DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2ab1

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_017453675.1	Gene:	Cyp2ab1 / 679979	RGDID:	1586963	Length:	494	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	125/516 - (24%)
Similarity:	202/516 - (39%)	Gaps:	120/516 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRP--DFFRYHKLFGGDR---NNSLA 139
            |.:.:|:::::.||.|..:|:|....:||.|..|.:.|.|||  .|||  .|||...   :|.|.
  Rat    54 LAQTHGNVFTVWLGSTPIVVLNGFRAVKEALVSNSEQFSGRPLTPFFR--DLFGEKGVICSNGLT 116

  Fly   140 LCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIG-GLEVNQL--------LDQLTNISSGYPCD 195
               |.|        .||.|        .:.:.|:| |.:..:|        |.::.:...|...|
  Rat   117 ---WRQ--------QRRFC--------LTTLRELGLGKQALELQLQHEAAELAEVFHQEQGRAFD 162

  Fly   196 VKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSF---------DYIPWLV 251
            .:..|:.::..:....:....|...:..|.::|.       .||.|.:|         |..||.:
  Rat   163 PQVPIIRSTTRVIGALVFGHHFLSEEPIFLELIR-------AINLGLAFASTTWRRLYDMFPWAL 220

  Fly   252 PFYCNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKE--DKNVS----RN 310
            .:......:|..:..::|.||...|:.|:   :...|..|||....|..:.:  |..||    .|
  Rat   221 RYLSGPHQKIFQYHEAVRGFIHHEIIRHK---LRTPEAPKDFISCYLSQITKAMDDPVSTFSEEN 282

  Fly   311 TIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMA 375
            .|..:::.|:||.......:..|:.|:..:..|...::.|:|.|.... :.:|..|...:|||.|
  Rat   283 LIQVVIDLFLGGTDTTATTLHWAIIYLVHHRAIQERVQQELDEVLGTA-QAVCYEDRERLPYTRA 346

  Fly   376 SISEVLRYSSSPIVPHV--AMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFLEN 438
            .:.||.|.||...|..|  .:..|.:.|:.|.||||:..|...:......|..|.||:|..||
  Rat   347 VLHEVQRLSSVVAVGAVRQCVTPTWMHGYYVSKGTIILPNLASVLCDPECWETPHQFNPGHFL-- 409

  Fly   439 NFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQ 503
                                    |.||...:.:                .|||||.|.|.|.|:
  Rat   410 ------------------------DKDGDFVTNE----------------AFLPFSAGHRVCPGE 434

  Fly   504 SLVRGFGFLLLANIIQNYNVNSADFSK-IKLE-----------KSSIALPKKCFKLSLRPR 552
            .|.|...||:.|.:::.:.....:.|: ::||           :...|:|:..   ||.||
  Rat   435 QLARMELFLMFATLLRTFRFQLPEGSQGLRLEYVFGGTLQPQPQKICAVPRLS---SLSPR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	121/511 (24%)
Cyp2ab1	XP_017453675.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010