DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2c70

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_663474.2	Gene:	Cyp2c70 / 226105	MGIID:	2385878	Length:	489	Species:	Mus musculus

Alignment Length:	530	Identity:	141/530 - (26%)
Similarity:	222/530 - (41%)	Gaps:	110/530 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PGPHPWPIIGNINLLGRFQYNPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKY 116
            |||.|.||:|||  |.....|.....|.|.||||.::::.||....:|::....:||.|...|..
Mouse    31 PGPTPLPIVGNI--LQVDVKNISKSMGMLAKKYGPVFTVYLGMKPTVVLHGYKAMKEALIDQGDE 93

  Fly   117 FGGRPDFFRYHKLFGGDRNNSLALCDWSQ------------LQQKRRNLARRHCSPRESSSYFSK 169
            |              .|:.:|..|...||            .|.:|.:|...........:...:
Mouse    94 F--------------SDKTDSSLLSRTSQGLGIVFSNGETWKQTRRFSLMVLRSMGMGKKTIEDR 144

  Fly   170 MSEIGGLEVNQLLDQLTNISSGYPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFD-- 232
            :.|    |:..:||.|.. ::|.|||...|:.....|:....:...||:|:|:.||..:|.|.
Mouse   145 IQE----EILYMLDALRK-TNGSPCDPSFLLACVPCNVISTVIFQHRFDYNDQTFQDFMENFHRK 204

  Fly   233 -EIF---W-EINQGYS-FDYIPWLVPFYCNHISRIVHWSASIRKFILERIVNHRESNININEPDK 291
             ||.   | ::...|. ..|:|.:      | :|.:......:|||||.|..|::| ::::.| :
Mouse   205 IEILASPWSQLCSAYPILYYLPGI------H-NRFLKDVTQQKKFILEEINRHQKS-LDLSNP-Q 260

  Fly   292 DFTDALLKSLKEDKN-----VSRNTIIFMLEDFIG-GHSAVGNLVMLALAYIAKNPTIALHIRNE 350
            ||.|..|..::::|:     .:.:.::..:.|..| |.....:.|...|..:.|.|.:...|:.|
Mouse   261 DFIDYFLIKMEKEKHNQKSEFTMDNLVVSIGDLFGAGTETTSSTVKYGLLLLLKYPEVTAKIQEE 325

  Fly   351 VDTVSAKGIRRICLYDMNVMPYTMASISEVLRY-SSSPI-VPHVAMEDTVIKGFGVRKGT-IVFI 412
            :..|..:. ||..:.|.|.||||.|.:.|:.|| ...|| .|....:|...:|:.:.||| ::..
Mouse   326 IAHVIGRH-RRPTMQDRNHMPYTDAVLHEIQRYIDFVPIPSPRKTTQDVEFRGYHIPKGTSVMAC 389

  Fly   413 NNYVLNMSESFWNHPEQFDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQN 477
            ...|||..:.|.| ||:|||..||                          |..|:.|...|
Mouse   390 LTSVLNDDKEFPN-PEKFDPGHFL--------------------------DEKGNFKKSDY---- 423

  Fly   478 LNNKLLKKSIPQFLPFSVGKRTCIGQSLVRGFGFLLLANIIQNYN----VNSADFSKIKLEKSSI 538
                        |:.||.|:|.|||:.|.|...||:|.||:|::.    |...|.....::...:
Mouse   424 ------------FVAFSAGRRACIGEGLARMEMFLILTNILQHFTLKPLVKPEDIDTKPVQTGLL 476

  Fly   539 ALP---KKCF 545
            .:|   :.||
Mouse   477 HVPPPFELCF 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	141/530 (27%)
Cyp2c70	NP_663474.2	p450	30..486	CDD:278495	139/528 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920