Protein Alignment spok and Cyp2j12

DIOPT Version :10

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001093652.1
• Gene: Cyp2j12 / 242546
• MGIID: 3717097
• Length: 502
• Species: Mus musculus
• Alignment Length: 554
• Identity: 144/554 - (25%)
• Similarity: 220/554 - (39%)
• Gaps: 125/554 - (22%)

  Fly    15 TIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYN---PFYG 76
            |::|.:..|:||....|.       .:.|.|     .|||...|.:||:     ||.:   |...
Mouse    20 TLVLAAVTFMLLAHYLKT-------QRPKNY-----PPGPWRLPFVGNL-----FQLDLEQPHVV 67

  Fly    77 FGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSLALC 141
            .....||||::.||..|:...:::..:.|||||.....:.|..||......::|   .||.|.:.
Mouse    68 IQQFVKKYGNLTSLDFGNIPSVIITGLPLIKEVFTNMEQNFLNRPITPIRKRVF---NNNGLIIS 129

  Fly   142 DWSQLQQKRR---------NLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDVK 197
            :....:::||         .|.::....|........:..||.             ..|.|.|..
Mouse   130 NGQTWKEQRRFALMTLKNFGLGKKSLEQRIQKEADCLVEAIGE-------------EKGQPFDPH 181

  Fly   198 PLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDE--------------IFWEINQGYSFDYIP 248
            ..|.:|.:|:.|.:....||.|.|..|.:::...||              :|..|.|     |:|
Mouse   182 FKINSAVSNIICTFAFGERFEYEDSHFHELLRLLDEATCLEASMMCQLYNVFPSIIQ-----YVP 241

  Fly   249 WLVPFYCNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKE--DKNVS--- 308
            .      :|.:.:.:|. .::.||.:.:.:||: :.|.:|| :||.||.|..:.:  ||..:
Mouse   242 G------SHQTVLRNWE-KLKLFIYQMMESHRK-DWNPDEP-RDFIDAFLTEMSKYGDKTTTSFN 297

  Fly   309 -RNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPY 372
             .|.|...|:.|..|.....|.:..||.||..||.:...:.:|:|.|...| |:....|.:.|||
Mouse   298 EENLINSTLDLFFAGSETTTNTLRWALLYITTNPEVQEKVHSEIDRVIGHG-RQPSTDDRDSMPY 361

  Fly   373 TMASISEVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERF 435
            |.|.|.||||..: .|: ||.....|:.:.||.:.|||:|..|...|:.....|..|..|:||.|
Mouse   362 TNAVIHEVLRMGNILPMNVPREVTADSTLAGFHLPKGTMVLTNLTALHRDPKEWATPNTFNPEHF 426

  Fly   436 LENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTC 500
            |||.....:||                                           |||||:|||.|
Mouse   427 LENGQFKKRES-------------------------------------------FLPFSLGKRAC 448

  Fly   501 IGQSLVRGFGFLLLANIIQNYNVNSADFSKIKLE 534
            .|:.|.|...|:....::|.:........|:.|:
Mouse   449 PGEQLARSELFIFFTALMQKFTFKPPINEKLSLK 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	CYP1_2-like	85..547	CDD:410710	124/481 (26%)
Cyp2j12	NP_001093652.1	cytochrome_P450	75..496	CDD:477761	125/482 (26%)