Protein Alignment spok and CYP2J2

DIOPT Version :10

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_000766.2
• Gene: CYP2J2 / 1573
• HGNCID: 2634
• Length: 502
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 138/548 - (25%)
• Similarity: 223/548 - (40%)
• Gaps: 113/548 - (20%)

  Fly    15 TIILISYVFLL----LKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLL----GRFQY 71
            |::|.:..|||    ||.:           :.|.|     .|||...|.:||..|:    ...:.
Human    20 TLLLGTVAFLLAADFLKRR-----------RPKNY-----PPGPWRLPFLGNFFLVDFEQSHLEV 68

  Fly    72 NPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNN 136
            ..|      .||||:::||.||....:::..:.||||.|....:.||.||.......:|   :.|
Human    69 QLF------VKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIF---KKN 124

  Fly   137 SLALCDWSQLQQKRR---------NLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGY 192
            .|.:......:::||         .|.::....|..             |..|.|.:.....:|.
Human   125 GLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ-------------EEAQHLTEAIKEENGQ 176

  Fly   193 PCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEI-FWEINQGYS-FDYIPWLVPFYC 255
            |.|....|..|.:|:.|......||.|.|..||::::..||: :.|.::... ::..||::.|..
Human   177 PFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP 241

  Fly   256 N-HISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSL-KEDKNVS-----RNTII 313
            . |.:...:|. .::.|:...|..||: :.|..| .:||.||.||.: |...|.:     .|.|.
Human   242 GPHQTLFSNWK-KLKLFVSHMIDKHRK-DWNPAE-TRDFIDAYLKEMSKHTGNPTSSFHEENLIC 303

  Fly   314 FMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASIS 378
            ..|:.|..|.......:..||.|:|..|.|...::.|:|.|..:| ::........||||.|.|.
Human   304 STLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQG-QQPSTAARESMPYTNAVIH 367

  Fly   379 EVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFLENNFT 441
            ||.|..: .|: ||.....||.:.|:.:.|||::..|...|:...:.|..|:.|:|:.||||...
Human   368 EVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQF 432

  Fly   442 NNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLV 506
            ..:|:                                           |:|||:|||.|:|:.|.
Human   433 KKREA-------------------------------------------FMPFSIGKRACLGEQLA 454

  Fly   507 RGFGFLLLANIIQNYNVNSADFSKIKLE 534
            |...|:...:::|.:.....:..|:.|:
Human   455 RTELFIFFTSLMQKFTFRPPNNEKLSLK 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	CYP1_2-like	85..547	CDD:410710	118/470 (25%)
CYP2J2	NP_000766.2	CYP2J	75..496	CDD:410755	119/471 (25%)