DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spok and Cyp2c12

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_113760.2	Gene:	Cyp2c12 / 25011	RGDID:	2470	Length:	490	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	154/563 - (27%)
Similarity:	236/563 - (41%)	Gaps:	118/563 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YVLFAIAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGN---INLLGR 68
            :|:..::::.:|:.|::.....:.|.                  .|||.|.||.||   |::...
  Rat     4 FVVLVLSLSFLLLLYLWRPSPGRGKL------------------PPGPTPLPIFGNFLQIDMKDI 50

  Fly    69 FQYNPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGR---PDFFRYHKLF 130
            .|     .....:|.||.:::|..|....:|::..:.:||.|...|:.|.||   |.|.:..|..
  Rat    51 RQ-----SISNFSKTYGPVFTLYFGSQPTVVLHGYEAVKEALIDYGEEFSGRGRMPVFEKATKGL 110

  Fly   131 GGDRNNSLALCDWSQLQQKRRNL--ARRH--CSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSG 191
            |              :...|.|:  |.||  .:...|.....:..||...|..:.|......:.|
  Rat   111 G--------------ISFSRGNVWRATRHFTVNTLRSLGMGKRTIEIKVQEEAEWLVMELKKTKG 161

  Fly   192 YPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQG--YSFDYIPWLVPFY 254
            .|||.|.:|..|..|:.|..:...||:|.||.|..:||..:|....::..  ..|:..|.|:. |
  Rat   162 SPCDPKFIIGCAPCNVICSIIFQNRFDYKDKDFLSLIENVNEYIKIVSTPAFQVFNAFPILLD-Y 225

  Fly   255 C--NHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTD-ALLKSLKEDKNVSRN-----T 311
            |  ||.:...|: |:|:.::|::|..|.|| ::::.| :||.| .|::..:|:.|...|     .
  Rat   226 CPGNHKTHSKHF-AAIKSYLLKKIKEHEES-LDVSNP-RDFIDYFLIQRCQENGNQQMNYTQEHL 287

  Fly   312 IIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMAS 376
            .|.:...||||.......:..||..:.|.|.|...::.|:..|..:. |..|:.|...||||.|.
  Rat   288 AILVTNLFIGGTETSSLTLRFALLLLMKYPHITDKVQEEIGQVIGRH-RSPCMLDRIHMPYTNAM 351

  Fly   377 ISEVLRYSSSPIVP----HVAMEDTVIKGFGVRKGTIVFIN-NYVLNMSESFWNHPEQFDPERFL 436
            |.||.||..  :.|    |....||..:.:.:.|||.|..: ..||:.|:.|.| ||.|||..||
  Rat   352 IHEVQRYID--LAPNGLLHEVTCDTKFRDYFIPKGTAVLTSLTSVLHDSKEFPN-PEMFDPGHFL 413

  Fly   437 ENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCI 501
            :.|                          |:.|...|                |:|||.|||.|:
  Rat   414 DEN--------------------------GNFKKSDY----------------FMPFSAGKRKCV 436

  Fly   502 GQSLVRGFGFLLLANIIQNYNVNS------ADFSKIKLEKSSI 538
            |:.|.....||.|..|:||:.:.|      .|.:.|:.|.|||
  Rat   437 GEGLASMELFLFLTTILQNFKLKSLSDPKDIDINSIRSEFSSI 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	150/518 (29%)
Cyp2c12	NP_113760.2	CYP2C-like	61..485	CDD:410758	139/483 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010