DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2ab1

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_017172441.1	Gene:	Cyp2ab1 / 224044	MGIID:	3644957	Length:	459	Species:	Mus musculus

Alignment Length:	478	Identity:	120/478 - (25%)
Similarity:	190/478 - (39%)	Gaps:	115/478 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRP--DFFRYHKLFGGDR---NNSLA 139
            |.:.:|.::::.||.|..:|::....:||.|..|.:.|.|||  .|||  .|||...   :|.|.
Mouse    19 LAQTHGSVFTVWLGSTPIVVLSGFRAVKEALVSNSEQFSGRPLTPFFR--DLFGEKGVICSNGLT 81

  Fly   140 LCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIG----GLEVNQLLDQLTNIS------SGYPC 194
               |.|        .||.|        .:.:.|:|    .||| ||..:...::      .|...
Mouse    82 ---WRQ--------QRRFC--------LTTLRELGLGKQALEV-QLQHEAAELAKVFLQEEGRAF 126

  Fly   195 DVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSF---------DYIPWL 250
            |.:..|:.::..:....:....|...:..|.::|:       .||.|.:|         |..||.
Mouse   127 DPQIPIIRSTTRVIGTLVFGHHFLSEEPIFLELIQ-------AINLGLAFASTIWRRLYDMFPWA 184

  Fly   251 VPFYCNHIS----RIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKE--DKNVS- 308
            :    .|:|    :|..:..::|.||...|:.|:   :...|..|||.:..|..:.:  |..||
Mouse   185 L----RHLSGPHQKIFQYHEAVRGFIRHEIIRHK---LRTAEAPKDFINCYLSQITKAIDDPVST 242

  Fly   309 ---RNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVM 370
               .|.|..:::.|:||.......:..||.|:..:..|...::.|:|.:.. ..:.||..|...:
Mouse   243 FSEENLIQVVIDLFLGGTDTTATTLHWALIYLVHHRAIQERVQQELDEMLG-AAQTICYEDRERL 306

  Fly   371 PYTMASISEVLRYSSSPIVPHV--AMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPE 433
            |||.|.:.||.|.||...|..|  .:..|.:.|:.|.||||:..|...:......|..|.||:|.
Mouse   307 PYTRAVLHEVQRLSSVVAVGAVRQCVTSTWMHGYYVPKGTIILPNLASVLYDPECWESPHQFNPG 371

  Fly   434 RFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKR 498
            .||                          |.||:..:.:                .|||||.|.|
Mouse   372 HFL--------------------------DKDGNFVANE----------------AFLPFSAGHR 394

  Fly   499 TCIGQSLVRGFGFLLLANIIQNY 521
            .|.|:.|.|...||:.|.:::.:
Mouse   395 VCPGEQLARMELFLMFATLLRTF 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	120/478 (25%)
Cyp2ab1	XP_017172441.1	p450	18..446	CDD:365848	120/478 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010