DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2f4

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_062176.1	Gene:	Cyp2f4 / 54246	RGDID:	2476	Length:	491	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	154/573 - (26%)
Similarity:	245/573 - (42%)	Gaps:	121/573 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNPFYGF 77
            ||.::|::.:.|.|     .|...|      |.|.   .|||.|.||:|  |||.....:.....
  Rat     7 AILLLLLAVISLSL-----TFTSWG------KGQL---PPGPKPLPILG--NLLQLRSQDLLTSL 55

  Fly    78 GTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGR---PDFFRYHKLFGGDRNNSLA 139
            ..|:|.||.::::.||..|.||::....:||.|...|:.|.||   |.||.:.|      .|.:|
  Rat    56 TKLSKDYGSVFTVYLGPRRVIVLSGYQTVKEALVDKGEEFSGRGSYPIFFNFTK------GNGIA 114

  Fly   140 LCD---WSQLQ----QKRRN--LARRHCSPR--ESSSYFSKMSEIGGLEVNQLLDQLTNISSGYP 193
            ..|   |..|:    |..||  :.:|....|  |..|:              |||.|.. :.|.|
  Rat   115 FSDGERWKILRRFSVQILRNFGMGKRSIEERILEEGSF--------------LLDVLRK-TEGKP 164

  Fly   194 CDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIF------WEINQGYSFDYIPWLVP 252
            .|...::..:.:|:.|..:...||:|.|:....||.:.::.|      |    |..::..|.|:.
  Rat   165 FDPVFILSRSVSNIICSVIFGSRFDYDDERLLTIIHFINDNFQIMSSPW----GEMYNIFPSLLD 225

  Fly   253 FYCNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDK-----NVSRNTI 312
            :......|:......::..|...:..|::| ::.|.| :||.|..|..:.::|     :.:.:|:
  Rat   226 WVPGPHRRVFRNFGGMKDLIARSVREHQDS-LDPNSP-RDFIDCFLTKMVQEKQDPLSHFNMDTL 288

  Fly   313 IFMLEDFI-GGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMAS 376
            :....:.: ||...||..:..|...:.|.|.:...::.|:|.|..:. |...|.|...||||.|.
  Rat   289 LMTTHNLLFGGTETVGTTLRHAFLILMKYPKVQARVQEEIDCVVGRS-RMPTLEDRASMPYTDAV 352

  Fly   377 ISEVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGT-IVFINNYVLNMSESFWNHPEQFDPERFLEN 438
            |.||.|::. .|: :||..:.||..:||.:.||| ::.:.|.|...|:.| ..|::|:||.||:
  Rat   353 IHEVQRFADVIPMNLPHRVIRDTPFRGFLIPKGTDVITLLNTVHYDSDQF-KTPQEFNPEHFLD- 415

  Fly   439 NFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQ 503
                                                    .|:..||| |.|:|||.|:|.|:|:
  Rat   416 ----------------------------------------ANQSFKKS-PAFMPFSAGRRLCLGE 439

  Fly   504 SLVRGFGFLLLANIIQNYN----VNSADFSKIKLEKSSIALPKKCFKLSLRPR 552
            .|.|...|:.|.:|:||:.    |...|.....|......||:. |:|.:|.|
  Rat   440 PLARMELFIYLTSILQNFTLHPLVEPEDIDLTPLSSGLGNLPRP-FQLCMRIR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	143/529 (27%)
Cyp2f4	NP_062176.1	p450	31..488	CDD:278495	143/530 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920