DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spok and Cyp2w1

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_038945900.1	Gene:	Cyp2w1 / 288517	RGDID:	1305193	Length:	492	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	117/489 - (23%)
Similarity:	204/489 - (41%)	Gaps:	83/489 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PGPHPWPIIGNINLLGRFQYNPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKY 116
            |||.|.|.:||::|||....:  .....|:::||.::::.||..:.:|::..::::|.|...|..
  Rat    36 PGPRPLPFLGNLHLLGVTHQD--RALMELSERYGPMFTIHLGSQKTVVLSGYEVVREALVGTGHE 98

  Fly   117 FGGRP--DFFRYHKLFGGDRNNSLALCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIGGLEVN 179
            ...||  ..|:..:..||...:|..  .|.         ..|..:.|...|...:...:.|..:.
  Rat    99 LADRPPIPIFQLIQRGGGIFFSSGV--HWK---------VARQFTVRTLQSLGIRQPPMVGKVLQ 152

  Fly   180 QLLDQLTNISS--GYPCDVKPLILA--ASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEI-N 239
            :|:.....:.|  |.|.   ||.|.  |..|:....:...||:|.|..|..::...|::...: :
  Rat   153 ELVCLKGQLDSYGGQPF---PLTLLGWAPCNITFTLLFGQRFDYQDPVFVSLLSLIDQVMVLLGS 214

  Fly   240 QGYS-FDYIPWLVPFYCNH---ISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKS 300
            .|.. |:..|.|......|   :|:|    ..:|. ||..::..:...:....|.:.:.:|||:.
  Rat   215 PGIQLFNTFPRLGALLRLHRPVLSKI----EEVRT-ILRTLLEAQRPPLPNGSPARSYVEALLQQ 274

  Fly   301 LK---EDKNVSRNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRI 362
            .:   ||.....|.:...|:..:.|.......:..|:..:.|:|.:...::.|:|.|...| :..
  Rat   275 GQDDPEDMFSEANVLACTLDMVMAGTETTAATLQWAVFLMVKHPHVQGRVQEELDRVLGPG-QLP 338

  Fly   363 CLYDMNVMPYTMASISEVLRY-SSSPIVPHVAMEDTVIKGFGVRKGT--IVFINNYVLNMSESFW 424
            ...|...:|||.|.:.||.|| :..|.||.....|..:.|:.:.|||  |..:.:.:|:.::  |
  Rat   339 QPEDQRALPYTSAVLHEVQRYITLLPHVPRCTAADIQLGGYLLPKGTPVIPLLTSVLLDKTQ--W 401

  Fly   425 NHPEQFDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQ 489
            ..|.||:|..||:         ...|       |:::.                          .
  Rat   402 ETPSQFNPNHFLD---------AKGC-------FMKRG--------------------------A 424

  Fly   490 FLPFSVGKRTCIGQSLVRGFGFLLLANIIQNYNV 523
            |||||.|:|.|:|:||.|...|||.|.::|.|::
  Rat   425 FLPFSTGRRVCVGESLARTELFLLFAGLLQQYHL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	117/489 (24%)
Cyp2w1	XP_038945900.1	cytochrome_P450	66..486	CDD:425388	106/457 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920