DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spok and Cyp2b15

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001129140.1	Gene:	Cyp2b15 / 685222	RGDID:	1596474	Length:	495	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	139/573 - (24%)
Similarity:	236/573 - (41%)	Gaps:	127/573 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IILISYV--FLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNPFYGFG 78
            ::|:::.  ||||...|......|.|           .|||.|.|.:||:..:.|  ......|.
  Rat     6 LLLLTFTVGFLLLLASQNRPKTHGHL-----------PPGPRPLPFLGNLLQMNR--RGLLRSFM 57

  Fly    79 TLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGR-------PDFFRYHKLF-GGDRN 135
            .|.:||||::::.||....:::...|.|:|.|....:.|.||       |....|..:| .|:|
  Rat    58 QLQEKYGDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTVAVLHPVVQGYGVIFANGER- 121

  Fly   136 NSLALCDWSQLQQ----KRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDV 196
                   |..|::    ..||......|..|      ::.|    |...|:::|... .|...:.
  Rat   122 -------WKILRRFSLVTMRNFGMGKRSVEE------RIKE----EAQCLVEELKKY-KGALLNP 168

  Fly   197 KPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIF----------WEINQGYSFDYIPWLV 251
            ..:..:.:||:.|..:...||:|.|..|.::::...:.|          :|:..|: ..|.|.:.
  Rat   169 TSIFQSIAANIICSIVFGERFDYKDHQFLRLLDLIYQTFSLMGSLSSQVFELFSGF-LKYFPGVH 232

  Fly   252 PFYCNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKN------VSRN 310
            .....::..|:::        ::..|....:.::.|.| :||.:..|..::::|:      ..:|
  Rat   233 KQISKNLQEILNY--------IDHSVEKHRATLDPNTP-RDFINTYLLRMEKEKSNHHTEFHHQN 288

  Fly   311 TIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRI-CLYDMNVMPYTM 374
            .:|.:|..|..|.......:..:...:.|.|.:|..::.|:|.|.  |..|: .|.|...||||.
  Rat   289 LVISVLSLFFTGTETTSTTLRYSFLIMLKYPHVAEKVQKEIDQVI--GSHRLPTLDDRTKMPYTD 351

  Fly   375 ASISEVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVF-INNYVLNMSESFWNHPEQFDPERFL 436
            |.|.|:.|::. .|| :||....||:..|:.:.|.|.|: |.:..|: ...:::||:.|:||.||
  Rat   352 AVIHEIQRFADLIPIGLPHRVTNDTMFLGYLLPKNTEVYPILSSALH-DPRYFDHPDTFNPEHFL 415

  Fly   437 ENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCI 501
            :.|.|                                         |||| ..|||||.|||.|:
  Rat   416 DVNGT-----------------------------------------LKKS-EAFLPFSTGKRICL 438

  Fly   502 GQSLVRGFGFLLLANIIQNYNVNS------ADFSKIKLEKSSIALPKKCFKLS 548
            |:.:.:...|:....|:||:::.|      .|.|.|....|.|..|.:...||
  Rat   439 GEGIAQNELFIFFTAILQNFSLASPVAPEDIDLSPINSGISKIPSPYQIHFLS 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	131/535 (24%)
Cyp2b15	NP_001129140.1	p450	32..487	CDD:278495	129/530 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010