DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and CYP2D6

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_000097.3	Gene:	CYP2D6 / 1565	HGNCID:	2625	Length:	497	Species:	Homo sapiens

Alignment Length:	539	Identity:	127/539 - (23%)
Similarity:	220/539 - (40%)	Gaps:	110/539 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNPFYGFG 78
            :.:.:|..:||||         :.|:::.:::.. ...|||.|.|.:||: |...||..| |.|.
Human     7 VPLAVIVAIFLLL---------VDLMHRRQRWAA-RYPPGPLPLPGLGNL-LHVDFQNTP-YCFD 59

  Fly    79 TLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSLALCDW 143
            .|.:::||::||.|..|..:|:|.:..::|.|..:|:....||.......|..|.|:..:.|..:
Human    60 QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARY 124

  Fly   144 SQLQQKRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNIS----------SGYPCDVKP 198
            ....:::|         |.|.|....:    ||....|...:|..:          ||.|.....
Human   125 GPAWREQR---------RFSVSTLRNL----GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNG 176

  Fly   199 LILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCNHISRIVH 263
            |:..|.:|:.....|..||.|.|..|.::::...|...| ..|:..:.:        |.:..::|
Human   177 LLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKE-ESGFLREVL--------NAVPVLLH 232

  Fly   264 WSASIRKFI---------LERIVNHRESNININEPDKDFTDALLKSLKEDKN------VSRNTII 313
            ..|...|.:         |:.::.......:..:|.:|.|:|.|..:::.|.      ...|..|
Human   233 IPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRI 297

  Fly   314 FMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASIS 378
            .:.:.|..|.......:...|..:..:|.:...::.|:|.|..: :||..:.|...||||.|.|.
Human   298 VVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQ-VRRPEMGDQAHMPYTTAVIH 361

  Fly   379 EVLRYSSSPIVP----HVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFLENN 439
            ||.|:..  |||    |:...|..::||.:.|||.:..|...:...|:.|..|.:|.||.||:
Human   362 EVQRFGD--IVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD-- 422

  Fly   440 FTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQ-FLPFSVGKRTCIGQ 503
                          .:..|::                           |: |||||.|:|.|:|:
Human   423 --------------AQGHFVK---------------------------PEAFLPFSAGRRACLGE 446

  Fly   504 SLVRGFGFLLLANIIQNYN 522
            .|.|...||...:::|:::
Human   447 PLARMELFLFFTSLLQHFS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	121/501 (24%)
CYP2D6	NP_000097.3	p450	58..493	CDD:278495	109/476 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920