DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spok and Cyp305a1

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	132/583 - (22%)
Similarity:	226/583 - (38%)	Gaps:	119/583 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLFAIAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYN 72
            ::|..||.|               .||:..|:...::.:.|  .|||...|.:|| .|..|.:.:
  Fly     4 LIFLCAILI---------------GFVIYSLISSARRPKNF--PPGPRFVPWLGN-TLQFRKEAS 50

  Fly    73 PFYGFGTLTKKY-----GDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGG 132
            ...|...|.:::     .|:..|.||....:|....:::|||  :..:.|.||||.|.......|
  Fly    51 AVGGQHILFERWAKDFRSDLVGLKLGREYVVVALGHEMVKEV--QLQEVFEGRPDNFFLRLRTMG 113

  Fly   133 DRNNSLALCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDVK 197
            .|..  ..|...||..:.|:.|.:..  |......|:|.....||..:||.||......   .::
  Fly   114 TRKG--ITCTDGQLWYEHRHFAMKQM--RNVGYGRSQMEHHIELEAEELLGQLERTEEQ---PIE 171

  Fly   198 PLILAASA--NMFCQYMCSVRFNYSDKG-FQKIIEYFD---EIFWEINQGYSFDYIPWLVPFYCN 256
            |:...|.:  |:....:...|....:.| .:::::..:   ::| :|..|....: |||     .
  Fly   172 PVTWLAQSVLNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLF-DICGGLLAQF-PWL-----R 229

  Fly   257 HI-------SRIVHWSASIRKFILERIVNHRESNININEP-DKDFTDALLKSLKE-----DKNVS 308
            |:       :.|...:..:..|.::.|..||........| :.|...|.|:.:|:     :.:..
  Fly   230 HVAPDRTGYNLIQQLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTF 294

  Fly   309 RNT--IIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVD-TVSAKGI-------RRIC 363
            ..|  ::.:|:.||.|.....|.:.|||..:|..|.:...:.::|. :|:|...       ||
  Fly   295 NETQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRR-- 357

  Fly   364 LYDMNVMPYTMASISEVLR-YSSSPIV-PHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNH 426
                ....|..|.|.||.| :..:||. |..|:..|.:.|:.:.|...:.|:...:::.:..|..
  Fly   358 ----EAFDYMDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKD 418

  Fly   427 PEQFDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFL 491
            |.:|.||||:                          |:.|.....:|                |:
  Fly   419 PLEFRPERFI--------------------------DSAGKCFKDEY----------------FM 441

  Fly   492 PFSVGKRTCIGQSLVRGFGFLLLANIIQNYN-VNSADFSKIKLEKSSIALPKKCFKLSLRPRT 553
            ||.:|:|.|:|.:|.|...|..|..|:|::: |..|..|...:....|.|..|.:|:....||
  Fly   442 PFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTPKPYKVQFVKRT 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	122/533 (23%)
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	122/534 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469056
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24303
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
	3	3.030