DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spok and Cyp2c7

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_058854.1	Gene:	Cyp2c7 / 29298	RGDID:	620379	Length:	490	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	148/578 - (25%)
Similarity:	237/578 - (41%)	Gaps:	143/578 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNI------NL---LGRFQYNP 73
            |::::.|.|    .:.:::.|..|..:.:  ...|||.|.|||||.      |:   |.:|
  Rat     3 LVTFLVLTL----SSLILLSLWRQSSRRR--KLPPGPTPLPIIGNFLQIDVKNISQSLTKF---- 57

  Fly    74 FYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGR---PDFFRYHKLFG---- 131
                   :|.||.:::|.||....::::..:.|||.|..||:.|.||   |......|.||
  Rat    58 -------SKTYGPVFTLYLGSQPTVILHGYEAIKEALIDNGEKFSGRGSYPMNENVTKGFGIVFS 115

  Fly   132 -GDRNNSLALCDWSQLQQ----KRRNL--ARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNIS 189
             |:|        |.::::    ..|||  .:|:...|...            |...|:::|.. :
  Rat   116 NGNR--------WKEMRRFTIMNFRNLGIGKRNIEDRVQE------------EAQCLVEELRK-T 159

  Fly   190 SGYPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFY 254
            .|.|||...::..|..|:.|.......|:|.||.....:|       ::|:.......||:.  .
  Rat   160 KGSPCDPSLILNCAPCNVICSITFQNHFDYKDKEMLTFME-------KVNENLKIMSSPWMQ--V 215

  Fly   255 CNHISRIVHWSAS-----------IRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKNV- 307
            ||....::.:...           ::.::|::|..|:|| :::..| :||.|..|...|:..|:
  Rat   216 CNSFPSLIDYFPGTHHKIAKNINYMKSYLLKKIEEHQES-LDVTNP-RDFVDYYLIKQKQANNIE 278

  Fly   308 ----SRNTIIFMLEDFIG-GHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDM 367
                |...:...:.|.|| |...:...:..||..:.|.|.:...::.|:|.|..:. |..|:.|.
  Rat   279 QSEYSHENLTCSIMDLIGAGTETMSTTLRYALLLLMKYPHVTAKVQEEIDRVIGRH-RSPCMQDR 342

  Fly   368 NVMPYTMASISEVLRYSS--SPIVPHVAMEDTVIKGFGVRKGTIVFIN-NYVLNMSESFWNHPEQ 429
            ..||||.|.|.||.|:.:  ...:||....|...:.:.:.|||.|..: ..||:.|:.|.| ||.
  Rat   343 KHMPYTDAMIHEVQRFINFVPTNLPHAVTCDIKFRNYLIPKGTKVLTSLTSVLHDSKEFPN-PEM 406

  Fly   430 FDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFS 494
            |||..||:.|                          |:.|...|                |||||
  Rat   407 FDPGHFLDEN--------------------------GNFKKSDY----------------FLPFS 429

  Fly   495 VGKRTCIGQSLVRGFGFLLLANIIQNYNVNS----ADFSKIKLEKSSIALP---KKCF 545
            .|||.|:|:.|.|...||.|..|:||:|:.|    .|...:.:.....:||   :.||
  Rat   430 AGKRACVGEGLARMQLFLFLTTILQNFNLKSLVHPKDIDTMPVLNGFASLPPTYQLCF 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	143/544 (26%)
Cyp2c7	NP_058854.1	p450	30..487	CDD:278495	141/543 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920