Protein Alignment spok and CYP21A2

DIOPT Version :10

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_000491.4
• Gene: CYP21A2 / 1589
• HGNCID: 2600
• Length: 495
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 126/513 - (24%)
• Similarity: 210/513 - (40%)
• Gaps: 107/513 - (20%)

  Fly    73 PFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRN-N 136
            |.|..| ||:|:|.||.|.||....:|:|:...|:|.:.|....|.|||:...| ||.  .|| .
Human    46 PIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTY-KLV--SRNYP 106

  Fly   137 SLALCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLT-------NISSGYPC 194
            .|:|.|:|.|.:..:.|.|        |:....:.:    .:..:::|||       ....|.|.
Human   107 DLSLGDYSLLWKAHKKLTR--------SALLLGIRD----SMEPVVEQLTQEFCERMRAQPGTPV 159

  Fly   195 DVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYF---DEIF-----WEINQGYSFDYIPWLV 251
            .::    ...:.:.|..:|.:.|....|....:..|:   .|:.     |.|.   ..|.||:|
Human   160 AIE----EEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQ---IVDVIPFL- 216

  Fly   252 PFYCNHISRIVHWSASIRKFILE-RIVNHRESNININEPDKDFTDALLK-----SLKEDKNVSRN 310
            .|:.|...|.:..:...|..|:| ::..|:||  .:....:|..|.:|:     |::|.......
Human   217 RFFPNPGLRRLKQAIEKRDHIVEMQLRQHKES--LVAGQWRDMMDYMLQGVAQPSMEEGSGQLLE 279

  Fly   311 TIIFM--LEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGI--RRICLYDMNVMP 371
            ..:.|  ::..|||.....|.:..|:.::..:|.|...::.|:|.....|.  .|:...|...:|
Human   280 GHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLP 344

  Fly   372 YTMASISEVLRYSSSPIV----PHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDP 432
            ...|:|:||||.  .|:|    ||.....:.|.|:.:.:||::..|....::.|:.|..|.:|.|
Human   345 LLNATIAEVLRL--RPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWP 407

  Fly   433 ERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGK 497
            :||||.                                   ||.:           :.|.|..|.
Human   408 DRFLEP-----------------------------------GKNS-----------RALAFGCGA 426

  Fly   498 RTCIGQSLVRGFGFLLLANIIQNYN-VNSADF--SKIKLEKSSIALPKKCFKLSLRPR 552
            |.|:|:.|.|...|::|..::|.:. :.|.|.  |...|...|:.|..:.|::.|:||
Human   427 RVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	CYP1_2-like	85..547	CDD:410710	117/494 (24%)
CYP21A2	NP_000491.4	CYP21	56..482	CDD:410767	117/498 (23%)