DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and CYP2J2

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_000766.2	Gene:	CYP2J2 / 1573	HGNCID:	2634	Length:	502	Species:	Homo sapiens

Alignment Length:	548	Identity:	138/548 - (25%)
Similarity:	223/548 - (40%)	Gaps:	113/548 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TIILISYVFLL----LKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLL----GRFQY 71
            |::|.:..|||    ||.:           :.|.|     .|||...|.:||..|:    ...:.
Human    20 TLLLGTVAFLLAADFLKRR-----------RPKNY-----PPGPWRLPFLGNFFLVDFEQSHLEV 68

  Fly    72 NPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNN 136
            ..|      .||||:::||.||....:::..:.||||.|....:.||.||.......:|   :.|
Human    69 QLF------VKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIF---KKN 124

  Fly   137 SLALCDWSQLQQKRR---------NLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGY 192
            .|.:......:::||         .|.::....|..             |..|.|.:.....:|.
Human   125 GLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ-------------EEAQHLTEAIKEENGQ 176

  Fly   193 PCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEI-FWEINQGYS-FDYIPWLVPFYC 255
            |.|....|..|.:|:.|......||.|.|..||::::..||: :.|.::... ::..||::.|..
Human   177 PFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP 241

  Fly   256 N-HISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSL-KEDKNVS-----RNTII 313
            . |.:...:|. .::.|:...|..||: :.|..| .:||.||.||.: |...|.:     .|.|.
Human   242 GPHQTLFSNWK-KLKLFVSHMIDKHRK-DWNPAE-TRDFIDAYLKEMSKHTGNPTSSFHEENLIC 303

  Fly   314 FMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASIS 378
            ..|:.|..|.......:..||.|:|..|.|...::.|:|.|..:| ::........||||.|.|.
Human   304 STLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQG-QQPSTAARESMPYTNAVIH 367

  Fly   379 EVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFLENNFT 441
            ||.|..: .|: ||.....||.:.|:.:.|||::..|...|:...:.|..|:.|:|:.||||...
Human   368 EVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQF 432

  Fly   442 NNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLV 506
            ..:|:                                           |:|||:|||.|:|:.|.
Human   433 KKREA-------------------------------------------FMPFSIGKRACLGEQLA 454

  Fly   507 RGFGFLLLANIIQNYNVNSADFSKIKLE 534
            |...|:...:::|.:.....:..|:.|:
Human   455 RTELFIFFTSLMQKFTFRPPNNEKLSLK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	129/507 (25%)
CYP2J2	NP_000766.2	p450	44..497	CDD:365848	129/508 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920