Protein Alignment spok and Cyp2t1

DIOPT Version :10

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_599196.2
• Gene: Cyp2t1 / 171380
• RGDID: 620086
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 556
• Identity: 132/556 - (23%)
• Similarity: 224/556 - (40%)
• Gaps: 124/556 - (22%)

  Fly     1 MLTSVFYVLFAIAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNI-- 63
            |:|....:|..:.:|::|:|:.:              |.:|.:.....|..|||.|.|::||:
  Rat     1 MVTCEATLLLLLILTLMLMSWGW--------------LAHQARARMQKDLPPGPAPLPLLGNLLQ 51

  Fly    64 ---NLLGRFQYNPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFR 125
               ..|.|....       |:.::|.::::.||....:|::....:::.|......|.||.....
  Rat    52 LQSGHLDRVLME-------LSSRWGPVFTVWLGPRPAVVLSGYAALRDALVLQADAFSGRGSMAV 109

  Fly   126 YHKLFGGDRNNSLALCD---WSQLQQKRRNLARRHCSPRESSSYFSKMSEIG-GL---------E 177
            :.:...|   |.:...:   |..|    ||.|            ...:.|.| |.         |
  Rat   110 FERFTHG---NGIVFSNGPRWRTL----RNFA------------LGALKEFGVGTSTIEERILEE 155

  Fly   178 VNQLLDQLTNISSGYPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIF------W 236
            ...:||:. ..:.|.|.|.:.|:..|.:|:.|..:...|:||.|..|.::::.|.:.|      |
  Rat   156 TACVLDEF-QATMGAPFDPRRLLDNAVSNVICTVVFGKRYNYGDPEFLRLLDLFSDNFRIMSSRW 219

  Fly   237 EINQGYSFDYIPWLVPFYCNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSL 301
                |.:::..|..:.:......||......:|.||.|:|..||:|. ...|| :||.|..|:.:
  Rat   220 ----GETYNMFPSFMDWIPGPHHRIFKNFQELRLFISEQIQWHRQSR-QTGEP-RDFIDCFLEQM 278

  Fly   302 -KE----DKNVSRNTIIFMLED-FIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIR 360
             ||    :.:....|::....: |.||.......:...|..:.|.|.:|..::.|:|....: .|
  Rat   279 DKEHQDPESHFQDETLVMTTHNLFFGGTETTSTTLRYGLLIMLKYPEVAAKVQEELDATVGR-TR 342

  Fly   361 RICLYDMNVMPYTMASISEVLRY-SSSPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESF 423
            ...|.|...:|||.|.:.|:.|: |..|: :|...:.|..::...:.|||      :|:.:..|.
  Rat   343 APSLADRAHLPYTNAVLHEIQRFISVLPLGLPRALIRDVNLRNHFLHKGT------FVIPLLVSA 401

  Fly   424 WNHPEQF-DPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSI 487
            ...|.|| ||:.|...||         .||  :.||   .:||.
  Rat   402 HRDPTQFKDPDHFNPTNF---------LDD--QGEF---QNNDA--------------------- 431

  Fly   488 PQFLPFSVGKRTCIGQSLVRGFGFLLLANIIQNYNV 523
              |:||:.|||.|:|..|.|...||.|..|:|.:::
  Rat   432 --FMPFAPGKRMCLGAGLARSEIFLFLTAILQKFSL 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	CYP1_2-like	85..547	CDD:410710	113/467 (24%)
Cyp2t1	NP_599196.2	cytochrome_P450	68..492	CDD:477761	113/468 (24%)