DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spok and Cyp2e1

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_113731.2	Gene:	Cyp2e1 / 25086	RGDID:	2475	Length:	493	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	156/583 - (26%)
Similarity:	254/583 - (43%)	Gaps:	134/583 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYN---- 72
            :.|||.|:.:|..||        ||.:..|  .|..::..|||.|.||:|||     ||.:
  Rat     4 LGITIALLVWVATLL--------VISIWKQ--IYNSWNLPPGPFPLPILGNI-----FQLDLKDI 53

  Fly    73 PFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDF--FRYHKLFGGDRN 135
            | ..|..|.|::|.:::|.||..|.:|::....:||||..:...|.||.|.  |:.:|..|...|
  Rat    54 P-KSFTKLAKRFGPVFTLHLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFN 117

  Fly   136 N----------SLA-LCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNIS 189
            |          ||: |.||...:|......:|                    |...|:::|.. :
  Rat   118 NGPTWKDVRRFSLSILRDWGMGKQGNEARIQR--------------------EAQFLVEELKK-T 161

  Fly   190 SGYPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPF- 253
            .|.|.|...||..|..|:....:.:.||:|:||...:::..|:|.|:.::       .||:..:
  Rat   162 KGQPFDPTFLIGCAPCNVIADILFNKRFDYNDKKCLRLMSLFNENFYLLS-------TPWIQLYN 219

  Fly   254 ----YCNHI----SRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKN---- 306
                |..::    .:|:...:.|:::.||:...|.:| ::|| ..:|.||.||..::::|:
  Rat   220 NFADYLRYLPGSHRKIMKNVSEIKQYTLEKAKEHLQS-LDIN-CARDVTDCLLIEMEKEKHSQEP 282

  Fly   307 --VSRNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRI-CLYDMN 368
              ...|..:.:.:.|..|.......:...|..:.|.|.|...:..|:|.|.  |..|: .:.|..
  Rat   283 MYTMENVSVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI--GPSRVPAVRDRL 345

  Fly   369 VMPYTMASISEVLRYSS--SPIVPHVAMEDTVIKGFGVRKGTIVF--INNYVLNMSESFWNHPEQ 429
            .|||..|.:.|:.|:.:  ...:||.|..|||.:|:.:.|||:|.  :::.:.:..|  :..||:
  Rat   346 DMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFQGYVIPKGTVVIPTLDSLLYDSHE--FPDPEK 408

  Fly   430 FDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFS 494
            |.||.||..|                          |..|...|                |..||
  Rat   409 FKPEHFLNEN--------------------------GKFKYSDY----------------FKAFS 431

  Fly   495 VGKRTCIGQSLVRGFGFLLLANIIQNYNVNS-ADFSKIKLEKSSI---ALPKKCFKLSLRPRT 553
            .|||.|:|:.|.|...||||:.|:|::|:.| .|...|.|...::   ::|.: |||.:.||:
  Rat   432 AGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGSIPPQ-FKLCVIPRS 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	143/537 (27%)
Cyp2e1	NP_113731.2	CYP2C-like	64..487	CDD:410758	126/499 (25%)
Cyp2e1	NP_113731.2	Substrate binding. /evidence=ECO:0000250	298..303		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920