Protein Alignment spok and cyp21a2

DIOPT Version :10

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_021330030.1
• Gene: cyp21a2 / 793249
• ZFINID: ZDB-GENE-070103-6
• Length: 522
• Species: Danio rerio
• Alignment Length: 584
• Identity: 135/584 - (23%)
• Similarity: 234/584 - (40%)
• Gaps: 114/584 - (19%)

  Fly    14 ITIILISYVFLLLKCK---QKAFVVIGLLYQEKK------------YQCF-----DQAPGPHPWP 58
            ::::|:.::..:|..|   |......|:..:..|            |:.|     ....||...|
Zfish     6 VSVVLLLFILWMLVVKFRRQSHRRTDGVAKENNKPEAVFPKLLHSLYKLFFSTVSPTISGPRSLP 70

  Fly    59 IIGNINLLGRFQYNPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDF 123
            ::||:..|.: .:.|.: ...|.|.||:||.|:.|.|..:|:||.::|:|.|.|....|.|||..
Zfish    71 LLGNMLDLAQ-DHLPIH-LTALAKCYGNIYRLNCGSTTMVVLNNSEIIREALVKKWSDFAGRPHS 133

  Fly   124 FRYHKLFGGDRNNSLALCDWSQLQQKRRNL---ARRHCSPRESSSYFSKMSEIGGLEVNQLLDQL 185
            :....:..|.|  :::|.|:|:..:..|.:   |.:.|:.....|...|.:        |.|.|:
Zfish   134 YTGDIVSRGGR--TISLGDFSEEWKAHRRVTHSALQRCTTDSLHSVIEKQA--------QHLCQV 188

  Fly   186 TNISSGYPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEI--FWEINQGYSFDYIP 248
            ....||...|:......||:|:......|..::.|....||:.|..:||  .|......:.|..|
Zfish   189 LRDYSGKAVDLSEDFTVASSNVITTLTFSKAYDKSSAELQKLQECLNEIVSLWGSPWISALDSFP 253

  Fly   249 WLVPFYCNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKNVSRNTII 313
            .|..|.....||::...|...:.|.:.|...::|.   ::.....|.:|||.|:..:..:.:|.:
Zfish   254 LLRKFPNPPFSRLMKEVARRDELIGKHIEEFKKSE---HKEGGTLTSSLLKCLEPQQGAANHTTL 315

  Fly   314 -------FMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDM---- 367
                   ..::..|||...:..|:...:|::...|.:...:..|:          .|:.|:
Zfish   316 TDTHVHMTTVDLLIGGTETIAALLNWTVAFLLHRPEVQDKVYEEL----------CCMLDVRHPQ 370

  Fly   368 ----NVMPYTMASISEVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNH 426
                :.:||..|.|||:||... :|: |||.|:.::.|.|..:.|.||:..|.|..:.....|:.
Zfish   371 YSDRHKLPYLCALISEMLRLRPVAPLAVPHRAIRNSSIAGHFIPKNTIIIPNLYGAHHDPEVWDD 435

  Fly   427 PEQFDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFL 491
            |..|.||||||.                         ..||.:|                   .:
Zfish   436 PYSFKPERFLEG-------------------------GGGSLRS-------------------LI 456

  Fly   492 PFSVGKRTCIGQSLVRGFGFLLLANIIQNYNVNSADFSKIKLE---KSSIALPKKCFKLSLRPR 552
            ||..|.|.|:|:::.:...||..|.:::.:....|...:...|   .:|:.|..|.:.:...||
Zfish   457 PFGGGARLCLGEAVAKMEMFLFTAYLLREFKFLPASKEEPLPELRGVASVVLKVKPYTVIAHPR 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	CYP1_2-like	85..547	CDD:410710	115/486 (24%)
cyp21a2	XP_021330030.1	cytochrome_P450	94..516	CDD:477761	116/488 (24%)