DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2a2

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_036825.1	Gene:	Cyp2a2 / 24895	RGDID:	2464	Length:	492	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	137/547 - (25%)
Similarity:	240/547 - (43%)	Gaps:	109/547 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IAITIIL--ISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNPF 74
            :.:.:||  :|.:||:...:||        .:|:      ..|||.|.|.|||...|.  ..:.:
  Rat     6 LLLVVILASLSVMFLVSLWQQK--------IRER------LPPGPTPLPFIGNYLQLN--MKDVY 54

  Fly    75 YGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSLA 139
            .....|:::||.::::.||..|.:|:...|.:||.|....:.|.||.:...::.||.|   ...:
  Rat    55 SSITQLSERYGPVFTIHLGPRRIVVLYGYDAVKEALVDQAEEFSGRGELPTFNILFKG---YGFS 116

  Fly   140 LCDWSQLQQKRR---------NLARRHCSP--RESSSYFSKMSEIGGLEVNQLLDQLTNISSGYP 193
            |.:..|.::.||         .:.:|....  .|.:.|..|  .:.|             :.|.|
  Rat   117 LSNVEQAKRIRRFTIATLRDFGVGKRDVQECILEEAGYLIK--TLQG-------------TCGAP 166

  Fly   194 CDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDE--IFWEINQGYSFDYIPWLVPFYCN 256
            .|....:....:|:....:...||:|.||.|..::|..||  ||.....|..:|....::.:...
  Rat   167 IDPSIYLSKTVSNVINSIVFGNRFDYEDKEFLSLLEMIDEMNIFAASATGQLYDMFHSVMKYLPG 231

  Fly   257 HISRIVHWSASIRKFILERI-VNHRESNININEPDKDFTDALLKSLKEDKNVS-----RNTIIFM 315
            ...:|:..:..:..|::|:: .||  |.::.|.| ::|.|:.|..::|:|.|:     .|.::..
  Rat   232 PQQQIIKVTQKLEDFMIEKVRQNH--STLDPNSP-RNFIDSFLIRMQEEKYVNSEFHMNNLVMSS 293

  Fly   316 LEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASISEV 380
            |.....|..:|.:.:......:.|:|.:...:..|::.|..:. |:....|...||||.|.|:|:
  Rat   294 LGLLFAGTGSVSSTLYHGFLLLMKHPDVEAKVHEEIERVIGRN-RQPQYEDHMKMPYTQAVINEI 357

  Fly   381 LRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVF-INNYVLNMSESFWNHPEQFDPERFLENNFTN 442
            .|:|: :|: :|...:::|..:||.:.|||.|| |...::...:.|.|| :.|:|:.||
  Rat   358 QRFSNLAPLGIPRRIIKNTTFRGFFLPKGTDVFPIIGSLMTEPKFFPNH-KDFNPQHFL------ 415

  Fly   443 NKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLVR 507
                                |:.|.               |||: ..|||||:|||.|:|.||.:
  Rat   416 --------------------DDKGQ---------------LKKN-AAFLPFSIGKRFCLGDSLAK 444

  Fly   508 GFGFLLLANIIQNYN----VNSADFSK 530
            ...||||..|:||:.    :|..|.::
  Rat   445 MELFLLLTTILQNFRFKFPMNLEDINE 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	129/505 (26%)
Cyp2a2	NP_036825.1	p450	33..489	CDD:278495	129/506 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920