DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2a22

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001094937.1	Gene:	Cyp2a22 / 233005	MGIID:	3648316	Length:	492	Species:	Mus musculus

Alignment Length:	535	Identity:	138/535 - (25%)
Similarity:	230/535 - (42%)	Gaps:	104/535 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LFAIAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNP 73
            |..:|| :..:|.:.|:...:||   :.|.|           .|||.|.|.|||...|.|  .:.
Mouse     6 LLLVAI-LAFLSVMVLVSVWQQK---IRGKL-----------PPGPIPLPFIGNYLQLNR--KDV 53

  Fly    74 FYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSL 138
            :.....|.:.||.::::.||..|.:|:...|.:||.|..|.:.|.||.:...::.||.|   ..:
Mouse    54 YSSITQLQEHYGPVFTIHLGPRRVVVLYGYDAVKEALEDNAEEFSGRGEQATFNTLFKG---YGV 115

  Fly   139 ALCDWSQLQQKRR---------NLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPC 194
            ...:..:.:|.||         .|.:|....|        :.|..|..:..|..     :.|.|.
Mouse   116 TFSNGERAKQLRRFSIATLKDFGLGKRGMEER--------IQEEAGCLIKMLQG-----TCGAPI 167

  Fly   195 DVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQ------GYSFDYIPWLVPF 253
            |....:....:|:....:...||||.||.|..:::...    ::||      |..:|....::.:
Mouse   168 DPTMYLSKTVSNVISSIVFGDRFNYEDKEFLSLLQMMS----QMNQFAASPTGQLYDMFHSVMKY 228

  Fly   254 YCNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKNVS-----RNTII 313
            ......:|:..|..:..|:::: |.|..|.::.|.| :.|.|:.|..::::||.:     :|.::
Mouse   229 LPGPQQQIIKDSHKLEDFMIQK-VKHNHSTLDPNSP-RGFIDSFLIHMQKEKNFNSEFHMKNLVM 291

  Fly   314 FMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASIS 378
            ..|..|..|...|.:|:......:.|:|.:...:..|:|.|..:. |:....|...||||.|.|.
Mouse   292 TSLNLFFAGSETVSSLLRYGFLLLMKHPDVEAKVHEEIDRVIGRN-RQPQYEDHMKMPYTQAVIH 355

  Fly   379 EVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFLENNFT 441
            |:.|:|: :|: :|....:||..:||.:.|||.||.....|.:...|::.|:.|:|:.||
Mouse   356 EIQRFSNFAPLGIPRRITKDTSFRGFFLPKGTDVFPIMGSLMIDPKFFSSPKDFNPQHFL----- 415

  Fly   442 NNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLV 506
                                 |:.|.               ||| ||.|||||:|||:|:|.||.
Mouse   416 ---------------------DDKGQ---------------LKK-IPAFLPFSIGKRSCLGYSLG 443

  Fly   507 RGFGFLLLANIIQNY 521
            :...||....|:||:
Mouse   444 KMQLFLFFTTILQNF 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	129/492 (26%)
Cyp2a22	NP_001094937.1	p450	33..489	CDD:278495	129/493 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920