DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2d1

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_695225.1	Gene:	Cyp2d1 / 266684	RGDID:	708427	Length:	504	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	118/538 - (21%)
Similarity:	219/538 - (40%)	Gaps:	102/538 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LFAIAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNP 73
            |:::||    .:.:|:||         :.|:::..::.. ...|||.|||::|  |||.....|.
  Rat     9 LWSMAI----FTVIFILL---------VDLMHRRHRWTS-RYPPGPVPWPVLG--NLLQVDLSNM 57

  Fly    74 FYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSL 138
            .|....|..:|||::||..|....::||.:..::|||..:|:....||....:..|....|:..:
  Rat    58 PYSLYKLQHRYGDVFSLQKGWKPMVIVNRLKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQGV 122

  Fly   139 ALCDWS-QLQQKRR----NLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDVKP 198
            .|..:. :.:::||    .|.......:....:.:|       |...|.|..| ..:|...:.|.
  Rat   123 ILASYGPEWREQRRFSVSTLRTFGMGKKSLEEWVTK-------EAGHLCDAFT-AQAGQSINPKA 179

  Fly   199 LILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCNHISRIVH 263
            ::..|..|:....:.:.||.|.|....::::..:|...|:: |:        :|...|....::.
  Rat   180 MLNKALCNVIASLIFARRFEYEDPYLIRMVKLVEESLTEVS-GF--------IPEVLNTFPALLR 235

  Fly   264 WSASIRKF---------ILERIVNHRESNININEPDKDFTDALLKSLKEDKN------VSRNTII 313
            ......|.         :|:.::....:..:..:|.::.|||.|..:::.|.      ...|..:
  Rat   236 IPGLADKVFQGQKTFMALLDNLLAENRTTWDPAQPPRNLTDAFLAEVEKAKGNPESSFNDENLRM 300

  Fly   314 FMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASIS 378
            .:::.|..|.......:..||..:...|.:...::.|:|.|..: :|...:.|...||||.|.|.
  Rat   301 VVVDLFTAGMVTTATTLTWALLLMILYPDVQRRVQQEIDEVIGQ-VRCPEMTDQAHMPYTNAVIH 364

  Fly   379 EVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFL--ENN 439
            ||.|:.. :|: :|.:...|..::.|.:.|||.:.||...:...|:.|..|.:|.||.||  :.|
  Rat   365 EVQRFGDIAPLNLPRITSCDIEVQDFVIPKGTTLIINLSSVLKDETVWEKPHRFHPEHFLDAQGN 429

  Fly   440 FTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQS 504
            |..::                                            .|:|||.|:|.|:|:.
  Rat   430 FVKHE--------------------------------------------AFMPFSAGRRACLGEP 450

  Fly   505 LVRGFGFLLLANIIQNYN 522
            |.|...||....::|.::
  Rat   451 LARMELFLFFTCLLQRFS 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	111/495 (22%)
Cyp2d1	NP_695225.1	p450	37..496	CDD:278495	111/496 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920