DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2d5

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_775426.1	Gene:	Cyp2d5 / 286963	RGDID:	628630	Length:	504	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	113/532 - (21%)
Similarity:	218/532 - (40%)	Gaps:	104/532 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNPF---YGFGT 79
            :.:.:|:||         :.|:::.:::.. ...|||.|||::||:     .|.:|.   |....
  Rat    14 IFTVIFILL---------VDLMHRHQRWTS-RYPPGPVPWPVLGNL-----LQVDPSNMPYSMYK 63

  Fly    80 LTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSLALCDWS 144
            |..:|||::||.:|....::||.:..::|||..:|:....||....:..|....|:..:....:.
  Rat    64 LQHRYGDVFSLQMGWKPMVIVNRLKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQGVVFASYG 128

  Fly   145 -QLQQKRR----NLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDVKPLILAAS 204
             :.:::||    .|.......:....:.:|       |...|.|..| ..:|...:.|.::..|.
  Rat   129 PEWREQRRFSVSTLRTFGMGKKSLEEWVTK-------EAGHLCDAFT-AQNGRSINPKAMLNKAL 185

  Fly   205 ANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWL---------VPFYCNHISR 260
            .|:....:.:.||.|.|....:::...:|...|::     .:||.:         :|...:   :
  Rat   186 CNVIASLIFARRFEYEDPYLIRMLTLVEESLIEVS-----GFIPEVLNTFPALLRIPGLAD---K 242

  Fly   261 IVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKN------VSRNTIIFMLEDF 319
            :.....:...| |:.::....:..:..:|.::.|||.|..:::.|.      ...|..:.:::.|
  Rat   243 VFQGQKTFMAF-LDNLLAENRTTWDPAQPPRNLTDAFLAEVEKAKGNPESSFNDENLRMVVVDLF 306

  Fly   320 IGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASISEVLRYS 384
            ..|.......:..||..:...|.:...::.|:|.|..: :|...:.|...||||.|.|.||.|:.
  Rat   307 TAGMVTTATTLTWALLLMILYPDVQRRVQQEIDEVIGQ-VRCPEMTDQAHMPYTNAVIHEVQRFG 370

  Fly   385 S-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFL--ENNFTNNKE 445
            . :|: :|.:...|..::.|.:.|||.:.||...:...|:.|..|.:|.||.||  :.||..::
  Rat   371 DIAPLNLPRITSCDIEVQDFVIPKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHE- 434

  Fly   446 SGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLVRGFG 510
                                                       .|:|||.|:|.|:|:.|.|...
  Rat   435 -------------------------------------------AFMPFSAGRRACLGEPLARMEL 456

  Fly   511 FLLLANIIQNYN 522
            ||....::|:::
  Rat   457 FLFFTCLLQHFS 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	109/498 (22%)
Cyp2d5	NP_775426.1	p450	37..496	CDD:278495	109/499 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920