Protein Alignment spok and Cyp2d1

DIOPT Version :10

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_695225.1
• Gene: Cyp2d1 / 266684
• RGDID: 708427
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 538
• Identity: 118/538 - (21%)
• Similarity: 219/538 - (40%)
• Gaps: 102/538 - (18%)

  Fly     9 LFAIAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNP 73
            |:::||    .:.:|:||         :.|:::..::.. ...|||.|||::|  |||.....|.
  Rat     9 LWSMAI----FTVIFILL---------VDLMHRRHRWTS-RYPPGPVPWPVLG--NLLQVDLSNM 57

  Fly    74 FYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSL 138
            .|....|..:|||::||..|....::||.:..::|||..:|:....||....:..|....|:..:
  Rat    58 PYSLYKLQHRYGDVFSLQKGWKPMVIVNRLKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQGV 122

  Fly   139 ALCDWS-QLQQKRR----NLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDVKP 198
            .|..:. :.:::||    .|.......:....:.:|       |...|.|..| ..:|...:.|.
  Rat   123 ILASYGPEWREQRRFSVSTLRTFGMGKKSLEEWVTK-------EAGHLCDAFT-AQAGQSINPKA 179

  Fly   199 LILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCNHISRIVH 263
            ::..|..|:....:.:.||.|.|....::::..:|...|:: |:        :|...|....::.
  Rat   180 MLNKALCNVIASLIFARRFEYEDPYLIRMVKLVEESLTEVS-GF--------IPEVLNTFPALLR 235

  Fly   264 WSASIRKF---------ILERIVNHRESNININEPDKDFTDALLKSLKEDKN------VSRNTII 313
            ......|.         :|:.::....:..:..:|.::.|||.|..:::.|.      ...|..:
  Rat   236 IPGLADKVFQGQKTFMALLDNLLAENRTTWDPAQPPRNLTDAFLAEVEKAKGNPESSFNDENLRM 300

  Fly   314 FMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASIS 378
            .:::.|..|.......:..||..:...|.:...::.|:|.|..: :|...:.|...||||.|.|.
  Rat   301 VVVDLFTAGMVTTATTLTWALLLMILYPDVQRRVQQEIDEVIGQ-VRCPEMTDQAHMPYTNAVIH 364

  Fly   379 EVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFL--ENN 439
            ||.|:.. :|: :|.:...|..::.|.:.|||.:.||...:...|:.|..|.:|.||.||  :.|
  Rat   365 EVQRFGDIAPLNLPRITSCDIEVQDFVIPKGTTLIINLSSVLKDETVWEKPHRFHPEHFLDAQGN 429

  Fly   440 FTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQS 504
            |..::                                            .|:|||.|:|.|:|:.
  Rat   430 FVKHE--------------------------------------------AFMPFSAGRRACLGEP 450

  Fly   505 LVRGFGFLLLANIIQNYN 522
            |.|...||....::|.::
  Rat   451 LARMELFLFFTCLLQRFS 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	CYP1_2-like	85..547	CDD:410710	97/462 (21%)
Cyp2d1	NP_695225.1	CYP2D	68..495	CDD:410756	98/463 (21%)