DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2b21

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_942028.1	Gene:	Cyp2b21 / 292728	RGDID:	735174	Length:	494	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	141/546 - (25%)
Similarity:	231/546 - (42%)	Gaps:	119/546 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLFAIAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYN 72
            :|||     :|..::.||::.:...:   |.|           .|||.|.|::||:..:.|  ..
  Rat     7 LLFA-----LLTGFLLLLIRGQGNGY---GHL-----------PPGPCPLPLLGNVLQMDR--RG 50

  Fly    73 PFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGR-------PDFFRYHKLF 130
            ....|..|..||||:.::.||....:::...:.|:|.|..:.:.|.||       |....|..:|
  Rat    51 LLKSFIQLRDKYGDVVTVHLGPRPIVMLYGTETIREALVDHAEAFSGRGTVAVVQPIIQDYGMIF 115

  Fly   131 -GGDRNNSLALCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPC 194
             .|:|        |..|  :|.:||..........|...::.|    |...|:::|... .|.|.
  Rat   116 ANGER--------WKIL--RRFSLATMRDFGMGKRSVEERIKE----EAQCLVEELKKY-KGAPL 165

  Fly   195 DVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIF----------WEINQGYSFDYIPW 249
            |....:...:||:.|..:...||:|:|..|..:::.|.||.          :|:..|: ..|.|.
  Rat   166 DPTFHLQCITANIICSIVFGERFDYTDHQFLHLLDLFYEILSLVSSFSSQVFELFTGF-LKYFPG 229

  Fly   250 LVPFYCNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDA-LLKSLKEDKN-----VS 308
            .    ..|||:.:.   .|..||...:..|| :.::.:.| :||.|. ||:..||..|     ..
  Rat   230 T----HRHISKNIE---EILNFIGHCVEKHR-ATLDPSTP-RDFIDTYLLRMEKEKLNHHTEFHH 285

  Fly   309 RNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNV-MPY 372
            :|.::.:|..|..|.......:......:.|.|.:|..::.|:|.|.  |..|:...|..: |||
  Rat   286 QNLMMSVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVI--GSHRVPTLDDRIKMPY 348

  Fly   373 TMASISEVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVF-INNYVLNMSESFWNHPEQFDPER 434
            |.|.|.|:.|:|. .|| :||...:||:.:|:.:.|...|: |.:..|: ...::.||:.|:||.
  Rat   349 TDAVIHEIQRFSDLVPIGLPHRVTKDTLFRGYLLPKNIEVYPILSSALH-DPQYFEHPDTFNPEH 412

  Fly   435 FLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRT 499
            ||:.|..                 ::||:                         .|||||.|||.
  Rat   413 FLDANGA-----------------LKKNE-------------------------AFLPFSTGKRV 435

  Fly   500 CIGQSLVRGFGFLLLANIIQNYNVNS 525
            |:|:.:.|...||....|:||::|:|
  Rat   436 CLGEGIARNELFLFFTTILQNFSVSS 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	133/502 (26%)
Cyp2b21	NP_942028.1	p450	42..488	CDD:278495	127/492 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010