DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	125/541 - (23%)
Similarity:	208/541 - (38%)	Gaps:	123/541 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PGPHPWPIIGNINLLGRFQYNPFYGFG------TLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVL 110
            |||.|.|:.|.|       :|  ||.|      ...||||.|:....|....:.:.:.::||.||
  Rat    39 PGPKPVPLFGTI-------FN--YGDGMWKFDDDCYKKYGKIWGFYEGPQPFLAIMDPEIIKMVL 94

  Fly   111 NKNGKYFGGRPDFFRYHKLFG--GDRNNSLALC---DWSQLQQKRRNLARRHCSPRESSSYFSKM 170
            .|...      ..|...:.||  |....::.:.   :|.:|        |...||..:|....:|
  Rat    95 VKECY------SVFTNRRCFGPMGFMKKAITMSEDEEWKRL--------RTILSPTFTSGKLKEM 145

  Fly   171 SEIGGLEVNQLLDQL-TNISSGYPCDVKPLILAASANMFCQYMCSVRF----NYSDKGFQ---KI 227
            ..:.....:.||..| ...:.|.|.::|.:..|.|.::.......|..    |..|...|   ||
  Rat   146 FPLMRQYGDTLLKNLRREEAKGEPINMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKI 210

  Fly   228 IEY--FDEIFWEINQGYSFDYIPWLVPFYCNHISRIVHWSASIRK---FILERIVNHRESNININ 287
            :::  ||...      .|....|:|.|.|     .::::|...|:   |..:.:...:::.::.|
  Rat   211 LKFQIFDPFL------LSVVLFPFLTPIY-----EMLNFSIFPRQSMNFFKKFVKTMKKNRLDSN 264

  Fly   288 EPDK-DFTDALL-----------KSLKEDKNVSRNTIIFMLEDFIGGHSAVGNLVMLALAYIAKN 340
            :..: ||...::           |:| .|..::...|||:    .||:.|....:...:..:|..
  Rat   265 QKSRVDFLQLMMNTQNSKGQESQKAL-SDLEMAAQAIIFI----FGGYDATSTSISFIMYELATR 324

  Fly   341 PTIALHIRNEVDTVSAKGIRRICLYD-MNVMPYTMASISEVLR-YSSSPIVPHVAMEDTVIKGFG 403
            |.:...::||:|  .|...:....|| :..|.|....::|.|| |..:..:..|:.:|..|.|..
  Rat   325 PNVQKKLQNEID--RALPNKAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVF 387

  Fly   404 VRKGTIVFINNYVLNMSESFWNHPEQFDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGST 468
            :.|||:|.|..|.|:.:..:|..||:|:||||                         ..:|.||.
  Rat   388 IPKGTVVTIPIYPLHRNPEYWLEPEEFNPERF-------------------------SKENKGSI 427

  Fly   469 KSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLVRGFGFLLLANIIQNYNVNSADFSKI-- 531
            ....|                 |||..|.|.|||.........|.:..::||:|:...:.::|
  Rat   428 DPYVY-----------------LPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPL 475

  Fly   532 KLEKSSIALPKKCFKLSLRPR 552
            |:.:..|..|:....|.|..|
  Rat   476 KISRQPIFQPEGPIILKLVSR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	123/536 (23%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	110/498 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000