||....:.|..:.|....|...|..|:...||.:..:|.:...::||:|.|..|. |.:...|:.
plant   313 DKLSDPDIIAVLWEMIFRGTDTVAVLIEWILARMVLHPDMQSTVQNELDQVVGKS-RALDESDLA 376

  Fly   369 VMPYTMASISEVLR-YSSSPIV--PHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQF 430
            .:||..|.:.|||| :...|::  ..:|:.||::.|..|..||...:|.:.::.....|..|.:|
plant   377 SLPYLTAVVKEVLRLHPPGPLLSWARLAITDTIVDGRLVPAGTTAMVNMWAVSHDPHVWVDPLEF 441

  Fly   431 DPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSV 495
            .||||:.                          .:|..:....|           |..:..||..
plant   442 KPERFVA--------------------------KEGEVEFSVLG-----------SDLRLAPFGS 469

  Fly   496 GKRTCIGQSLVRGFGFLLL--ANIIQNYNVNSADFSKIKL-EKSSIA------LPKK 543
            |:|.|.|::|  ||..::.  |.::..:....:|.:.:.| ||..::      ||.|
plant   470 GRRICPGKNL--GFTTVMFWTAMMLHEFEWGPSDGNGVDLSEKLRLSCEMANPLPAK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	130/526 (25%)
CYP78A6	NP_182189.1	p450	25..523	CDD:386267	139/572 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000